Plcg1 ELISA Kit for Mouse(Mus musculus) | EIAab.comPlcg1 ELISA Kit for Mouse(Mus musculus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Plcg1(Gene name) > Mouse

Plcg1 (Gene name),

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 (Protein name ), PLCG1_MOUSE from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Plcg1(Plcg-1);

Protein name:

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1;

Alternative:

Phospholipase C-gamma-1(PLC-gamma-1);Phosphoinositide phospholipase C-gamma-1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts (via SH2 domain) with FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated). Interacts with RALGPS1. Interacts (via SH2 domains) with VIL1 (phosphorylated at C-terminus tyrosine phosphorylation sites). Interacts (via SH2 domain) with RET (By similarity). Interacts with AGAP2 via its SH3 domain. Interacts with LAT (phosphorylated) upon TCR activation. Interacts (via SH3 domain) with the Pro-rich domain of TNK1. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts (via SH3 domain) with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1, THEMIS and CLNK. Interacts with KIT. Interacts with AXL.

Function:

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as fibroblast growth factor receptors. Plays a role in actin reorganization and cell migration.

Subcellular Location:

Cell projection lamellipodium Cell projection ruffle Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.

Protein Attributes:

Sequence length:

1302

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1250:

1300:

1302:

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

KEGG:

mmu:18803

UniGene:

Mm.44463

SMR:

Q62077

Pfam:

PF00168

String:

Q62077

Uniprot:

Q62077

FOR

ELISA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

E0269h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

E0269m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

E0269b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

E0269r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

U0269b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

U0269h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

U0269r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

U0269m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

P0269Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

P0269Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Cat.:

P0269Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Monoclonal Antibody for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

Protein for Mouse 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
2.

"Phospholipase C in mouse oocytes: characterization of beta and gamma isoforms and their possible involvement in sperm-induced Ca2+ spiking."
Dupont G. , McGuinness O.M. , Johnson M.H. , Berridge M.J. , Borgese F.
Biochem. J.316:583-591(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 846-1052
tissue: Oocyte.
3.

"Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase."
Reith A.D. , Ellis C. , Lyman S.D. , Anderson D.M. , Williams D.E. , Bernstein A. , Pawson T.
EMBO J.10:2451-2459(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KIT;PHOSPHORYLATION
4.

"Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction."
Yu J.C. , Heidaran M.A. , Pierce J.H. , Gutkind J.S. , Lombardi D. , Ruggiero M. , Aaronson S.A.
Mol. Cell. Biol.11:3780-3785(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDGFRA;ACTIVATION BY PDGFRA
5.

"Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation."
Bazenet C.E. , Gelderloos J.A. , Kazlauskas A.
Mol. Cell. Biol.16:6926-6936(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDGFRA
6.

"The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma."
Sawano A. , Takahashi T. , Yamaguchi S. , Shibuya M.
Biochem. Biophys. Res. Commun.238:487-491(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;INTERACTION WITH FLT1
7.

"Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains."
Bedford M.T. , Frankel A. , Yaffe M.B. , Clarke S. , Leder P. , Richard S.
J. Biol. Chem.275:16030-16036(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KHDRBS1
8.

"Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b."
Bachmaier K. , Krawczyk C. , Kozieradzki I. , Kong Y.-Y. , Sasaki T. , Oliveira-dos-Santos A. , Mariathasan S. , Bouchard D. , Wakeham A. , Itie A. , Le J. , Ohashi P.S. , Sarosi I. , Nishina H. , Lipkowitz S. , Penninger J.M.
Nature403:211-216(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBLB
9.

"MIST functions through distinct domains in immunoreceptor signaling in the presence and absence of LAT."
Goitsuka R. , Tatsuno A. , Ishiai M. , Kurosaki T. , Kitamura D.
J. Biol. Chem.276:36043-36050(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLNK;DOMAIN
10.

"Mechanism of TrkB-mediated hippocampal long-term potentiation."
Minichiello L. , Calella A.M. , Medina D.L. , Bonhoeffer T. , Klein R. , Korte M.
Neuron36:121-137(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NTRK2
11.

"Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction."
Jeon M.-S. , Atfield A. , Venuprasad K. , Krawczyk C. , Sarao R. , Elly C. , Yang C. , Arya S. , Bachmaier K. , Su L. , Bouchard D. , Jones R. , Gronski M. , Ohashi P. , Wada T. , Bloom D. , Fathman C.G. , Liu Y.-C. , more...
Immunity21:167-177(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;UBIQUITINATION;FUNCTION
12.

"Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis."
Ceridono M. , Belleudi F. , Ceccarelli S. , Torrisi M.R.
Biochem. Biophys. Res. Commun.327:523-532(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGFR2;PHOSPHORYLATION
13.

"Inositol 5'-phosphatase, SHIP1 interacts with phospholipase C-gamma1 and modulates EGF-induced PLC activity."
Song M. , Kim M.J. , Ha S. , Park J.B. , Ryu S.H. , Suh P.-G.
Exp. Mol. Med.37:161-168(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INPP5D
14.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-771;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation."
Reddi A.L. , Ying G. , Duan L. , Chen G. , Dimri M. , Douillard P. , Druker B.J. , Naramura M. , Band V. , Band H.
J. Biol. Chem.282:29336-29347(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDGFRB
16.

"Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration."
Sun Y. , Ling K. , Wagoner M.P. , Anderson R.A.
J. Cell Biol.178:297-308(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIP5K1C
17.

"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-771 AND TYR-775;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Mast cell.
18.

"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-506 AND TYR-977;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
19.

"Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling."
Fu G. , Vallee S. , Rybakin V. , McGuire M.V. , Ampudia J. , Brockmeyer C. , Salek M. , Fallen P.R. , Hoerter J.A.H. , Munshi A. , Huang Y.H. , Hu J. , Fox H.S. , Sauer K. , Acuto O. , Gascoigne N.R.J.
Nat. Immunol.10:848-856(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH THEMIS
20.

"Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling."
Wang D. , Zheng M. , Lei L. , Ji J. , Yao Y. , Qiu Y. , Ma L. , Lou J. , Ouyang C. , Zhang X. , He Y. , Chi J. , Wang L. , Kuang Y. , Wang J. , Cao X. , Lu L.
Nat. Immunol.13:560-568(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB2; LAT AND THEMIS
tissue: Thymocyte.
21.

"Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling."
Arora D. , Stopp S. , Bohmer S.A. , Schons J. , Godfrey R. , Masson K. , Razumovskaya E. , Ronnstrand L. , Tanzer S. , Bauer R. , Bohmer F.D. , Muller J.P.
J. Biol. Chem.286:10918-10929(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION IN RESPONSE TO FLT3 SIGNALING

Product Feedback Wall

* Email:
*Comments: