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Index > Protein center > PTEN(Gene name) > Human
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  • PTEN (Gene name),
  • Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (Protein name ),  PTEN_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PTEN(MMAC1;TEP1);
    Protein name:
    Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;
    Alternative:
    Phosphatase and tensin homolog;Mutated in multiple advanced cancers 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer. The unphosphorylated form interacts with the second PDZ domain of AIP1 and with DLG1 and MAST2 in vitro. Interacts with MAGI2, MAGI3, MAST1 and MAST3, but neither with MAST4 nor with DLG5. Interaction with MAGI2 increases protein stability. Interacts with NEDD4. Interacts with NDFIP1 and NDFIP2; in the presence of NEDD4 or ITCH, this interaction promotes PTEN ubiquitination. Interacts (via C2 domain) with FRK. Interacts with USP7; the interaction is direct. Interacts with ROCK1.
    Function:
    Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability.
    Subcellular Location:
    Cytoplasm Nucleus Nucleus PML body Monoubiquitinated form is nuclear. Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies.
    Protein Attributes:
    Sequence length:
    403
    Sequence:
    50:
    MTAIIKEIVS | RNKRRYQEDG | FDLDLTYIYP | NIIAMGFPAE | RLEGVYRNNI | 
    100:
    DDVVRFLDSK | HKNHYKIYNL | CAERHYDTAK | FNCRVAQYPF | EDHNPPQLEL | 
    150:
    IKPFCEDLDQ | WLSEDDNHVA | AIHCKAGKGR | TGVMICAYLL | HRGKFLKAQE | 
    200:
    ALDFYGEVRT | RDKKGVTIPS | QRRYVYYYSY | LLKNHLDYRP | VALLFHKMMF | 
    250:
    ETIPMFSGGT | CNPQFVVCQL | KVKIYSSNSG | PTRREDKFMY | FEFPQPLPVC | 
    300:
    GDIKVEFFHK | QNKMLKKDKM | FHFWVNTFFI | PGPEETSEKV | ENGSLCDQEI | 
    350:
    DSICSIERAD | NDKEYLVLTL | TKNDLDKANK | DKANRYFSPN | FKVKLYFTKT | 
    400:
    VEEPSNPEAS | SSTSVTPDVS | DNEPDHYRYS | DTTDSDPENE | PFDEDQHTQI | 
    403:
    TKV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    String:
    SMR:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    Cat.:
    E14875m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    Cat.:
    E14875h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    MSDS:
    Please sign in first.
    CLIA Kit for Human Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    MSDS:
    Please sign in first.
    CLIA Kit for Human Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    Cat.:
    U14875h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    Cat.:
    U14875m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    Polyclonal Antibody for Human Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    Polyclonal Antibody for Human Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    Monoclonal Antibody for Human Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    Monoclonal Antibody for Human Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    Monoclonal Antibody for Human Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    Protein for Human Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    Protein for Human Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    Protein for Human Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

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    Precision
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    Linearity
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    References
    1. 1.
      "TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta."
      Li D.M. , Sun H.
      Cancer Res.57:2124-2129(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;INDUCTION
      tissue: Epithelium.
    2. 2.
      "Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers."
      Steck P.A. , Pershouse M.A. , Jasser S.A. , Lin H. , Yung W.K.A. , Ligon A.H. , Langford L.A. , Baumgard M.L. , Hattier T. , Davis T. , Frye C. , Hu R. , Swedlund B. , Teng D.H.-F. , Tavtigian S.V.
      Nat. Genet.15:356-363(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;VARIANTS GLIOMA SER-15; GLU-36; ARG-42; TRP-57 AND THR-319 DEL
    3. 3.
      "PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer."
      Li J. , Yen C. , Liaw D. , Podsypanina K. , Bose S. , Wang S.I. , Puc J. , Miliaresis C. , Rodgers L. , McCombie R. , Bigner S.H. , Giovanella B.C. , Ittmann M. , Tycko B. , Hibshoosh H. , Wigler M.H. , Parsons R.
      Science275:1943-1947(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS GLIOBLASTOMA ARG-129 AND PROSTATE CANCER LEU-134
    4. 4.
      "The expression profile for the tumour suppressor gene PTEN and associated polymorphic markers."
      Hamilton J.A. , Stewart L.M.D. , Ajayi L. , Gray I.C. , Gray N.E. , Roberts K.G. , Watson G.J. , Kaisary A.V. , Snary D.
      Br. J. Cancer82:1671-1676(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      Wang S. , Li J. , Liaw D. , Bose S. , Podsypanina K. , Parsons R.
      Submitted (1997-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "Genomic sequence of PTEN/MMAC1."
      Jensen K. , de la Bastide M. , Parsons R. , Parnell L.D. , Dedhia N. , Gottesman T. , Gnoj L. , Kaplan N. , Lodhi M. , Johnson A.F. , Shohdy N. , Hasegawa A. , Haberman K. , Huang E.N. , Schutz K. , Calma C. , Granat S. , Wigler M.H. , more...
      Submitted (1998-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      "Homo sapiens phosphatase and tensin homolog mRNA splicing variants."
      Yang C.-W. , Hsu Y.-F.
      Submitted (2011-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
    8. 8.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    9. 9.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Spleen.
    10. 10.
      NIEHS SNPs program
      Submitted (2005-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT LEU-290
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    12. 12.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    13. 13.
      "P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase."
      Myers M.P. , Stolarov J.P. , Eng C. , Li J. , Wang S.I. , Wigler M.H. , Parsons R. , Tonks N.K.
      Proc. Natl. Acad. Sci. U.S.A.94:9052-9057(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;CHARACTERIZATION OF VARIANTS GLIOMA TRP-57; ENDOMETRIAL CANCER TYR-123; GLIOBLASTOMA ARG-129; CWS1 ARG-129; PROSTATE CANCER LEU-134; GLIOBLASTOMA ARG-165; BREAST CANCER PRO-167 AND BZ ARG-170
    14. 14.
      "The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate."
      Maehama T. , Dixon J.E.
      J. Biol. Chem.273:13375-13378(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY
    15. 15.
      "The lipid phosphatase activity of PTEN is critical for its tumor suppressor function."
      Myers M.P. , Pass I. , Batty I.H. , Van der Kaay J. , Stolarov J.P. , Hemmings B.A. , Wigler M.H. , Downes C.P. , Tonks N.K.
      Proc. Natl. Acad. Sci. U.S.A.95:13513-13518(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;MUTAGENESIS OF ARG-130;CHARACTERIZATION OF VARIANTS CWS1 SER-124 AND CWS1 GLU-129
    16. 16.
      "Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN."
      Tamura M. , Gu J. , Matsumoto K. , Aota S. , Parsons R. , Yamada K.M.
      Science280:1614-1617(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ASP-92 AND CYS-124;CHARACTERIZATION OF VARIANT GLU-129
    17. 17.
      "The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region."
      Georgescu M.-M. , Kirsch K.H. , Akagi T. , Shishido T. , Hanafusa H.
      Proc. Natl. Acad. Sci. U.S.A.96:10182-10187(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN;CHARACTERIZATION OF VARIANTS THR-319 DEL; GLN-345 AND ILE-348
    18. 18.
      "Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding."
      Adey N.B. , Huang L. , Ormonde P.A. , Baumgard M.L. , Pero R. , Byreddy D.V. , Tavtigian S.V. , Bartel P.L.
      Cancer Res.60:35-37(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DLG1 AND MAST2;PHOSPHORYLATION AT THR-401
    19. 19.
      "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase."
      Wu Y. , Dowbenko D. , Spencer S. , Laura R. , Lee J. , Gu Q. , Lasky L.A.
      J. Biol. Chem.275:21477-21485(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAGI3
    20. 20.
      "Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2."
      Wu X. , Hepner K. , Castelino-Prabhu S. , Do D. , Kaye M.B. , Yuan X.-J. , Wood J. , Ross C. , Sawyers C.L. , Whang Y.E.
      Proc. Natl. Acad. Sci. U.S.A.97:4233-4238(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AIP1
    21. 21.
      "The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation."
      Torres J. , Pulido R.
      J. Biol. Chem.276:993-998(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-370; SER-380; THR-382; THR-383 AND SER-385
    22. 22.
      "Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex."
      Vazquez F. , Grossman S.R. , Takahashi Y. , Rokas M.V. , Nakamura N. , Sellers W.R.
      J. Biol. Chem.276:48627-48630(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;INTERACTION WITH AIP1
    23. 23.
      "Direct identification of PTEN phosphorylation sites."
      Miller S. , Lou D. , Seldin D. , Lane W. , Neel B.
      FEBS Lett.528:145-153(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-366; SER-370 AND SER-385
    24. 24.
      "LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes."
      Mehenni H. , Lin-Marq N. , Buchet-Poyau K. , Reymond A. , Collart M.A. , Picard D. , Antonarakis S.E.
      Hum. Mol. Genet.14:2209-2219(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STK11;SUBCELLULAR LOCATION;PHOSPHORYLATION BY STK11
    25. 25.
      "Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases."
      Valiente M. , Andres-Pons A. , Gomar B. , Torres J. , Gil A. , Tapparel C. , Antonarakis S.E. , Pulido R.
      J. Biol. Chem.280:28936-28943(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAGI2; MAGI3; MAST1; MAST2 AND MAST3;MUTAGENESIS OF VAL-403;PHOSPHORYLATION
    26. 26.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NEDD4
    27. 27.
      "The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network."
      Song M.S. , Salmena L. , Carracedo A. , Egia A. , Lo-Coco F. , Teruya-Feldstein J. , Pandolfi P.P.
      Nature455:813-817(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH USP7;UBIQUITINATION AT LYS-13 AND LYS-289;DEUBIQUITINATION BY USP7;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-13 AND LYS-289
    28. 28.
      "Rak functions as a tumor suppressor by regulating PTEN protein stability and function."
      Yim E.-K. , Peng G. , Dai H. , Hu R. , Li K. , Lu Y. , Mills G.B. , Meric-Bernstam F. , Hennessy B.T. , Craven R.J. , Lin S.-Y.
      Cancer Cell15:304-314(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FRK;PHOSPHORYLATION AT TYR-336;MUTAGENESIS OF TYR-336
    29. 29.
      "X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization."
      Van Themsche C. , Leblanc V. , Parent S. , Asselin E.
      J. Biol. Chem.284:20462-20466(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY XIAP/BIRC4;SUBCELLULAR LOCATION;INTERACTION WITH XIAP/BIRC4
    30. 30.
      "Regulation of PTEN stability and activity by Plk3."
      Xu D. , Yao Y. , Jiang X. , Lu L. , Dai W.
      J. Biol. Chem.285:39935-39942(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-366 AND SER-370;MUTAGENESIS OF THR-366 AND SER-370
    31. 31.
      "Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2."
      Mund T. , Pelham H.R.
      Proc. Natl. Acad. Sci. U.S.A.107:11429-11434(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NDFIP1 AND NDFIP2
    32. 32.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    33. 33.
      "IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling."
      Stohr N. , Kohn M. , Lederer M. , Glass M. , Reinke C. , Singer R.H. , Huttelmaier S.
      Genes Dev.26:176-189(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL MIGRATION
    34. 34.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    35. 35.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE INITIATION (ISOFORM ALPHA);CTG START CODON;FUNCTION (ISOFORM ALPHA);SUBCELLULAR LOCATION (ISOFORM ALPHA)
    36. 36.
      "PTENalpha, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism."
      Liang H. , He S. , Yang J. , Jia X. , Wang P. , Chen X. , Zhang Z. , Zou X. , McNutt M.A. , Shen W.H. , Yin Y.
      Cell Metab.19:836-848(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE INITIATION (ISOFORM ALPHA);CTG START CODON;SUBCELLULAR LOCATION (ISOFORM ALPHA);MUTAGENESIS OF MET-1
    37. 37.
      "Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association."
      Lee J.-O. , Yang H. , Georgescu M.-M. , Di Cristofano A. , Maehama T. , Shi Y. , Dixon J.E. , Pandolfi P. , Pavletich N.P.
      Cell99:323-334(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 8-353 IN COMPLEX WITH L(+)-TARTRATE;SUBUNIT;DOMAIN;MUTAGENESIS OF ASP-92; HIS-93; LYS-125; LYS-128; THR-167; GLN-171; 263-LYS--ALA-269 AND 327-LYS--ALA-335
    38. 38.
      "The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases."
      Tsou H.C. , Teng D.H.-F. , Ping X.L. , Brancolini V. , Davis T. , Hu R. , Xie X.X. , Gruener A.C. , Schrager C.A. , Christiano A.M. , Eng C. , Steck P. , Ott J. , Tavtigian S.V. , Peacocke M.
      Am. J. Hum. Genet.61:1036-1043(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CWS1 ASN-137 INS
    39. 39.
      "Inherited mutations in PTEN that are associated with breast cancer, Cowden disease, and juvenile polyposis."
      Lynch E.D. , Ostermeyer E.A. , Lee M.K. , Arena J.F. , Ji H. , Dann J. , Swisshelm K. , Suchard D. , MacLeod P.M. , Kvinnsland S. , Gjertsen B.T. , Heimdal K. , Lubs H. , Moeller P. , King M.-C.
      Am. J. Hum. Genet.61:1254-1260(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CWS1 GLU-343 AND LEU-347
    40. 40.
      "Somatic mutations of PTEN in glioblastoma multiforme."
      Wang S.I. , Puc J. , Li J. , Bruce J.N. , Cairns P. , Sidransky D. , Parsons R.
      Cancer Res.57:4183-4186(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLIOBLASTOMA TYR-107; PRO-121; ARG-129; ARG-165 AND GLN-345
    41. 41.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CWS1 ARG-123 AND ARG-124
    42. 42.
      "Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome."
      Liaw D. , Marsh D.J. , Li J. , Dahia P.L.M. , Wang S.I. , Zheng Z. , Bose S. , Call K.M. , Tsou H.C. , Peacocke M. , Eng C. , Parsons R.
      Nat. Genet.16:64-67(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CWS1 GLU-129
    43. 43.
      "Germline mutations in PTEN are present in Bannayan-Zonana syndrome."
      Marsh D.J. , Dahia P.L.M. , Zheng Z. , Liaw D. , Parsons R. , Gorlin R.J. , Eng C.
      Nat. Genet.16:333-334(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BRRS ARG-170
    44. 44.
      "Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias."
      Maxwell G.L. , Risinger J.I. , Gumbs C. , Shaw H. , Bentley R.C. , Barrett J.C. , Berchuck A. , Futreal P.A.
      Cancer Res.58:2500-2503(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ENDOMETRIAL HYPERPLASIA ARG-36; LEU-130; CYS-173; ALA-191 AND ILE-348
    45. 45.
      "Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease."
      Chi S.-G. , Kim H.-J. , Park B.-J. , Min H.-J. , Park J.-H. , Kim Y.-W. , Dong S.-H. , Kim B.-H. , Lee J.-I. , Chang Y.-W. , Chang R. , Kim W.-K. , Yang M.-H.
      Gastroenterology115:1084-1089(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CWS1 GLU-289
    46. 46.
      "The genetic basis of Cowden's syndrome: three novel mutations in PTEN/MMAC1/TEP1."
      Tsou H.C. , Ping X.L. , Xie X.X. , Gruener A.C. , Zhang H. , Nini R. , Swisshelm K. , Sybert V. , Diamond T.M. , Sutphen R. , Peacocke M.
      Hum. Genet.102:467-473(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CWS1 HIS-68 AND PRO-112
    47. 47.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CWS1 AND BRRS
    48. 48.
      "Novel mutation of the PTEN gene in an Italian Cowden's disease kindred."
      Scala S. , Bruni P. , Lo Muzio L. , Mignogna M. , Viglietto G. , Fusco A.
      Int. J. Oncol.13:665-668(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CWS1 TYR-136
    49. 49.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CWS1 PRO-70
    50. 50.
      "PTEN germ-line mutations in juvenile polyposis coli."
      Olschwang S. , Serova-Sinilnikova O.M. , Lenoir G.M. , Thomas G.
      Nat. Genet.18:12-14(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CWS1 ARG-35
    51. 51.
      "Variant manifestation of Cowden disease in Japan: hamartomatous polyposis of the digestive tract with mutation of the PTEN gene."
      Kurose K. , Araki T. , Matsunaka T. , Takada Y. , Emi M.
      Am. J. Hum. Genet.64:308-310(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CWS1 GLN-130
    52. 52.
      "Severe Lhermitte-Duclos disease with unique germline mutation of PTEN."
      Sutphen R. , Diamond T.M. , Minton S.E. , Peacocke M. , Tsou H.C. , Root A.W.
      Am. J. Med. Genet.82:290-293(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CWS1/LDD PRO-112
    53. 53.
      "Novel PTEN mutations in patients with Cowden disease: absence of clear genotype-phenotype correlations."
      Nelen M.R. , Kremer H. , Konings I.B.M. , Schoute F. , van Essen A.J. , Koch R. , Woods C.G. , Fryns J.-P. , Hamel B.C.J. , Hoefsloot L.H. , Peeters E.A.J. , Padberg G.W.
      Eur. J. Hum. Genet.7:267-273(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CWS1 ILE-33 DEL; ARG-123; ARG-124 AND GLU-165
    54. 54.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BRRS ASP-34; HIS-68; TYR-105; VAL-135; ARG-170 AND LEU-246
    55. 55.
      "Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay."
      Han S.-Y. , Kato H. , Kato S. , Suzuki T. , Shibata H. , Ishii S. , Shiiba K. , Matsuno S. , Kanamaru R. , Ishioka C.
      Cancer Res.60:3147-3151(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS ASN-10; CYS-16; GLU-20; SER-27; ARG-61; HIS-68; CWS1 TYR-71; CWS1 TYR-93; BRRS PHE-105; BRRS TYR-107; PRO-112; ARG-112; PRO-121; ARG-124; ARG-129; GLU-129; GLY-130; CWS1 LEU-130; GLN-130; ILE-133; LEU-134; TYR-136; CYS-155; ARG-165; ASN-170; ARG-170; CYS-173; HIS-173; PRO-173; ASN-174; PHE-227; CYS-251; GLU-289; GLY-331; VAL-341; ASN-342; GLU-343; GLN-345; LEU-347; GLY-369 AND ILE-401
    56. 56.
      "Novel germline mutations in the PTEN tumour suppressor gene found in women with multiple cancers."
      De Vivo I. , Gertig D.M. , Nagase S. , Hankinson S.E. , O'Brien R. , Speizer F.E. , Parsons R. , Hunter D.J.
      J. Med. Genet.37:336-341(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MULTIPLE CANCERS LEU-119 AND LEU-158
    57. 57.
      "Identification of PTEN mutations in metastatic melanoma specimens."
      Celebi J.T. , Shendrik I. , Silvers D.N. , Peacocke M.
      J. Med. Genet.37:653-657(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MALIGNANT MELANOMA ASN-19 AND ILE-217
    58. 58.
      "PTEN coordinates G1 arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model."
      Weng L.-P. , Brown J.L. , Eng C.
      Hum. Mol. Genet.10:599-604(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS CWS1 SER-124 AND GLU-129
    59. 59.
      "A novel germline mutation of the PTEN gene in a patient with macrocephaly, ventricular dilatation, and features of VATER association."
      Reardon W. , Zhou X.-P. , Eng C.
      J. Med. Genet.38:820-823(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VATER ASP-61
    60. 60.
      "Rapid mutation scanning of genes associated with familial cancer syndromes using denaturing high-performance liquid chromatography."
      Marsh D.J. , Theodosopoulos G. , Howell V. , Richardson A.-L. , Benn D.E. , Proos A.L. , Eng C. , Robinson B.G.
      Neoplasia3:236-244(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CWS1 GLY-47;VARIANTS BRRS ASP-34; HIS-68; TYR-105; VAL-135 AND ARG-170
    61. 61.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT GLN-234
    62. 62.
      "Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10."
      Poetsch M. , Lorenz G. , Kleist B.
      Cancer Genet. Cytogenet.132:20-24(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HNSCC GLY-121
    63. 63.
      "Germline mutation of the tumour suppressor PTEN in Proteus syndrome."
      Smith J.M. , Kirk E.P.E. , Theodosopoulos G. , Marshall G.M. , Walker J. , Rogers M. , Field M. , Brereton J.J. , Marsh D.J.
      J. Med. Genet.39:937-940(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISCUSSION OF PTEN INVOLVEMENT IN PROTEUS SYNDROME
    64. 64.
      "Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations."
      Butler M.G. , Dasouki M.J. , Zhou X.-P. , Talebizadeh Z. , Brown M. , Takahashi T.N. , Miles J.H. , Wang C.H. , Stratton R. , Pilarski R. , Eng C.
      J. Med. Genet.42:318-321(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MCEPHAS ARG-93; SER-241 AND GLY-252
    65. 65.
      "Recurrent 10q22-q23 deletions: a genomic disorder on 10q associated with cognitive and behavioral abnormalities."
      Balciuniene J. , Feng N. , Iyadurai K. , Hirsch B. , Charnas L. , Bill B.R. , Easterday M.C. , Staaf J. , Oseth L. , Czapansky-Beilman D. , Avramopoulos D. , Thomas G.H. , Borg A. , Valle D. , Schimmenti L.A. , Selleck S.B.
      Am. J. Hum. Genet.80:938-947(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CHROMOSOME 10Q23 DELETION SYNDROME
    66. 66.
      "A germline PTEN mutation with manifestations of prenatal onset and verrucous epidermal nevus."
      Tekin M. , Hismi B.O. , Fitoz S. , Yalcinkaya F. , Ekim M. , Kansu A. , Ertem M. , Deda G. , Tutar E. , Arsan S. , Zhou X.-P. , Pilarski R. , Eng C. , Akar N.
      Am. J. Med. Genet. A140:1472-1475(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-132
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