Protein name:
Phosphotidylinositol phosphatase PTPRQ ;
Alternative:
3.1.3.48;Receptor-type tyrosine-protein phosphatase Q (PTP-RQ;R-PTP-Q) ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear. Plays an important role in adipogenesis of mesenchymal stem cells (MSCs). Regulates the phosphorylation state of AKT1 by suppressing the phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCs and preadipocyte cells.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MKKVPIKPEQ | PEKLRAFNIS | THSFSLHWSL | PSGHVERYQV | DLVPDSGFVT |
100:
IRDLGGGEYQ | VDVSNVVPGT | RYDITISSIS | TTYTSPVTRI | VTTNVTKPGP |
150:
PVFLAGERVG | SAGILLSWNT | PPNPNGRIIS | YIVKYKEVCP | WMQTVYTQVR |
200:
SKPDSLEVLL | TNLNPGTTYE | IKVAAENSAG | IGVFSDPFLF | QTAESAPGKV |
250:
VNLTVEAYNA | SAVKLIWYLP | RQPNGKITSF | KISVKHARSG | IVVKDVSIRV |
300:
EDILTGKLPE | CNENSESFLW | STASPSPTLG | RVTPPSRTTH | SSSTLTQNEI |
350:
SSVWKEPISF | VVTHLRPYTT | YLFEVSAVTT | EAGYIDSTIV | RTPESVPEGP |
400:
PQNCVTGNIT | GKSFSILWDP | PTIVTGKFSY | RVELYGPSGR | ILDNSTKDLK |
450:
FAFTNLTPFT | MYDVYIAAET | SAGTGPKSNI | SVFTPPDVPG | AVFDLQLAEV |
500:
ESTQVRITWK | KPRQPNGIIN | QYRVKVLVPE | TGIILENTLL | TGNNEYINDP |
550:
MAPEIVNIVE | PMVGLYEGSA | EMSSDLHSLA | TFIYNSHPDK | NFPARNRAED |
600:
QTSPVVTTRN | QYITDIAAEQ | LSYVIRRLVP | FTEHMISVSA | FTIMGEGPPT |
650:
VLSVRTRQQV | PSSIKIINYK | NISSSSILLY | WDPPEYPNGK | ITHYTIYAME |
700:
LDTNRAFQIT | TIDNSFLITG | LKKYTKYKMR | VAASTHVGES | SLSEENDIFV |
750:
RTSEDEPESS | PQDVEVIDVT | ADEIRLKWSP | PEKPNGIIIA | YEVLYKNIDT |
800:
LYMKNTSTTD | IILRNLRPHT | LYNISVRSYT | RFGHGNQVSS | LLSVRTSETV |
850:
PDSAPENITY | KNISSGEIEL | SFLPPSSPNG | IIKKYTIYLK | RSNGNEERTI |
900:
NTTSLTQNIK | VLKKYTQYII | EVSASTLKGE | GVRSAPISIL | TEEDAPDSPP |
950:
QDFSVKQLSG | VTVKLSWQPP | LEPNGIILYY | TVYVWNRSSL | KTINVTETSL |
1000:
ELSDLDYNVE | YSAYVTASTR | FGDGKTRSNI | ISFQTPEGAP | SDPPKDVYYA |
1050:
NLSSSSIILF | WTPPSKPNGI | IQYYSVYYRN | TSGTFMQNFT | LHEVTNDFDN |
1100:
MTVSTIIDKL | TIFSYYTFWL | TASTSVGNGN | KSSDIIEVYT | DQDIPEGFVG |
1150:
NLTYESISST | AINVSWVPPA | QPNGLVFYYV | SLILQQTPRH | VRPPLVTYER |
1200:
SIYFDNLEKY | TDYILKITPS | TEKGFSDTYT | AQLYIKTEED | VPETSPIINT |
1250:
FKNLSSTSVL | LSWDPPVKPN | GAIISYDLTL | QGPNENYSFI | TSDNYIILEE |
1300:
LSPFTLYSFF | AAARTRKGLG | PSSILFFYTD | ESVPLAPPQN | LTLINCTSDF |
1350:
VWLKWSPSPL | PGGIVKVYSF | KIHEHETDTI | YYKNISGFKT | EAKLVGLEPV |
1400:
STYSIRVSAF | TKVGNGNQFS | NVVKFTTQES | VPDVVQNMQC | MATSWQSVLV |
1450:
KWDPPKKANG | IITQYMVTVE | RNSTKVSPQD | HMYTFIKLLA | NTSYVFKVRA |
1500:
STSAGEGDES | TCHVSTLPET | VPSVPTNIAF | SDVQSTSATL | TWIRPDTILG |
1550:
YFQNYKITTQ | LRAQKCKEWE | SEECVEYQKI | QYLYEAHLTE | ETVYGLKKFR |
1600:
WYRFQVAAST | NAGYGNASNW | ISTKTLPGPP | DGPPENVHVV | ATSPFSISIS |
1650:
WSEPAVITGP | TCYLIDVKSV | DNDEFNISFI | KSNEENKTIE | IKDLEIFTRY |
1700:
SVVITAFTGN | ISAAYVEGKS | SAEMIVTTLE | SAPKDPPNNM | TFQKIPDEVT |
1750:
KFQLTFLPPS | QPNGNIQVYQ | ALVYREDDPT | AVQIHNLSII | QKTNTFVIAM |
1800:
LEGLKGGHTY | NISVYAVNSA | GAGPKVPMRI | TMDIKAPARP | KTKPTPIYDA |
1850:
TGKLLVTSTT | ITIRMPICYY | SDDHGPIKNV | QVLVTETGAQ | HDGNVTKWYD |
1900:
AYFNKARPYF | TNEGFPNPPC | TEGKTKFSGN | EEIYIIGADN | ACMIPGNEDK |
1950:
ICNGPLKPKK | QYLFKFRATN | IMGQFTDSDY | SDPVKTLGEG | LSERTVEIIL |
2000:
SVTLCILSII | LLGTAIFAFA | RIRQKQKEGG | TYSPQDAEII | DTKLKLDQLI |
2050:
TVADLELKDE | RLTRPISKKS | FLQHVEELCT | NNNLKFQEEF | SELPKFLQDL |
2100:
SSTDADLPWN | RAKNRFPNIK | PYNNNRVKLI | ADASVPGSDY | INASYISGYL |
2150:
CPNEFIATQG | PLPGTVGDFW | RMVWETRAKT | LVMLTQCFEK | GRIRCHQYWP |
2200:
EDNKPVTVFG | DIVITKLMED | VQIDWTIRDL | KIERHGDCMT | VRQCNFTAWP |
2250:
EHGVPENSAP | LIHFVKLVRA | SRAHDTTPMI | VHCSAGVGRT | GVFIALDHLT |
2300:
QHINDHDFVD | IYGLVAELRS | ERMCMVQNLA | QYIFLHQCIL | DLLSNKGSNQ |
2332:
PICFVNYSAL | QKMDSLDAME | GDVELEWEET | TM
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Human Phosphotidylinositol phosphatase PTPRQ
ELISA Kit for Human Phosphotidylinositol phosphatase PTPRQ
ELISA Kit for Human Phosphotidylinositol phosphatase PTPRQ
CLIA Kit for Human Phosphotidylinositol phosphatase PTPRQ
CLIA Kit for Human Phosphotidylinositol phosphatase PTPRQ
CLIA Kit for Human Phosphotidylinositol phosphatase PTPRQ
Polyclonal Antibody for Human Phosphotidylinositol phosphatase PTPRQ
Polyclonal Antibody for Human Phosphotidylinositol phosphatase PTPRQ
Polyclonal Antibody for Human Phosphotidylinositol phosphatase PTPRQ
Monoclonal Antibody for Human Phosphotidylinositol phosphatase PTPRQ
Monoclonal Antibody for Human Phosphotidylinositol phosphatase PTPRQ
Monoclonal Antibody for Human Phosphotidylinositol phosphatase PTPRQ
Protein for Human Phosphotidylinositol phosphatase PTPRQ
Protein for Human Phosphotidylinositol phosphatase PTPRQ
Protein for Human Phosphotidylinositol phosphatase PTPRQ
R&D Technical Data
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Precision
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Recovery
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Linearity
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Nature440:346-351(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
2.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 2133-2266
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;TISSUE SPECIFICITY
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INDUCTION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;VARIANT DFNB84A GLY-281
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN DFNB84A;VARIANT GLU-471