PLEKHO1 ELISA Kit for Human(Homo sapiens) | EIAab.comPLEKHO1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PLEKHO1(Gene name) > Human

PLEKHO1 (Gene name),

Pleckstrin homology domain-containing family O member 1 (Protein name ), PKHO1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

PLEKHO1(OC120;HQ0024c;CKIP1;OC120);

Protein name:

Pleckstrin homology domain-containing family O member 1(PH domain-containing family O member 1);

Alternative:

Casein kinase 2-interacting protein 1(CK2-interacting protein 1;CKIP-1);C-Jun-binding protein(JBP);Osteoclast maturation-associated gene 120 protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer or homodimer. Interacts with CK2 and actin capping subunits (capping protein CP-alpha and CP-beta). CKIP1 and CK2 together inhibit the activity of actin capping protein at the barbed ends of actin filaments. Interacts with ATM, IFP35, JUN, JUND, NMI and PI3K. Interacts with AKT1, AKT2 and AKT3 (each isozyme of PKB), PtdIns(3,5)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P2.

Function:

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.

Subcellular Location:

Cell membrane Nucleus Cytoplasm Predominantly localized to the plasma membrane. In C2C12 cells, with the absence of growth factor, it is found in the nucleus. It rapidly translocates to the plasma membrane after insulin stimulation. In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3. However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells.

Protein Attributes:

Sequence length:

409

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

409:

HSQYRKSLM

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.438824

Pfam:

PF00169

STRING:

9606.ENSP00000358120

String:

Q53GL0

SMR:

Q53GL0

KEGG:

hsa:51177

MIM:

608335

Uniprot:

Q53GL0

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ELISA Kit for Human PH domain-containing family O member 1

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ELISA Kit for Human PH domain-containing family O member 1

Cat.:

E15005h

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Packing:

96T

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ELISA Kit for Human PH domain-containing family O member 1

MSDS:

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ELISA Kit for Human PH domain-containing family O member 1

MSDS:

Please sign in first.

ELISA Kit for Human PH domain-containing family O member 1

MSDS:

Please sign in first.