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Index > Protein center > PIK3CD(Gene name) > Human
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  • PIK3CD (Gene name),
  • Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Protein name ),  PK3CD_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PIK3CD;
    Protein name:
    Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform(PI3-kinase subunit delta;PI3K-delta;PI3Kdelta;PtdIns-3-kinase subunit delta);
    Alternative:
    Phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(PtdIns-3-kinase subunit p110-delta;p110delta);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of a catalytic subunit PIK3CD and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interacts with ERAS.
    Function:
    Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol-3,4,5-triphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    1044
    Sequence:
    50:
    MPPGVDCPME | FWTKEENQSV | VVDFLLPTGV | YLNFPVSRNA | NLSTIKQLLW | 
    100:
    HRAQYEPLFH | MLSGPEAYVF | TCINQTAEQQ | ELEDEQRRLC | DVQPFLPVLR | 
    150:
    LVAREGDRVK | KLINSQISLL | IGKGLHEFDS | LCDPEVNDFR | AKMCQFCEEA | 
    200:
    AARRQQLGWE | AWLQYSFPLQ | LEPSAQTWGP | GTLRLPNRAL | LVNVKFEGSE | 
    250:
    ESFTFQVSTK | DVPLALMACA | LRKKATVFRQ | PLVEQPEDYT | LQVNGRHEYL | 
    300:
    YGSYPLCQFQ | YICSCLHSGL | TPHLTMVHSS | SILAMRDEQS | NPAPQVQKPR | 
    350:
    AKPPPIPAKK | PSSVSLWSLE | QPFRIELIQG | SKVNADERMK | LVVQAGLFHG | 
    400:
    NEMLCKTVSS | SEVSVCSEPV | WKQRLEFDIN | ICDLPRMARL | CFALYAVIEK | 
    450:
    AKKARSTKKK | SKKADCPIAW | ANLMLFDYKD | QLKTGERCLY | MWPSVPDEKG | 
    500:
    ELLNPTGTVR | SNPNTDSAAA | LLICLPEVAP | HPVYYPALEK | ILELGRHSEC | 
    550:
    VHVTEEEQLQ | LREILERRGS | GELYEHEKDL | VWKLRHEVQE | HFPEALARLL | 
    600:
    LVTKWNKHED | VAQMLYLLCS | WPELPVLSAL | ELLDFSFPDC | HVGSFAIKSL | 
    650:
    RKLTDDELFQ | YLLQLVQVLK | YESYLDCELT | KFLLDRALAN | RKIGHFLFWH | 
    700:
    LRSEMHVPSV | ALRFGLILEA | YCRGSTHHMK | VLMKQGEALS | KLKALNDFVK | 
    750:
    LSSQKTPKPQ | TKELMHLCMR | QEAYLEALSH | LQSPLDPSTL | LAEVCVEQCT | 
    800:
    FMDSKMKPLW | IMYSNEEAGS | GGSVGIIFKN | GDDLRQDMLT | LQMIQLMDVL | 
    850:
    WKQEGLDLRM | TPYGCLPTGD | RTGLIEVVLR | SDTIANIQLN | KSNMAATAAF | 
    900:
    NKDALLNWLK | SKNPGEALDR | AIEEFTLSCA | GYCVATYVLG | IGDRHSDNIM | 
    950:
    IRESGQLFHI | DFGHFLGNFK | TKFGINRERV | PFILTYDFVH | VIQQGKTNNS | 
    1000:
    EKFERFRGYC | ERAYTILRRH | GLLFLHLFAL | MRAAGLPELS | CSKDIQYLKD | 
    1044:
    SLALGKTEEE | ALKHFRVKFN | EALRESWKTK | VNWLAHNVSK | DNRQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    KEGG:
    UniGene:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human PI3-kinase subunit delta
    Cat.:
    E14309h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human PI3-kinase subunit delta
    Cat.:
    E14309m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human PI3-kinase subunit delta
    Cat.:
    U14309h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human PI3-kinase subunit delta
    Cat.:
    U14309m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human PI3-kinase subunit delta
    Polyclonal Antibody for Human PI3-kinase subunit delta
    Monoclonal Antibody for Human PI3-kinase subunit delta
    Monoclonal Antibody for Human PI3-kinase subunit delta
    Protein for Human PI3-kinase subunit delta
    Protein for Human PI3-kinase subunit delta

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      Vanhaesebroeck B.A.M.
      Submitted (2003-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 675
    3. 3.
      "p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes."
      Chantry D. , Vojtek A. , Kashishian A. , Holtzman D.A. , Wood C. , Gray P.W. , Cooper J.A. , Hoekstra M.F.
      J. Biol. Chem.272:19236-19241(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "p37delta is a new isoform of PI3K p110delta that increases cell proliferation and is overexpressed in tumors."
      Fransson S. , Uv A. , Eriksson H. , Andersson M.K. , Wettergren Y. , Bergo M. , Ejeskar K.
      Oncogene31:3277-3286(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;SUBUNIT;INTERACTION WITH HRAS;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Peripheral blood leukocyte.
    5. 5.
      "Variations in the human phosphoinositide-3-kinase p110 gene in children with primary B-cell immunodeficiency of unknown etiology."
      Jou S.-T. , Chien Y.-H. , Yang Y.-H. , Shyur S.-D. , Chou C.-C. , Chiang B.-L.
      Submitted (2005-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    8. 8.
      "Autophosphorylation of p110 delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo."
      Vanhaesebroeck B. , Higashi K. , Raven C. , Welham M. , Anderson S. , Brennan P. , Ward S.G. , Waterfield M.D.
      EMBO J.18:1292-1302(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1031-1040;PHOSPHORYLATION AT SER-1039;MUTAGENESIS OF ARG-894 AND SER-1039
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-524 AND SER-1039;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans."
      Soond D.R. , Bjorgo E. , Moltu K. , Dale V.Q. , Patton D.T. , Torgersen K.M. , Galleway F. , Twomey B. , Clark J. , Gaston J.S.H. , Tasken K. , Bunyard P. , Okkenhaug K.
      Blood115:2203-2213(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN T-CELLS;ENZYME REGULATION
    11. 11.
      "PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?"
      Rommel C. , Camps M. , Ji H.
      Nat. Rev. Immunol.7:191-201(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    12. 12.
      "Phosphoinositide 3-kinase delta (PI3Kdelta) in leukocyte signaling and function."
      Fung-Leung W.-P.
      Cell. Signal.23:603-608(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT APDS LYS-1021;CHARACTERIZATION OF VARIANT APDS LYS-1021
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