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Index > Protein center > Park2(Gene name) > Mouse
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  • Park2 (Gene name),
  • E3 ubiquitin-protein ligase parkin (Protein name ),  PRKN2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Park2(Prkn);
    Protein name:
    E3 ubiquitin-protein ligase parkin;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Forms an E3 ubiquitin ligase complex with UBE2L3 or UBE2L6. Mediates 'Lys-63'-linked polyubiquitination by associating with UBE2V1. Part of a SCF-like complex, consisting of PARK2, CUL1 and FBXW7. Interacts with SNCAIP. Binds to the C2A and C2B domains of SYT11. Interacts and regulates the turnover of SEPT5. Part of a complex, including STUB1, HSP70 and GPR37. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PARK2 and GPR37, thus facilitating PARK2-mediated GPR37 ubiquitination. HSP70 transiently associates with unfolded GPR37 and inhibits the E3 activity of PARK2, whereas, STUB1 enhances the E3 activity of PARK2 through promotion of dissociation of HSP70 from PARK2-GPR37 complexes. Interacts with PSMD4 and PACRG. Interacts with LRKK2. Interacts with RANBP2. Interacts with SUMO1 but not SUMO2, which promotes nuclear localization and autoubiquitination. Interacts (via first RING-type domain) with AIMP2 (via N-terminus) (By similarity). Interacts with PSMA7 and RNF41 (By similarity). Interacts with PINK1.
    Function:
    Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5, ZNF746 and AIMP2. Mediates monoubiquitination as well as 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates 'Lys-63'-linked polyubiquitination of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria. Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in role in regulation of neuron death. Limits the production of reactive oxygen species (ROS). Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of PARK2. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Regulates cyclin-E during neuronal apoptosis. May represent a tumor suppressor gene.
    Subcellular Location:
    Nucleus Endoplasmic reticulum Cytoplasm cytosol Cell projection dendrite Cell junction synapse postsynaptic cell membrane postsynaptic density Mitochondrion Cell junction synapse Mainly localizes in the cytosol. Expressed in the endoplasmic reticulum, dendrites, some presynaptic terminals and in postsynaptic densities. Relocates to dysfunctional mitochondria that have lost the mitochondial membrane potential; recruitement to mitochondria is PINK1-dependent.
    Protein Attributes:
    Sequence length:
    464
    Sequence:
    50:
    MIVFVRFNSS | YGFPVEVDSD | TSILQLKEVV | AKRQGVPADQ | LRVIFAGKEL | 
    100:
    PNHLTVQNCD | LEQQSIVHIV | QRPRRRSHET | NASGGDEPQS | TSEGSIWESR | 
    150:
    SLTRVDLSSH | TLPVDSVGLA | VILDTDSKRD | SEAARGPVKP | TYNSFFIYCK | 
    200:
    GPCHKVQPGK | LRVQCGTCKQ | ATLTLAQGPS | CWDDVLIPNR | MSGECQSPDC | 
    250:
    PGTRAEFFFK | CGAHPTSDKD | TSVALNLITS | NRRSIPCIAC | TDVRSPVLVF | 
    300:
    QCNHRHVICL | DCFHLYCVTR | LNDRQFVHDA | QLGYSLPCVA | GCPNSLIKEL | 
    350:
    HHFRILGEEQ | YTRYQQYGAE | ECVLQMGGVL | CPRPGCGAGL | LPEQGQRKVT | 
    400:
    CEGGNGLGCG | FVFCRDCKEA | YHEGDCDSLL | EPSGATSQAY | RVDKRAAEQA | 
    450:
    RWEEASKETI | KKTTKPCPRC | NVPIEKNGGC | MHMKCPQPQC | KLEWCWNCGC | 
    464:
    EWNRACMGDH | WFDV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse E3 ubiquitin-protein ligase parkin
    Cat.:
    E2353r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse E3 ubiquitin-protein ligase parkin
    Cat.:
    E2353h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse E3 ubiquitin-protein ligase parkin
    Cat.:
    E2353m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse E3 ubiquitin-protein ligase parkin
    Cat.:
    U2353h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse E3 ubiquitin-protein ligase parkin
    Cat.:
    U2353r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse E3 ubiquitin-protein ligase parkin
    Cat.:
    U2353m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase parkin
    Cat.:
    P2353Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase parkin
    Cat.:
    P2353Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase parkin
    Cat.:
    P2353Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase parkin
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase parkin
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase parkin
    Protein for Mouse E3 ubiquitin-protein ligase parkin
    Protein for Mouse E3 ubiquitin-protein ligase parkin
    Protein for Mouse E3 ubiquitin-protein ligase parkin

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    Precision
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    Linearity
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    References
    1. 1.
      "Molecular cloning, gene expression, and identification of a splicing variant of the mouse parkin gene."
      Kitada T. , Asakawa S. , Minoshima S. , Mizuno Y. , Shimizu N.
      Mamm. Genome11:417-421(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;SUBCELLULAR LOCATION
      tissue: Skeletal muscle.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3);TISSUE SPECIFICITY;SUBCELLULAR LOCATION
      strain: BALB/c.
      tissue: Kidney.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      "Differential expression and tissue distribution of parkin isoforms during mouse development."
      Huynh D.P. , Dy M. , Nguyen D. , Kiehl T.-R. , Pulst S.M.
      Brain Res. Dev. Brain Res.130:173-181(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    5. 5.
      "S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function."
      Chung K.K.K. , Thomas B. , Li X. , Pletnikova O. , Troncoso J.C. , Marsh L. , Dawson V.L. , Dawson T.M.
      Science304:1328-1331(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION;S-NITROSYLATION
    6. 6.
      "Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease."
      da Costa C.A. , Sunyach C. , Giaime E. , West A. , Corti O. , Brice A. , Safe S. , Abou-Sleiman P.M. , Wood N.W. , Takahashi H. , Goldberg M.S. , Shen J. , Checler F.
      Nat. Cell Biol.11:1370-1375(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS;DISRUPTION PHENOTYPE
    7. 7.
      "Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential."
      Kuroda Y. , Sako W. , Goto S. , Sawada T. , Uchida D. , Izumi Y. , Takahashi T. , Kagawa N. , Matsumoto M. , Matsumoto M. , Takahashi R. , Kaji R. , Mitsui T.
      Hum. Mol. Genet.21:991-1003(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CHPF;DISRUPTION PHENOTYPE
    8. 8.
      "NMR structure of ubiquitin-like domain in PARKIN: gene product of familial Parkinson's disease."
      Tashiro M. , Okubo S. , Shimotakahara S. , Hatanaka H. , Yasuda H. , Kainosho M. , Yokoyama S. , Shindo H.
      J. Biomol. NMR25:153-156(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-76
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