Gene name:
RAB8A (MEL;RAB8) ;
Protein name:
Ras-related protein Rab-8A ;
Alternative:
Oncogene c-mel ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with MAP4K2 and SYTL4. Interacts with SGSM1 and SGSM3 (By similarity). Interacts with OPTN. Interacts with RAB3IP. Interacts with MYO5B.
Function:
May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization.
Subcellular Location:
Cell membrane
Lipid-anchor
Cytoplasmic side
Golgi apparatus
Cytoplasm
perinuclear region
Cell projection
Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane. In the GDP-bound form, present in the perinuclear region. Shows a polarized distribution to distal regions of cell protrusions in the GTP-bound form. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis.
Protein Attributes:
50:
MAKTYDYLFK | LLLIGDSGVG | KTCVLFRFSE | DAFNSTFIST | IGIDFKIRTI |
100:
ELDGKRIKLQ | IWDTAGQERF | RTITTAYYRG | AMGIMLVYDI | TNEKSFDNIR |
150:
NWIRNIEEHA | SADVEKMILG | NKCDVNDKRQ | VSKERGEKLA | LDYGIKFMET |
200:
SAKANINVEN | AFFTLARDIK | AKMDKKLEGN | SPQGSNQGVK | ITPDQQKRSS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Dog
Rat
Mouse
Chicken
ELISA Kit for Human Ras-related protein Rab-8A
ELISA Kit for Human Ras-related protein Rab-8A
ELISA Kit for Human Ras-related protein Rab-8A
ELISA Kit for Human Ras-related protein Rab-8A
ELISA Kit for Human Ras-related protein Rab-8A
ELISA Kit for Human Ras-related protein Rab-8A
CLIA Kit for Human Ras-related protein Rab-8A
CLIA Kit for Human Ras-related protein Rab-8A
CLIA Kit for Human Ras-related protein Rab-8A
CLIA Kit for Human Ras-related protein Rab-8A
CLIA Kit for Human Ras-related protein Rab-8A
CLIA Kit for Human Ras-related protein Rab-8A
Polyclonal Antibody for Human Ras-related protein Rab-8A
Polyclonal Antibody for Human Ras-related protein Rab-8A
Polyclonal Antibody for Human Ras-related protein Rab-8A
Polyclonal Antibody for Human Ras-related protein Rab-8A
Polyclonal Antibody for Human Ras-related protein Rab-8A
Polyclonal Antibody for Human Ras-related protein Rab-8A
Monoclonal Antibody for Human Ras-related protein Rab-8A
Monoclonal Antibody for Human Ras-related protein Rab-8A
Monoclonal Antibody for Human Ras-related protein Rab-8A
Monoclonal Antibody for Human Ras-related protein Rab-8A
Monoclonal Antibody for Human Ras-related protein Rab-8A
Monoclonal Antibody for Human Ras-related protein Rab-8A
Protein for Human Ras-related protein Rab-8A
Protein for Human Ras-related protein Rab-8A
Protein for Human Ras-related protein Rab-8A
Protein for Human Ras-related protein Rab-8A
Protein for Human Ras-related protein Rab-8A
Protein for Human Ras-related protein Rab-8A
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Brain .
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[
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Europe PMC ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Cerebellum .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Skin .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ISOPRENYLATION AT CYS-204
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RAB3IP;SUBCELLULAR LOCATION
tissue :
Brain .
12.
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Cited for : SUBCELLULAR LOCATION;INTERACTION WITH OPTN
13.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH BIRC6/BRUCE
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.
"Pitchfork regulates primary cilia disassembly and left-right asymmetry."
Kinzel D.
,
Boldt K.
,
Davis E.E.
,
Burtscher I.
,
Trumbach D.
,
Diplas B.
,
Attie-Bitach T.
,
Wurst W.
,
Katsanis N.
,
Ueffing M.
,
Lickert H.
Dev. Cell19:66-77(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PIFO
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;INTERACTION WITH EHD1 AND MICALL1;MUTAGENESIS OF THR-22 AND GLN-67
20.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181 AND SER-185;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
21.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH MYO5B
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
25.
"A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo."
Chen Y.
,
Wu B.
,
Xu L.
,
Li H.
,
Xia J.
,
Yin W.
,
Li Z.
,
Shi D.
,
Li S.
,
Lin S.
,
Shu X.
,
Pei D.
Cell Res.22:333-345(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN CILIOGENESIS;SUBCELLULAR LOCATION
26.
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Cited for : INTERACTION WITH OCRL
27.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 6-176 IN COMPLEX WITH OCRL