PLCG1 ELISA Kit for Bovine(Bos taurus) | EIAab.comPLCG1 ELISA Kit for Bovine(Bos taurus)

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PLCG1 (Gene name),

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (Protein name ), PLCG1_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PLCG1;

Protein name:

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1;

Alternative:

Phosphoinositide phospholipase C-gamma-1;PLC-148;Phospholipase C-gamma-1(PLC-gamma-1);Phospholipase C-II(PLC-II);

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Interacts (via SH2 domain) with FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated). Interacts (via SH3 domain) with AGAP2. Interacts with LAT (phosphorylated) upon TCR activation. Interacts (via SH3 domain) with the Pro-rich domain of TNK1. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts (via SH3 domain) with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1, THEMIS and CLNK (By similarity). Interacts with RALGPS1 (By similarity). Interacts (via SH3 domain) with HEV ORF3 protein. Interacts (via the SH2 domains) with VIL1 (phosphorylated at C-terminus tyrosine phosphorylation sites). Interacts with AXL and KIT (By similarity). Interacts (via SH2 domain) with RET.

Function:

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as fibroblast growth factor receptors. Plays a role in actin reorganization and cell migration.

Subcellular Location:

Cell projection lamellipodium Cell projection ruffle Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.

Protein Attributes:

Sequence length:

1291

Sequence:

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1250:

1291:

EARYQQPFED | FRISQEHLAD | HFDGRDRRTP | RRTRVNGDNR | L

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Bt.307

SMR:

P08487

String:

P08487

STRING:

9913.ENSBTAP00000023383

Pfam:

PF00168

KEGG:

bta:281987

Uniprot:

P08487

FOR

ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

E0269h

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Packing:

96T

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ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

E0269m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

E0269b

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

E0269r

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MSDS:

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Packing:

96T

CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

U0269b

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MSDS:

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Packing:

96T

CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

U0269h

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

U0269r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

U0269m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

P0269Rb-m

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40ug/0.2ml

Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

P0269Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

P0269Rb-r

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Monoclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Protein for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Sequence similarity of phospholipase C with the non-catalytic region of src."
Stahl M.L. , Ferenz C.R. , Kelleher K.L. , Kriz R.W. , Knopf J.L.
Nature332:269-272(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
2.

"Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro."
Kim J.W. , Sim S.S. , Kim U.H. , Nishibe S. , Whal M.I. , Carpenter G. , Rhee S.G.
J. Biol. Chem.265:3940-3943(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-771; TYR-783 AND TYR-1254
3.

"Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells."
Whal M.I. , Nishibe S. , Kim J.W. , Kim H.K. , Rhee S.G. , Carpenter G.
J. Biol. Chem.265:3944-3948(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-771; TYR-783 AND TYR-1254
4.

"Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors."
Anderson D. , Koch C.A. , Grey L. , Ellis C. , Moran M.F. , Pawson T.
Science250:979-982(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDGFRA
5.

"PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254."
Kim H.K. , Kim J.W. , Zilberstein A. , Margolis B. , Kim J.G. , Schlessinger J. , Rhee S.G.
Cell65:435-441(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-783 AND TYR-1254
6.

"Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7."
Pandey A. , Liu X. , Dixon J.E. , Di Fiore P.P. , Dixit V.M.
J. Biol. Chem.271:10607-10610(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RET
7.

"Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide."
Pascal S.M. , Singer A.U. , Gish G. , Yamazaki T. , Shoelson S.E. , Pawson T. , Kay L.E. , Forman-Kay J.D.
Cell77:461-472(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 663-759

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