PNPLA6 ELISA Kit for Human(Homo sapiens) | EIAab.comPNPLA6 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PNPLA6(Gene name) > Human

PNPLA6 (Gene name),

Neuropathy target esterase (Protein name ), PLPL6_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PNPLA6(NTE);

Protein name:

Neuropathy target esterase;

Alternative:

Patatin-like phospholipase domain-containing protein 6;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Function:

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.

Subcellular Location:

Endoplasmic reticulum membrane Single-pass type I membrane protein Cytoplasmic side Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment.

Protein Attributes:

Sequence length:

1366

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

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800:

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950:

1000:

1050:

1100:

1150:

1200:

1250:

1300:

1350:

1366:

QRRCLPQEPP | GSATDA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q8IY17

MIM:

603197

KEGG:

hsa:10908

Pfam:

PF00027

STRING:

9606.ENSP00000221249

UniGene:

Hs.631863

String:

Q8IY17

Uniprot:

Q8IY17

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ELISA Kit for Human Neuropathy target esterase

Cat.:

E2147h

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Manual:

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Packing:

96T

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ELISA Kit for Human Neuropathy target esterase

Cat.:

E2147m

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MSDS:

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Packing:

96T

CLIA Kit for Human Neuropathy target esterase

Cat.:

U2147h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Neuropathy target esterase

Cat.:

U2147m

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Packing:

96T

Polyclonal Antibody for Human Neuropathy target esterase

Cat.:

P2147Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Neuropathy target esterase

Cat.:

P2147Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Neuropathy target esterase

Protein for Human Neuropathy target esterase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man."
Lush M.J. , Li Y. , Read D.J. , Willis A.C. , Glynn P.
Biochem. J.332:1-4(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);GLYCOSYLATION;TISSUE SPECIFICITY
tissue: Fetal brain.
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5);VARIANT PRO-403
tissue: Cerebellum.
3.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-1366 (ISOFORM 3);VARIANTS PRO-403 AND ARG-1024
tissue: Brain.
tissue: Duodenum.
tissue: Testis.
6.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 985-1366 (ISOFORMS 1/2)
tissue: Brain.
7.

"The pathogenesis of organophosphate polyneuropathy."
Lotti M.
Crit. Rev. Toxicol.21:465-487(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Neuropathy target esterase and its yeast homologue degrade phosphatidylcholine to glycerophosphocholine in living cells."
Zaccheo O. , Dinsdale D. , Meacock P.A. , Glynn P.
J. Biol. Chem.279:24024-24033(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;SUBCELLULAR LOCATION
9.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-345;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-345; THR-352 AND SER-353;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-345;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"Neuropathy target esterase gene mutations cause motor neuron disease."
Rainier S. , Bui M. , Mark E. , Thomas D. , Tokarz D. , Ming L. , Delaney C. , Richardson R.J. , Albers J.W. , Matsunami N. , Stevens J. , Coon H. , Leppert M. , Fink J.K.
Am. J. Hum. Genet.82:780-785(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SPG39 HIS-929 AND VAL-1051
14.

"PNPLA6 mutations cause Boucher-Neuhauser and Gordon Holmes syndromes as part of a broad neurodegenerative spectrum."
Synofzik M. , Gonzalez M.A. , Lourenco C.M. , Coutelier M. , Haack T.B. , Rebelo A. , Hannequin D. , Strom T.M. , Prokisch H. , Kernstock C. , Durr A. , Schols L. , Lima-Martinez M.M. , Farooq A. , Schule R. , Stevanin G. , Marques W. Jr. , Zuchner S.
Brain137:69-77(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SPG39 ILE-254 AND GLU-831;VARIANTS BNHS TRP-569; LEU-1036; ILE-1049; SER-1057; MET-1101 AND LEU-1113;VARIANTS GLY-1091 AND GLY-1353

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