PIK3CD ELISA Kit for Human(Homo sapiens) | EIAab.comPIK3CD ELISA Kit for Human(Homo sapiens)

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PIK3CD (Gene name),

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Protein name ), PK3CD_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PIK3CD;

Protein name:

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform(PI3-kinase subunit delta;PI3K-delta;PI3Kdelta;PtdIns-3-kinase subunit delta);

Alternative:

Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(PtdIns-3-kinase subunit p110-delta;p110delta);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of a catalytic subunit PIK3CD and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interacts with ERAS.

Function:

Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol-3,4,5-triphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

1044

Sequence:

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1000:

1044:

SLALGKTEEE | ALKHFRVKFN | EALRESWKTK | VNWLAHNVSK | DNRQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O00329

MIM:

602839

KEGG:

hsa:5293

STRING:

9606.ENSP00000366563

UniGene:

Hs.518451

Pfam:

PF00454

SMR:

O00329

Uniprot:

O00329

FOR

ELISA Kit for Human PI3-kinase subunit delta

Cat.:

E14309h

Price:

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Manual:

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Packing:

96T

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ELISA Kit for Human PI3-kinase subunit delta

Cat.:

E14309m

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human PI3-kinase subunit delta

Cat.:

U14309h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human PI3-kinase subunit delta

Cat.:

U14309m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human PI3-kinase subunit delta

Monoclonal Antibody for Human PI3-kinase subunit delta

Protein for Human PI3-kinase subunit delta

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"P110delta, a novel phosphoinositide 3-kinase in leukocytes."
Vanhaesebroeck B.A.M. , Welham M.J. , Kotani K. , Stein R. , Warne P.H. , Zvelebil M.J. , Higashi K. , Volinia S. , Downward J. , Waterfield M.D.
Proc. Natl. Acad. Sci. U.S.A.94:4330-4335(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

Vanhaesebroeck B.A.M.
Submitted (2003-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 675
3.

"p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes."
Chantry D. , Vojtek A. , Kashishian A. , Holtzman D.A. , Wood C. , Gray P.W. , Cooper J.A. , Hoekstra M.F.
J. Biol. Chem.272:19236-19241(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.

"p37delta is a new isoform of PI3K p110delta that increases cell proliferation and is overexpressed in tumors."
Fransson S. , Uv A. , Eriksson H. , Andersson M.K. , Wettergren Y. , Bergo M. , Ejeskar K.
Oncogene31:3277-3286(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;SUBUNIT;INTERACTION WITH HRAS;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Peripheral blood leukocyte.
5.

"Variations in the human phosphoinositide-3-kinase p110 gene in children with primary B-cell immunodeficiency of unknown etiology."
Jou S.-T. , Chien Y.-H. , Yang Y.-H. , Shyur S.-D. , Chou C.-C. , Chiang B.-L.
Submitted (2005-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
6.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
8.

"Autophosphorylation of p110 delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo."
Vanhaesebroeck B. , Higashi K. , Raven C. , Welham M. , Anderson S. , Brennan P. , Ward S.G. , Waterfield M.D.
EMBO J.18:1292-1302(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1031-1040;PHOSPHORYLATION AT SER-1039;MUTAGENESIS OF ARG-894 AND SER-1039
9.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-524 AND SER-1039;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans."
Soond D.R. , Bjorgo E. , Moltu K. , Dale V.Q. , Patton D.T. , Torgersen K.M. , Galleway F. , Twomey B. , Clark J. , Gaston J.S.H. , Tasken K. , Bunyard P. , Okkenhaug K.
Blood115:2203-2213(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN T-CELLS;ENZYME REGULATION
11.

"PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?"
Rommel C. , Camps M. , Ji H.
Nat. Rev. Immunol.7:191-201(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
12.

"Phosphoinositide 3-kinase delta (PI3Kdelta) in leukocyte signaling and function."
Fung-Leung W.-P.
Cell. Signal.23:603-608(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
13.

"Phosphoinositide 3-kinase delta gene mutation predisposes to respiratory infection and airway damage."
Angulo I. , Vadas O. , Garcon F. , Banham-Hall E. , Plagnol V. , Leahy T.R. , Baxendale H. , Coulter T. , Curtis J. , Wu C. , Blake-Palmer K. , Perisic O. , Smyth D. , Maes M. , Fiddler C. , Juss J. , Cilliers D. , Markelj G. , more...
Science342:866-871(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT APDS LYS-1021;CHARACTERIZATION OF VARIANT APDS LYS-1021

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