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Index > Protein center > PTPRQ(Gene name) > Human
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  • PTPRQ (Gene name),
  • Phosphotidylinositol phosphatase PTPRQ (Protein name ),  PTPRQ_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    PTPRQ;
    Protein name:
    Phosphotidylinositol phosphatase PTPRQ;
    Alternative:
    3.1.3.48;Receptor-type tyrosine-protein phosphatase Q(PTP-RQ;R-PTP-Q);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    2332
    Sequence:
    50:
    MKKVPIKPEQ | PEKLRAFNIS | THSFSLHWSL | PSGHVERYQV | DLVPDSGFVT | 
    100:
    IRDLGGGEYQ | VDVSNVVPGT | RYDITISSIS | TTYTSPVTRI | VTTNVTKPGP | 
    150:
    PVFLAGERVG | SAGILLSWNT | PPNPNGRIIS | YIVKYKEVCP | WMQTVYTQVR | 
    200:
    SKPDSLEVLL | TNLNPGTTYE | IKVAAENSAG | IGVFSDPFLF | QTAESAPGKV | 
    250:
    VNLTVEAYNA | SAVKLIWYLP | RQPNGKITSF | KISVKHARSG | IVVKDVSIRV | 
    300:
    EDILTGKLPE | CNENSESFLW | STASPSPTLG | RVTPPSRTTH | SSSTLTQNEI | 
    350:
    SSVWKEPISF | VVTHLRPYTT | YLFEVSAVTT | EAGYIDSTIV | RTPESVPEGP | 
    400:
    PQNCVTGNIT | GKSFSILWDP | PTIVTGKFSY | RVELYGPSGR | ILDNSTKDLK | 
    450:
    FAFTNLTPFT | MYDVYIAAET | SAGTGPKSNI | SVFTPPDVPG | AVFDLQLAEV | 
    500:
    ESTQVRITWK | KPRQPNGIIN | QYRVKVLVPE | TGIILENTLL | TGNNEYINDP | 
    550:
    MAPEIVNIVE | PMVGLYEGSA | EMSSDLHSLA | TFIYNSHPDK | NFPARNRAED | 
    600:
    QTSPVVTTRN | QYITDIAAEQ | LSYVIRRLVP | FTEHMISVSA | FTIMGEGPPT | 
    650:
    VLSVRTRQQV | PSSIKIINYK | NISSSSILLY | WDPPEYPNGK | ITHYTIYAME | 
    700:
    LDTNRAFQIT | TIDNSFLITG | LKKYTKYKMR | VAASTHVGES | SLSEENDIFV | 
    750:
    RTSEDEPESS | PQDVEVIDVT | ADEIRLKWSP | PEKPNGIIIA | YEVLYKNIDT | 
    800:
    LYMKNTSTTD | IILRNLRPHT | LYNISVRSYT | RFGHGNQVSS | LLSVRTSETV | 
    850:
    PDSAPENITY | KNISSGEIEL | SFLPPSSPNG | IIKKYTIYLK | RSNGNEERTI | 
    900:
    NTTSLTQNIK | VLKKYTQYII | EVSASTLKGE | GVRSAPISIL | TEEDAPDSPP | 
    950:
    QDFSVKQLSG | VTVKLSWQPP | LEPNGIILYY | TVYVWNRSSL | KTINVTETSL | 
    1000:
    ELSDLDYNVE | YSAYVTASTR | FGDGKTRSNI | ISFQTPEGAP | SDPPKDVYYA | 
    1050:
    NLSSSSIILF | WTPPSKPNGI | IQYYSVYYRN | TSGTFMQNFT | LHEVTNDFDN | 
    1100:
    MTVSTIIDKL | TIFSYYTFWL | TASTSVGNGN | KSSDIIEVYT | DQDIPEGFVG | 
    1150:
    NLTYESISST | AINVSWVPPA | QPNGLVFYYV | SLILQQTPRH | VRPPLVTYER | 
    1200:
    SIYFDNLEKY | TDYILKITPS | TEKGFSDTYT | AQLYIKTEED | VPETSPIINT | 
    1250:
    FKNLSSTSVL | LSWDPPVKPN | GAIISYDLTL | QGPNENYSFI | TSDNYIILEE | 
    1300:
    LSPFTLYSFF | AAARTRKGLG | PSSILFFYTD | ESVPLAPPQN | LTLINCTSDF | 
    1350:
    VWLKWSPSPL | PGGIVKVYSF | KIHEHETDTI | YYKNISGFKT | EAKLVGLEPV | 
    1400:
    STYSIRVSAF | TKVGNGNQFS | NVVKFTTQES | VPDVVQNMQC | MATSWQSVLV | 
    1450:
    KWDPPKKANG | IITQYMVTVE | RNSTKVSPQD | HMYTFIKLLA | NTSYVFKVRA | 
    1500:
    STSAGEGDES | TCHVSTLPET | VPSVPTNIAF | SDVQSTSATL | TWIRPDTILG | 
    1550:
    YFQNYKITTQ | LRAQKCKEWE | SEECVEYQKI | QYLYEAHLTE | ETVYGLKKFR | 
    1600:
    WYRFQVAAST | NAGYGNASNW | ISTKTLPGPP | DGPPENVHVV | ATSPFSISIS | 
    1650:
    WSEPAVITGP | TCYLIDVKSV | DNDEFNISFI | KSNEENKTIE | IKDLEIFTRY | 
    1700:
    SVVITAFTGN | ISAAYVEGKS | SAEMIVTTLE | SAPKDPPNNM | TFQKIPDEVT | 
    1750:
    KFQLTFLPPS | QPNGNIQVYQ | ALVYREDDPT | AVQIHNLSII | QKTNTFVIAM | 
    1800:
    LEGLKGGHTY | NISVYAVNSA | GAGPKVPMRI | TMDIKAPARP | KTKPTPIYDA | 
    1850:
    TGKLLVTSTT | ITIRMPICYY | SDDHGPIKNV | QVLVTETGAQ | HDGNVTKWYD | 
    1900:
    AYFNKARPYF | TNEGFPNPPC | TEGKTKFSGN | EEIYIIGADN | ACMIPGNEDK | 
    1950:
    ICNGPLKPKK | QYLFKFRATN | IMGQFTDSDY | SDPVKTLGEG | LSERTVEIIL | 
    2000:
    SVTLCILSII | LLGTAIFAFA | RIRQKQKEGG | TYSPQDAEII | DTKLKLDQLI | 
    2050:
    TVADLELKDE | RLTRPISKKS | FLQHVEELCT | NNNLKFQEEF | SELPKFLQDL | 
    2100:
    SSTDADLPWN | RAKNRFPNIK | PYNNNRVKLI | ADASVPGSDY | INASYISGYL | 
    2150:
    CPNEFIATQG | PLPGTVGDFW | RMVWETRAKT | LVMLTQCFEK | GRIRCHQYWP | 
    2200:
    EDNKPVTVFG | DIVITKLMED | VQIDWTIRDL | KIERHGDCMT | VRQCNFTAWP | 
    2250:
    EHGVPENSAP | LIHFVKLVRA | SRAHDTTPMI | VHCSAGVGRT | GVFIALDHLT | 
    2300:
    QHINDHDFVD | IYGLVAELRS | ERMCMVQNLA | QYIFLHQCIL | DLLSNKGSNQ | 
    2332:
    PICFVNYSAL | QKMDSLDAME | GDVELEWEET | TM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    MIM:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Phosphotidylinositol phosphatase PTPRQ
    Cat.:
    E10382m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Phosphotidylinositol phosphatase PTPRQ
    Cat.:
    E10382r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Phosphotidylinositol phosphatase PTPRQ
    Cat.:
    E10382h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Phosphotidylinositol phosphatase PTPRQ
    Cat.:
    U10382m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Phosphotidylinositol phosphatase PTPRQ
    Cat.:
    U10382h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Phosphotidylinositol phosphatase PTPRQ
    Cat.:
    U10382r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Phosphotidylinositol phosphatase PTPRQ
    Cat.:
    P10382Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Phosphotidylinositol phosphatase PTPRQ
    Polyclonal Antibody for Human Phosphotidylinositol phosphatase PTPRQ
    Monoclonal Antibody for Human Phosphotidylinositol phosphatase PTPRQ
    Monoclonal Antibody for Human Phosphotidylinositol phosphatase PTPRQ
    Monoclonal Antibody for Human Phosphotidylinositol phosphatase PTPRQ
    Protein for Human Phosphotidylinositol phosphatase PTPRQ
    Protein for Human Phosphotidylinositol phosphatase PTPRQ
    Protein for Human Phosphotidylinositol phosphatase PTPRQ

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    Precision
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    Linearity
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    References
    1. 1.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    2. 2.
      "Differential expression of PTPase RNAs resulting from K562 differentiation induced by PMA."
      Dayton M.A. , Blanchard K.L.
      Submitted (1999-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2133-2266
    3. 3.
      "PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein."
      Seifert R.A. , Coats S.A. , Oganesian A. , Wright M.B. , Dishmon M. , Booth C.J. , Johnson R.J. , Alpers C.E. , Bowen-Pope D.F.
      Exp. Cell Res.287:374-386(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    4. 4.
      "Involvement of PTP-RQ in differentiation during adipogenesis of human mesenchymal stem cells."
      Jung H. , Kim W.K. , Kim do H. , Cho Y.S. , Kim S.J. , Park S.G. , Park B.C. , Lim H.M. , Bae K.H. , Lee S.C.
      Biochem. Biophys. Res. Commun.383:252-257(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    5. 5.
      "Mutations in PTPRQ are a cause of autosomal-recessive nonsyndromic hearing impairment DFNB84 and associated with vestibular dysfunction."
      Schraders M. , Oostrik J. , Huygen P.L. , Strom T.M. , van Wijk E. , Kunst H.P. , Hoefsloot L.H. , Cremers C.W. , Admiraal R.J. , Kremer H.
      Am. J. Hum. Genet.86:604-610(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;VARIANT DFNB84A GLY-281
    6. 6.
      "Nonsense mutation of the stereociliar membrane protein gene PTPRQ in human hearing loss DFNB84."
      Shahin H. , Rahil M. , Abu Rayan A. , Avraham K.B. , King M.C. , Kanaan M. , Walsh T.
      J. Med. Genet.47:643-645(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN DFNB84A;VARIANT GLU-471
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