Protein name:
Serine/threonine-protein kinase pim-3 ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with BAD. Interacts with PPP2CA; this interaction promotes dephosphorylation of PIM3, ubiquitination and proteasomal degradation. Interacts with SOCS6.
Function:
Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MLLSKFGSLA | HLCGPGGVDH | LPVKILQPAK | ADKESFEKAY | QVGAVLGSGG |
100:
FGTVYAGSRI | ADGLPVAVKH | VVKERVTEWG | SLGGATVPLE | VVLLRKVGAA |
150:
GGARGVIRLL | DWFERPDGFL | LVLERPEPAQ | DLFDFITERG | ALDEPLARRF |
200:
FAQVLAAVRH | CHSCGVVHRD | IKDENLLVDL | RSGELKLIDF | GSGALLKDTV |
250:
YTDFDGTRVY | SPPEWIRYHR | YHGRSATVWS | LGVLLYDMVC | GDIPFEQDEE |
300:
ILRGRLLFRR | RVSPECQQLI | RWCLSLRPSE | RPSLDQIAAH | PWMLGADGGV |
326:
PESCDLRLCT | LDPDDVASTT | SSSESL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Human Serine/threonine-protein kinase pim-3
ELISA Kit for Human Serine/threonine-protein kinase pim-3
ELISA Kit for Human Serine/threonine-protein kinase pim-3
CLIA Kit for Human Serine/threonine-protein kinase pim-3
CLIA Kit for Human Serine/threonine-protein kinase pim-3
CLIA Kit for Human Serine/threonine-protein kinase pim-3
Polyclonal Antibody for Human Serine/threonine-protein kinase pim-3
Polyclonal Antibody for Human Serine/threonine-protein kinase pim-3
Polyclonal Antibody for Human Serine/threonine-protein kinase pim-3
Monoclonal Antibody for Human Serine/threonine-protein kinase pim-3
Monoclonal Antibody for Human Serine/threonine-protein kinase pim-3
Monoclonal Antibody for Human Serine/threonine-protein kinase pim-3
Protein for Human Serine/threonine-protein kinase pim-3
Protein for Human Serine/threonine-protein kinase pim-3
Protein for Human Serine/threonine-protein kinase pim-3
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
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Liver .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Small intestine .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lymph .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION FROM ESTS
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PPP2CA;PHOSPHORYLATION;UBIQUITINATION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF BAD;TISSUE SPECIFICITY
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH BAD;TISSUE SPECIFICITY
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF CDKN1B
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;FUNCTION