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Index > Protein center > PRX(Gene name) > Human
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  • PRX (Gene name),
  • Periaxin (Protein name ),  PRAX_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PRX(KIAA1620);
    Protein name:
    Periaxin;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with SCN10A. Found in a complex with SCN10A.
    Function:
    Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition.
    Subcellular Location:
    Isoform 2 Cytoplasm
    Protein Attributes:
    Sequence length:
    1461
    Sequence:
    50:
    MEARSRSAEE | LRRAELVEII | VETEAQTGVS | GINVAGGGKE | GIFVRELRED | 
    100:
    SPAARSLSLQ | EGDQLLSARV | FFENFKYEDA | LRLLQCAEPY | KVSFCLKRTV | 
    150:
    PTGDLALRPG | TVSGYEIKGP | RAKVAKLNIQ | SLSPVKKKKM | VPGALGVPAD | 
    200:
    LAPVDVEFSF | PKFSRLRRGL | KAEAVKGPVP | AAPARRRLQL | PRLRVREVAE | 
    250:
    EAQAARLAAA | APPPRKAKVE | AEVAAGARFT | APQVELVGPR | LPGAEVGVPQ | 
    300:
    VSAPKAAPSA | EAAGGFALHL | PTLGLGAPAP | PAVEAPAVGI | QVPQVELPAL | 
    350:
    PSLPTLPTLP | CLETREGAVS | VVVPTLDVAA | PTVGVDLALP | GAEVEARGEA | 
    400:
    PEVALKMPRL | SFPRFGARAK | EVAEAKVAKV | SPEARVKGPR | LRMPTFGLSL | 
    450:
    LEPRPAAPEV | VESKLKLPTI | KMPSLGIGVS | GPEVKVPKGP | EVKLPKAPEV | 
    500:
    KLPKVPEAAL | PEVRLPEVEL | PKVSEMKLPK | VPEMAVPEVR | LPEVELPKVS | 
    550:
    EMKLPKVPEM | AVPEVRLPEV | QLLKVSEMKL | PKVPEMAVPE | VRLPEVQLPK | 
    600:
    VSEMKLPEVS | EVAVPEVRLP | EVQLPKVPEM | KVPEMKLPKV | PEMKLPEMKL | 
    650:
    PEVQLPKVPE | MAVPDVHLPE | VQLPKVPEMK | LPEMKLPEVK | LPKVPEMAVP | 
    700:
    DVHLPEVQLP | KVPEMKLPKM | PEMAVPEVRL | PEVQLPKVSE | MKLPKVPEMA | 
    750:
    VPDVHLPEVQ | LPKVCEMKVP | DMKLPEIKLP | KVPEMAVPDV | HLPEVQLPKV | 
    800:
    SEIRLPEMQV | PKVPDVHLPK | APEVKLPRAP | EVQLKATKAE | QAEGMEFGFK | 
    850:
    MPKMTMPKLG | RAESPSRGKP | GEAGAEVSGK | LVTLPCLQPE | VDGEAHVGVP | 
    900:
    SLTLPSVELD | LPGALGLQGQ | VPAAKMGKGE | RVEGPEVAAG | VREVGFRVPS | 
    950:
    VEIVTPQLPA | VEIEEGRLEM | IETKVKPSSK | FSLPKFGLSG | PKVAKAEAEG | 
    1000:
    AGRATKLKVS | KFAISLPKAR | VGAEAEAKGA | GEAGLLPALD | LSIPQLSLDA | 
    1050:
    HLPSGKVEVA | GADLKFKGPR | FALPKFGVRG | RDTEAAELVP | GVAELEGKGW | 
    1100:
    GWDGRVKMPK | LKMPSFGLAR | GKEAEVQGDR | ASPGEKAEST | AVQLKIPEVE | 
    1150:
    LVTLGAQEEG | RAEGAVAVSG | MQLSGLKVST | AGQVVTEGHD | AGLRMPPLGI | 
    1200:
    SLPQVELTGF | GEAGTPGQQA | QSTVPSAEGT | AGYRVQVPQV | TLSLPGAQVA | 
    1250:
    GGELLVGEGV | FKMPTVTVPQ | LELDVGLSRE | AQAGEAATGE | GGLRLKLPTL | 
    1300:
    GARARVGGEG | AEEQPPGAER | TFCLSLPDVE | LSPSGGNHAE | YQVAEGEGEA | 
    1350:
    GHKLKVRLPR | FGLVRAKEGA | EEGEKAKSPK | LRLPRVGFSQ | SEMVTGEGSP | 
    1400:
    SPEEEEEEEE | EGSGEGASGR | RGRVRVRLPR | VGLAAPSKAS | RGQEGDAAPK | 
    1450:
    SPVREKSPKF | RFPRVSLSPK | ARSGSGDQEE | GGLRVRLPSV | GFSETGAPGP | 
    1461:
    ARMEGAQAAA | V
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    SMR:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Periaxin
    Cat.:
    E13230r
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Periaxin
    Cat.:
    E13230m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Periaxin
    Cat.:
    E13230h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Periaxin
    Cat.:
    U13230h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Periaxin
    Cat.:
    U13230m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Periaxin
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human Periaxin
    Polyclonal Antibody for Human Periaxin
    Polyclonal Antibody for Human Periaxin
    Monoclonal Antibody for Human Periaxin
    Monoclonal Antibody for Human Periaxin
    Monoclonal Antibody for Human Periaxin
    Protein for Human Periaxin
    Protein for Human Periaxin
    Protein for Human Periaxin

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANTS THR-406; GLN-495; ALA-882; MET-921; GLU-935; ARG-1083; ARG-1132; LYS-1259; GLU-1359 DEL AND CYS-1411
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Nakayama M. , Hirosawa M. , Ohara O.
      DNA Res.7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANT ALA-882
      tissue: Brain.
    3. 3.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-1132
      tissue: PNS.
    5. 5.
      "A mutation in periaxin is responsible for CMT4F, an autosomal recessive form of Charcot-Marie-Tooth disease."
      Guilbot A. , Williams A. , Ravise N. , Verny C. , Brice A. , Sherman D.L. , Brophy P.J. , LeGuern E. , Delague V. , Bareil C. , Megarbane A. , Claustres M.
      Hum. Mol. Genet.10:415-421(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE;TISSUE SPECIFICITY
    6. 6.
      "Late-onset Charcot-Marie-Tooth disease 4F caused by periaxin gene mutation."
      Tokunaga S. , Hashiguchi A. , Yoshimura A. , Maeda K. , Suzuki T. , Haruki H. , Nakamura T. , Okamoto Y. , Takashima H.
      Neurogenetics13:359-365(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMT4F ASN-651
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