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Index > Protein center > RAB8A(Gene name) > Human
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  • RAB8A (Gene name),
  • Ras-related protein Rab-8A (Protein name ),  RAB8A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    RAB8A(MEL;RAB8);
    Protein name:
    Ras-related protein Rab-8A;
    Alternative:
    Oncogene c-mel;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MAP4K2 and SYTL4. Interacts with SGSM1 and SGSM3 (By similarity). Interacts with OPTN. Interacts with RAB3IP. Interacts with MYO5B.
    Function:
    May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization.
    Subcellular Location:
    Cell membrane Lipid-anchor Cytoplasmic side Golgi apparatus Cytoplasm perinuclear region Cell projection Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane. In the GDP-bound form, present in the perinuclear region. Shows a polarized distribution to distal regions of cell protrusions in the GTP-bound form. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis.
    Protein Attributes:
    Sequence length:
    207
    Sequence:
    50:
    MAKTYDYLFK | LLLIGDSGVG | KTCVLFRFSE | DAFNSTFIST | IGIDFKIRTI | 
    100:
    ELDGKRIKLQ | IWDTAGQERF | RTITTAYYRG | AMGIMLVYDI | TNEKSFDNIR | 
    150:
    NWIRNIEEHA | SADVEKMILG | NKCDVNDKRQ | VSKERGEKLA | LDYGIKFMET | 
    200:
    SAKANINVEN | AFFTLARDIK | AKMDKKLEGN | SPQGSNQGVK | ITPDQQKRSS | 
    207:
    FFRCVLL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    SMR:
    MIM:
    UniGene:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ras-related protein Rab-8A
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    E14470h
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    ELISA Kit for Human Ras-related protein Rab-8A
    MSDS:
    Please sign in first.
    ELISA Kit for Human Ras-related protein Rab-8A
    MSDS:
    Please sign in first.
    ELISA Kit for Human Ras-related protein Rab-8A
    MSDS:
    Please sign in first.
    ELISA Kit for Human Ras-related protein Rab-8A
    Cat.:
    E14470m
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Ras-related protein Rab-8A
    MSDS:
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    CLIA Kit for Human Ras-related protein Rab-8A
    MSDS:
    Please sign in first.
    CLIA Kit for Human Ras-related protein Rab-8A
    Cat.:
    U14470h
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Ras-related protein Rab-8A
    Cat.:
    U14470m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Ras-related protein Rab-8A
    MSDS:
    Please sign in first.
    CLIA Kit for Human Ras-related protein Rab-8A
    MSDS:
    Please sign in first.
    CLIA Kit for Human Ras-related protein Rab-8A
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human Ras-related protein Rab-8A
    Polyclonal Antibody for Human Ras-related protein Rab-8A
    Polyclonal Antibody for Human Ras-related protein Rab-8A
    Polyclonal Antibody for Human Ras-related protein Rab-8A
    Polyclonal Antibody for Human Ras-related protein Rab-8A
    Polyclonal Antibody for Human Ras-related protein Rab-8A
    Monoclonal Antibody for Human Ras-related protein Rab-8A
    Monoclonal Antibody for Human Ras-related protein Rab-8A
    Monoclonal Antibody for Human Ras-related protein Rab-8A
    Monoclonal Antibody for Human Ras-related protein Rab-8A
    Monoclonal Antibody for Human Ras-related protein Rab-8A
    Monoclonal Antibody for Human Ras-related protein Rab-8A
    Protein for Human Ras-related protein Rab-8A
    Protein for Human Ras-related protein Rab-8A
    Protein for Human Ras-related protein Rab-8A
    Protein for Human Ras-related protein Rab-8A
    Protein for Human Ras-related protein Rab-8A
    Protein for Human Ras-related protein Rab-8A

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells."
      Zahraoui A. , Joberty G. , Arpin M. , Fontaine J.J. , Hellio R. , Tavitian A. , Louvard D.
      J. Cell Biol.124:101-115(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "The MEL gene: a new member of the RAB/YPT class of RAS-related genes."
      Nimmo E.R. , Sanders P.G. , Padua R.A. , Hughes D. , Williamson R. , Johnson K.J.
      Oncogene6:1347-1351(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III , Ikeda S.R. , Aronstam R.S.
      Submitted (2002-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Cerebellum.
    6. 6.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 7.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Skin.
    10. 10.
      "Isoprenylation of Rab proteins possessing a C-terminal CaaX motif."
      Joberty G. , Tavitian A. , Zahraoui A.
      FEBS Lett.330:323-328(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ISOPRENYLATION AT CYS-204
    11. 11.
      "A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport."
      Hattula K. , Furuhjelm J. , Arffman A. , Peranen J.
      Mol. Biol. Cell13:3268-3280(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAB3IP;SUBCELLULAR LOCATION
      tissue: Brain.
    12. 12.
      "Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis."
      Sahlender D.A. , Roberts R.C. , Arden S.D. , Spudich G. , Taylor M.J. , Luzio J.P. , Kendrick-Jones J. , Buss F.
      J. Cell Biol.169:285-295(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH OPTN
    13. 13.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE."
      Pohl C. , Jentsch S.
      Cell132:832-845(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BIRC6/BRUCE
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "Pitchfork regulates primary cilia disassembly and left-right asymmetry."
      Kinzel D. , Boldt K. , Davis E.E. , Burtscher I. , Trumbach D. , Diplas B. , Attie-Bitach T. , Wurst W. , Katsanis N. , Ueffing M. , Lickert H.
      Dev. Cell19:66-77(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIFO
    18. 18.
      "A molecular network for de novo generation of the apical surface and lumen."
      Bryant D.M. , Datta A. , Rodriguez-Fraticelli A.E. , Peraenen J. , Martin-Belmonte F. , Mostov K.E.
      Nat. Cell Biol.12:1035-1045(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    19. 19.
      "MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling."
      Sharma M. , Giridharan S.S. , Rahajeng J. , Naslavsky N. , Caplan S.
      Mol. Biol. Cell20:5181-5194(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH EHD1 AND MICALL1;MUTAGENESIS OF THR-22 AND GLN-67
    20. 20.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181 AND SER-185;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 22.
      "Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization."
      Roland J.T. , Bryant D.M. , Datta A. , Itzen A. , Mostov K.E. , Goldenring J.R.
      Proc. Natl. Acad. Sci. U.S.A.108:2789-2794(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MYO5B
    23. 23.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    24. 24.
      "Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes."
      Seto S. , Tsujimura K. , Koide Y.
      Traffic12:407-420(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    25. 25.
      "A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo."
      Chen Y. , Wu B. , Xu L. , Li H. , Xia J. , Yin W. , Li Z. , Shi D. , Li S. , Lin S. , Shu X. , Pei D.
      Cell Res.22:333-345(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CILIOGENESIS;SUBCELLULAR LOCATION
    26. 26.
      "OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome."
      Luo N. , West C.C. , Murga-Zamalloa C.A. , Sun L. , Anderson R.M. , Wells C.D. , Weinreb R.N. , Travers J.B. , Khanna H. , Sun Y.
      Hum. Mol. Genet.21:3333-3344(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH OCRL
    27. 27.
      "A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1."
      Hou X. , Hagemann N. , Schoebel S. , Blankenfeldt W. , Goody R.S. , Erdmann K.S. , Itzen A.
      EMBO J.30:1659-1670(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 6-176 IN COMPLEX WITH OCRL
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