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Index > Protein center > PON2(Gene name) > Human
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  • PON2 (Gene name),
  • Serum paraoxonase/arylesterase 2 (Protein name ),  PON2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PON2;
    Protein name:
    Serum paraoxonase/arylesterase 2(PON 2);
    Alternative:
    Serum aryldialkylphosphatase 2;Aromatic esterase 2(A-esterase 2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer.
    Function:
    Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.
    Subcellular Location:
    Membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    354
    Sequence:
    50:
    MGRLVAVGLL | GIALALLGER | LLALRNRLKA | SREVESVDLP | HCHLIKGIEA | 
    100:
    GSEDIDILPN | GLAFFSVGLK | FPGLHSFAPD | KPGGILMMDL | KEEKPRAREL | 
    150:
    RISRGFDLAS | FNPHGISTFI | DNDDTVYLFV | VNHPEFKNTV | EIFKFEEAEN | 
    200:
    SLLHLKTVKH | ELLPSVNDIT | AVGPAHFYAT | NDHYFSDPFL | KYLETYLNLH | 
    250:
    WANVVYYSPN | EVKVVAEGFD | SANGINISPD | DKYIYVADIL | AHEIHVLEKH | 
    300:
    TNMNLTQLKV | LELDTLVDNL | SIDPSSGDIW | VGCHPNGQKL | FVYDPNNPPS | 
    350:
    SEVLRIQNIL | CEKPTVTTVY | ANNGSVLQGS | SVASVYDGKL | LIGTLYHRAL | 
    354:
    YCEL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    KEGG:
    SMR:
    MIM:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human PON 2
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    E10064h
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    96T
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    ELISA Kit for Human PON 2
    Cat.:
    E10064r
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    Packing:
    96T
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    ELISA Kit for Human PON 2
    MSDS:
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    ELISA Kit for Human PON 2
    MSDS:
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    ELISA Kit for Human PON 2
    Cat.:
    E10064m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human PON 2
    MSDS:
    Please sign in first.
    CLIA Kit for Human PON 2
    MSDS:
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    CLIA Kit for Human PON 2
    Cat.:
    U10064r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human PON 2
    MSDS:
    Please sign in first.
    CLIA Kit for Human PON 2
    MSDS:
    Please sign in first.
    CLIA Kit for Human PON 2
    Cat.:
    U10064h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human PON 2
    Cat.:
    U10064m
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human PON 2
    Polyclonal Antibody for Human PON 2
    Polyclonal Antibody for Human PON 2
    Polyclonal Antibody for Human PON 2
    Polyclonal Antibody for Human PON 2
    Polyclonal Antibody for Human PON 2
    Cat.:
    P10064Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human PON 2
    Monoclonal Antibody for Human PON 2
    Monoclonal Antibody for Human PON 2
    Monoclonal Antibody for Human PON 2
    Monoclonal Antibody for Human PON 2
    Monoclonal Antibody for Human PON 2
    Protein for Human PON 2
    Protein for Human PON 2
    Protein for Human PON 2
    Protein for Human PON 2
    Protein for Human PON 2
    Protein for Human PON 2

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    References
    1. 1.
      "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family."
      Primo-Parmo S.L. , Sorenson R.C. , Teiber J. , La Du B.N.
      Genomics33:498-507(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT SER-311
      tissue: Liver.
    2. 2.
      "Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence."
      Mochizuki H. , Scherer S.W. , Xi T. , Nickle D.C. , Majer M. , Huizenga J.J. , Tsui L.-C. , Prochazka M.
      Gene213:149-157(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 50-67;ALTERNATIVE SPLICING;VARIANTS GLY-148 AND SER-311
    3. 3.
      "Paraoxonase mRNA,nirs splice variant1."
      Sameshima E. , Tabata Y. , Hayashi A. , Iida K. , Mitsuyama M. , Kanai S. , Furuya T. , Saito T.
      Submitted (2003-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);VARIANT SER-311
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3);VARIANT SER-311
      tissue: Subthalamic nucleus.
      tissue: Testis.
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2003-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLY-148; LEU-172 AND SER-311
    6. 6.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "Human chromosome 7: DNA sequence and biology."
      Scherer S.W. , Cheung J. , MacDonald J.R. , Osborne L.R. , Nakabayashi K. , Herbrick J.-A. , Carson A.R. , Parker-Katiraee L. , Skaug J. , Khaja R. , Zhang J. , Hudek A.K. , Li M. , Haddad M. , Duggan G.E. , Fernandez B.A. , Kanematsu E. , Gentles S. , more...
      Science300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT SER-311
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Skin.
    9. 9.
      "Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein."
      Ng C.J. , Wadleigh D.J. , Gangopadhyay A. , Hama S. , Grijalva V.R. , Navab M. , Fogelman A.M. , Reddy S.T.
      J. Biol. Chem.276:44444-44449(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    10. 10.
      "Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities."
      Draganov D.I. , Teiber J.F. , Speelman A. , Osawa Y. , Sunahara R. , La Du B.N.
      J. Lipid Res.46:1239-1247(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;SUBUNIT
    11. 11.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-254
      tissue: Liver.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus."
      Hegele R.A. , Connelly P.W. , Scherer S.W. , Hanley A.J.G. , Harris S.B. , Tsui L.-C. , Zinman B.
      J. Clin. Endocrinol. Metab.82:3373-3377(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLY-148
    14. 14.
      "DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are associated with the risk of coronary heart disease."
      Sanghera D.K. , Aston C.E. , Saha N. , Kamboh M.I.
      Am. J. Hum. Genet.62:36-44(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-311
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