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Index > Protein center > PIGR(Gene name) > Human
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  • PIGR (Gene name),
  • Polymeric immunoglobulin receptor (Protein name ),  PIGR_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PIGR;
    Protein name:
    Polymeric immunoglobulin receptor(PIgR;Poly-Ig receptor);
    Alternative:
    Hepatocellular carcinoma-associated protein TB6;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
    Subcellular Location:
    Secretory component Secreted
    Protein Attributes:
    Sequence length:
    764
    Sequence:
    50:
    MLLFVLTCLL | AVFPAISTKS | PIFGPEEVNS | VEGNSVSITC | YYPPTSVNRH | 
    100:
    TRKYWCRQGA | RGGCITLISS | EGYVSSKYAG | RANLTNFPEN | GTFVVNIAQL | 
    150:
    SQDDSGRYKC | GLGINSRGLS | FDVSLEVSQG | PGLLNDTKVY | TVDLGRTVTI | 
    200:
    NCPFKTENAQ | KRKSLYKQIG | LYPVLVIDSS | GYVNPNYTGR | IRLDIQGTGQ | 
    250:
    LLFSVVINQL | RLSDAGQYLC | QAGDDSNSNK | KNADLQVLKP | EPELVYEDLR | 
    300:
    GSVTFHCALG | PEVANVAKFL | CRQSSGENCD | VVVNTLGKRA | PAFEGRILLN | 
    350:
    PQDKDGSFSV | VITGLRKEDA | GRYLCGAHSD | GQLQEGSPIQ | AWQLFVNEES | 
    400:
    TIPRSPTVVK | GVAGGSVAVL | CPYNRKESKS | IKYWCLWEGA | QNGRCPLLVD | 
    450:
    SEGWVKAQYE | GRLSLLEEPG | NGTFTVILNQ | LTSRDAGFYW | CLTNGDTLWR | 
    500:
    TTVEIKIIEG | EPNLKVPGNV | TAVLGETLKV | PCHFPCKFSS | YEKYWCKWNN | 
    550:
    TGCQALPSQD | EGPSKAFVNC | DENSRLVSLT | LNLVTRADEG | WYWCGVKQGH | 
    600:
    FYGETAAVYV | AVEERKAAGS | RDVSLAKADA | APDEKVLDSG | FREIENKAIQ | 
    650:
    DPRLFAEEKA | VADTRDQADG | SRASVDSGSS | EEQGGSSRAL | VSTLVPLGLV | 
    700:
    LAVGAVAVGV | ARARHRKNVD | RVSIRSYRTD | ISMSDFENSR | EFGANDNMGA | 
    750:
    SSITQETSLG | GKEEFVATTE | STTETKEPKK | AKRSSKEEAE | MAYKDFLLQS | 
    764:
    STVAAEAQDG | PQEA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    Pfam:
    MIM:
    String:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human PIgR
    Cat.:
    E1286h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human PIgR
    Cat.:
    E1286b
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human PIgR
    Cat.:
    E1286m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human PIgR
    Cat.:
    E1286r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human PIgR
    MSDS:
    Please sign in first.
    ELISA Kit for Human PIgR
    Cat.:
    E1286p
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PIgR
    Cat.:
    U1286r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PIgR
    Cat.:
    U1286b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PIgR
    Cat.:
    U1286m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PIgR
    Cat.:
    U1286p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PIgR
    Cat.:
    U1286h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human PIgR
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human PIgR
    Polyclonal Antibody for Human PIgR
    Polyclonal Antibody for Human PIgR
    Cat.:
    P1286Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PIgR
    Polyclonal Antibody for Human PIgR
    Cat.:
    P1286Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PIgR
    Cat.:
    P1286Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human PIgR
    Monoclonal Antibody for Human PIgR
    Monoclonal Antibody for Human PIgR
    Monoclonal Antibody for Human PIgR
    Monoclonal Antibody for Human PIgR
    Monoclonal Antibody for Human PIgR
    Protein for Human PIgR
    Protein for Human PIgR
    Protein for Human PIgR
    Protein for Human PIgR
    Protein for Human PIgR
    Protein for Human PIgR

    R&D Technical Data
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    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.5

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.1

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    Recovery

    Recovery was determined by spiking various levels of PIgR into serum and plasma .

    Sample Type

    Average(%)

    Recovery  Range (%)

    Serum

    88

    79-99

    Plasma

    95

    90-103

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    Linearity

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of PIgR and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    85-98%

    80-96%

    93-101%

    93-105%

    EDTA plasma(n=5)

    90-101%

    85-94%

    89-96%

    87-99%

    heparin plasma(n=5)

    83-94%

     

    90-102%

    94-103%

    92-101%

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    References
    1. 1.
      "The human transmembrane secretory component (poly-Ig receptor): molecular cloning, restriction fragment length polymorphism and chromosomal sublocalization."
      Krajci P. , Grzeschik K.H. , Geurts van Kessel A.H. , Olaisen B. , Brandtzaeg P.
      Hum. Genet.87:642-648(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-365
    2. 2.
      "Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor)."
      Krajci P. , Kvale D. , Tasken K. , Brandtzaeg P.
      Eur. J. Immunol.22:2309-2315(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT SER-365
    3. 3.
      "Cloning and characterization of hepatocellular carcinoma associated-genes."
      Dong X. , Pang X. , Cheng W.
      Submitted (2002-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT SER-365
      tissue: Small intestine.
    5. 5.
      "Molecular cloning of the human transmembrane secretory component (poly-Ig receptor) and its mRNA expression in human tissues."
      Krajci P. , Solberg R. , Sandberg M. , Oyen O. , Jahnsen T. , Brandtzaeg P.
      Biochem. Biophys. Res. Commun.158:783-789(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 72-764;VARIANT SER-365
    6. 6.
      "The primary structure of human free secretory component and the arrangement of disulfide bonds."
      Eiffert H. , Quentin E. , Decker J. , Hillemeir S. , Hufschmidt M. , Klingmueller D. , Weber M.H. , Hilschmann N.
      Hoppe-Seyler's Z. Physiol. Chem.365:1489-1495(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-577;VARIANT SER-365;DISULFIDE BONDS;GLYCOSYLATION AT ASN-83; ASN-90; ASN-135; ASN-186; ASN-421; ASN-469 AND ASN-499
    7. 7.
      "Determination of the molecular structure of the human free secretory component."
      Eiffert H. , Quentin E. , Wiederhold M. , Hillemeir S. , Decker J. , Weber M. , Hilschmann N.
      Biol. Chem. Hoppe-Seyler372:119-128(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-577;VARIANT SER-365
    8. 8.
      "Human free secretory component is composed of the first 585 amino acid residues of the polymeric immunoglobulin receptor."
      Hughes G.J. , Frutiger S. , Savoy L.-A. , Reason A.J. , Morris H.R. , Jaton J.-C.
      FEBS Lett.410:443-446(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 118-138; 212-230; 232-268; 273-288 AND 578-603
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-83; ASN-90; ASN-421 AND ASN-469
      tissue: Bile.
    10. 10.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-90; ASN-421 AND ASN-469
      tissue: Plasma.
    11. 11.
      "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
      Ramachandran P. , Boontheung P. , Xie Y. , Sondej M. , Wong D.T. , Loo J.A.
      J. Proteome Res.5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-83; ASN-90; ASN-186; ASN-421; ASN-469 AND ASN-499
      tissue: Saliva.
    12. 12.
      "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
      Picariello G. , Ferranti P. , Mamone G. , Roepstorff P. , Addeo F.
      Proteomics8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-83; ASN-90; ASN-135; ASN-186; ASN-421; ASN-469 AND ASN-499
      tissue: Milk.
    13. 13.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-421 AND ASN-469
      tissue: Liver.
    14. 14.
      "A strategy for precise and large scale identification of core fucosylated glycoproteins."
      Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
      Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-469
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "Crystal structure of a polymeric immunoglobulin binding fragment of the human polymeric immunoglobulin receptor."
      Hamburger A.E. , West A.P. Jr. , Bjorkman P.J.
      Structure12:1925-1935(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 19-127
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