P4HB ELISA Kit for Human(Homo sapiens) | EIAab.comP4HB ELISA Kit for Human(Homo sapiens)

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Index > Protein center > P4HB(Gene name) > Human

P4HB (Gene name),

Protein disulfide-isomerase (Protein name ), PDIA1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

P4HB(ERBA2L;PDI;PDIA1;PO4DB);

Protein name:

Protein disulfide-isomerase(PDI);

Alternative:

Prolyl 4-hydroxylase subunit beta;Cellular thyroid hormone-binding protein;p55;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Monomers and homotetramers may also occur. Also constitutes the structural subunit of prolyl 4-hydroxylase and of the microsomal triacylglycerol transfer protein MTTP in mammalian cells. Stabilizes both enzymes and retain them in the ER without contributing to the catalytic activity (By similarity). Binds UBQLN1. Binds to CD4, and upon HIV-1 binding to the cell membrane, is part of a P4HB/PDI-CD4-CXCR4-gp120 complex.

Function:

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.

Subcellular Location:

Endoplasmic reticulum lumen Melanosome Cell membrane Peripheral membrane protein Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources (Probable). Localizes near CD4-enriched regions on lymphoid cell surfaces. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Protein Attributes:

Sequence length:

508

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

508:

QKAVKDEL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P07237

KEGG:

hsa:5034

STRING:

9606.ENSP00000327801

UniGene:

Hs.464336

String:

P07237

MIM:

176790

Pfam:

PF00085

Uniprot:

P07237

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ELISA Kit for Human PDI

Cat.:

E1061h

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Packing:

96T

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ELISA Kit for Human PDI

Cat.:

E1061b

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Packing:

96T

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ELISA Kit for Human PDI

Cat.:

E1061r

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MSDS:

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Packing:

96T

ELISA Kit for Human PDI

Cat.:

E1061m

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MSDS:

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Packing:

96T

ELISA Kit for Human PDI

Cat.:

E1061c

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MSDS:

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Packing:

96T

ELISA Kit for Human PDI

MSDS:

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CLIA Kit for Human PDI

Cat.:

U1061r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human PDI

Cat.:

U1061b

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MSDS:

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Packing:

96T

CLIA Kit for Human PDI

Cat.:

U1061m

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MSDS:

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Packing:

96T

CLIA Kit for Human PDI

Cat.:

U1061h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human PDI

MSDS:

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CLIA Kit for Human PDI

Cat.:

U1061c

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human PDI

Cat.:

P1061Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PDI

Cat.:

P1061Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PDI

Cat.:

P1061Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PDI

Monoclonal Antibody for Human PDI

Protein for Human PDI