Protein name:
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta;PI3K-delta;PI3Kdelta;PtdIns-3-kinase subunit delta) ;
Alternative:
Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta (PtdIns-3-kinase subunit p110-delta;p110delta) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer of a catalytic subunit PIK3CD and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interacts with ERAS.
Function:
Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol-3,4,5-triphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function.
Subcellular Location:
N/A
Protein Attributes:
50:
MPPGVDCPME | FWTKEENQSV | VVDFLLPTGV | YLNFPVSRNA | NLSTIKQLLW |
100:
HRAQYEPLFH | MLSGPEAYVF | TCINQTAEQQ | ELEDEQRRLC | DVQPFLPVLR |
150:
LVAREGDRVK | KLINSQISLL | IGKGLHEFDS | LCDPEVNDFR | AKMCQFCEEA |
200:
AARRQQLGWE | AWLQYSFPLQ | LEPSAQTWGP | GTLRLPNRAL | LVNVKFEGSE |
250:
ESFTFQVSTK | DVPLALMACA | LRKKATVFRQ | PLVEQPEDYT | LQVNGRHEYL |
300:
YGSYPLCQFQ | YICSCLHSGL | TPHLTMVHSS | SILAMRDEQS | NPAPQVQKPR |
350:
AKPPPIPAKK | PSSVSLWSLE | QPFRIELIQG | SKVNADERMK | LVVQAGLFHG |
400:
NEMLCKTVSS | SEVSVCSEPV | WKQRLEFDIN | ICDLPRMARL | CFALYAVIEK |
450:
AKKARSTKKK | SKKADCPIAW | ANLMLFDYKD | QLKTGERCLY | MWPSVPDEKG |
500:
ELLNPTGTVR | SNPNTDSAAA | LLICLPEVAP | HPVYYPALEK | ILELGRHSEC |
550:
VHVTEEEQLQ | LREILERRGS | GELYEHEKDL | VWKLRHEVQE | HFPEALARLL |
600:
LVTKWNKHED | VAQMLYLLCS | WPELPVLSAL | ELLDFSFPDC | HVGSFAIKSL |
650:
RKLTDDELFQ | YLLQLVQVLK | YESYLDCELT | KFLLDRALAN | RKIGHFLFWH |
700:
LRSEMHVPSV | ALRFGLILEA | YCRGSTHHMK | VLMKQGEALS | KLKALNDFVK |
750:
LSSQKTPKPQ | TKELMHLCMR | QEAYLEALSH | LQSPLDPSTL | LAEVCVEQCT |
800:
FMDSKMKPLW | IMYSNEEAGS | GGSVGIIFKN | GDDLRQDMLT | LQMIQLMDVL |
850:
WKQEGLDLRM | TPYGCLPTGD | RTGLIEVVLR | SDTIANIQLN | KSNMAATAAF |
900:
NKDALLNWLK | SKNPGEALDR | AIEEFTLSCA | GYCVATYVLG | IGDRHSDNIM |
950:
IRESGQLFHI | DFGHFLGNFK | TKFGINRERV | PFILTYDFVH | VIQQGKTNNS |
1000:
EKFERFRGYC | ERAYTILRRH | GLLFLHLFAL | MRAAGLPELS | CSKDIQYLKD |
1044:
SLALGKTEEE | ALKHFRVKFN | EALRESWKTK | VNWLAHNVSK | DNRQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human PI3-kinase subunit delta
ELISA Kit for Human PI3-kinase subunit delta
CLIA Kit for Human PI3-kinase subunit delta
CLIA Kit for Human PI3-kinase subunit delta
Polyclonal Antibody for Human PI3-kinase subunit delta
Polyclonal Antibody for Human PI3-kinase subunit delta
Monoclonal Antibody for Human PI3-kinase subunit delta
Monoclonal Antibody for Human PI3-kinase subunit delta
Protein for Human PI3-kinase subunit delta
Protein for Human PI3-kinase subunit delta
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"P110delta, a novel phosphoinositide 3-kinase in leukocytes."
Vanhaesebroeck B.A.M.
,
Welham M.J.
,
Kotani K.
,
Stein R.
,
Warne P.H.
,
Zvelebil M.J.
,
Higashi K.
,
Volinia S.
,
Downward J.
,
Waterfield M.D.
Proc. Natl. Acad. Sci. U.S.A.94:4330-4335(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION TO 675
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;SUBUNIT;INTERACTION WITH HRAS;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue :
Peripheral blood leukocyte .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
6.
"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G.
,
Barlow K.F.
,
McLay K.E.
,
Kaul R.
,
Swarbreck D.
,
Dunham A.
,
Scott C.E.
,
Howe K.L.
,
Woodfine K.
,
Spencer C.C.A.
,
Jones M.C.
,
Gillson C.
,
Searle S.
,
Zhou Y.
,
Kokocinski F.
,
McDonald L.
,
Evans R.
,
Phillips K.
,
Atkinson A.
,
Cooper R.
,
Jones C.
,
Hall R.E.
,
Andrews T.D.
,
Lloyd C.
,
Ainscough R.
,
Almeida J.P.
,
Ambrose K.D.
,
Anderson F.
,
Andrew R.W.
,
Ashwell R.I.S.
,
Aubin K.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Beasley H.
,
Bethel G.
,
Bird C.P.
,
Bray-Allen S.
,
Brown J.Y.
,
Brown A.J.
,
Buckley D.
,
Burton J.
,
Bye J.
,
Carder C.
,
Chapman J.C.
,
Clark S.Y.
,
Clarke G.
,
Clee C.
,
Cobley V.
,
Collier R.E.
,
Corby N.
,
Coville G.J.
,
Davies J.
,
Deadman R.
,
Dunn M.
,
Earthrowl M.
,
Ellington A.G.
,
Errington H.
,
Frankish A.
,
Frankland J.
,
French L.
,
Garner P.
,
Garnett J.
,
Gay L.
,
Ghori M.R.J.
,
Gibson R.
,
Gilby L.M.
,
Gillett W.
,
Glithero R.J.
,
Grafham D.V.
,
Griffiths C.
,
Griffiths-Jones S.
,
Grocock R.
,
Hammond S.
,
Harrison E.S.I.
,
Hart E.
,
Haugen E.
,
Heath P.D.
,
Holmes S.
,
Holt K.
,
Howden P.J.
,
Hunt A.R.
,
Hunt S.E.
,
Hunter G.
,
Isherwood J.
,
James R.
,
Johnson C.
,
Johnson D.
,
Joy A.
,
Kay M.
,
Kershaw J.K.
,
Kibukawa M.
,
Kimberley A.M.
,
King A.
,
Knights A.J.
,
Lad H.
,
Laird G.
,
Lawlor S.
,
Leongamornlert D.A.
,
Lloyd D.M.
,
Loveland J.
,
Lovell J.
,
Lush M.J.
,
Lyne R.
,
Martin S.
,
Mashreghi-Mohammadi M.
,
Matthews L.
,
Matthews N.S.W.
,
McLaren S.
,
Milne S.
,
Mistry S.
,
Moore M.J.F.
,
Nickerson T.
,
O'Dell C.N.
,
Oliver K.
,
Palmeiri A.
,
Palmer S.A.
,
Parker A.
,
Patel D.
,
Pearce A.V.
,
Peck A.I.
,
Pelan S.
,
Phelps K.
,
Phillimore B.J.
,
Plumb R.
,
Rajan J.
,
Raymond C.
,
Rouse G.
,
Saenphimmachak C.
,
Sehra H.K.
,
Sheridan E.
,
Shownkeen R.
,
Sims S.
,
Skuce C.D.
,
Smith M.
,
Steward C.
,
Subramanian S.
,
Sycamore N.
,
Tracey A.
,
Tromans A.
,
Van Helmond Z.
,
Wall M.
,
Wallis J.M.
,
White S.
,
Whitehead S.L.
,
Wilkinson J.E.
,
Willey D.L.
,
Williams H.
,
Wilming L.
,
Wray P.W.
,
Wu Z.
,
Coulson A.
,
Vaudin M.
,
Sulston J.E.
,
Durbin R.M.
,
Hubbard T.
,
Wooster R.
,
Dunham I.
,
Carter N.P.
,
McVean G.
,
Ross M.T.
,
Harrow J.
,
Olson M.V.
,
Beck S.
,
Rogers J.
,
Bentley D.R.
more...
Nature441:315-321(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 1031-1040;PHOSPHORYLATION AT SER-1039;MUTAGENESIS OF ARG-894 AND SER-1039
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-524 AND SER-1039;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.
"PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans."
Soond D.R.
,
Bjorgo E.
,
Moltu K.
,
Dale V.Q.
,
Patton D.T.
,
Torgersen K.M.
,
Galleway F.
,
Twomey B.
,
Clark J.
,
Gaston J.S.H.
,
Tasken K.
,
Bunyard P.
,
Okkenhaug K.
Blood115:2203-2213(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN T-CELLS;ENZYME REGULATION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION
13.
"Phosphoinositide 3-kinase delta gene mutation predisposes to respiratory infection and airway damage."
Angulo I.
,
Vadas O.
,
Garcon F.
,
Banham-Hall E.
,
Plagnol V.
,
Leahy T.R.
,
Baxendale H.
,
Coulter T.
,
Curtis J.
,
Wu C.
,
Blake-Palmer K.
,
Perisic O.
,
Smyth D.
,
Maes M.
,
Fiddler C.
,
Juss J.
,
Cilliers D.
,
Markelj G.
,
Chandra A.
,
Farmer G.
,
Kielkowska A.
,
Clark J.
,
Kracker S.
,
Debre M.
,
Picard C.
,
Pellier I.
,
Jabado N.
,
Morris J.A.
,
Barcenas-Morales G.
,
Fischer A.
,
Stephens L.
,
Hawkins P.
,
Barrett J.C.
,
Abinun M.
,
Clatworthy M.
,
Durandy A.
,
Doffinger R.
,
Chilvers E.R.
,
Cant A.J.
,
Kumararatne D.
,
Okkenhaug K.
,
Williams R.L.
,
Condliffe A.
,
Nejentsev S.
more...
Science342:866-871(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT APDS LYS-1021;CHARACTERIZATION OF VARIANT APDS LYS-1021