Protein name:
ATP-dependent DNA helicase Q5 ;
Alternative:
RECQL5beta ;DNA helicase, RecQ-like type 5 (RecQ5) ;RecQ protein-like 5 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Monomer. Interacts with TOP2A, TOP3A and TOP3B. Interacts with RNA polymerase II subunit POLR2A. Identified in a complex with the RNA polymerase II core bound to DNA. Interacts with RAD51.
Function:
DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.
Subcellular Location:
Nucleus
Nucleoplasm
Recruited to sites of DNA damage, such as single-strand breaks and inter-strand cross-links, and at stalled replication forks.
Protein Attributes:
50:
MSARPFSTPF | DRERRVRSTL | KKVFGFDSFK | TPLQESATMA | VVKGAEDVFV |
100:
CMPTGAGKSL | CYQLPALLAS | GITIVVSPLI | ALIQDQVDHL | LALKVQVSSL |
150:
NSKLSVQERK | ELLSDLERDK | PRTKLLYITP | EMAASASFQP | TLNSLVSRNL |
200:
LSYLVVDEAH | CVSQWGHDFR | PDYLRLGALR | SRLAHAPCVA | LTATATPQVQ |
250:
EDVFAALHLK | QPVASFKTPC | FRANLFYDVQ | FKELIPDVYG | NLRDFCLKAL |
300:
GQKAENGSSS | GCGIVYCRTR | EACEQLAIEL | SSRGVNAKAY | HAGLKASDRT |
350:
QVQNEWMEEK | VPVIVATISF | GMGVDKANVR | FVAHWNIAKS | MAGYYQESGR |
400:
AGRDGKPSWC | RLYYSRNDRD | QVSFLIRKEL | AKLQEKRGNK | PSDKATLLAF |
450:
DALVTFCEEV | GCRHAAIAKY | FGDAPPACAK | GCDYCQNPAA | ITKKLDALER |
500:
SSSWSKTCIG | PSQGNGFDPE | LYEGGRRGYG | GFSRYDEGSG | GSGDEGRDEA |
550:
HKREWNLFYQ | KQMSLRKGKE | PKIEEFTPPD | EDCPLREASS | RKIPKLTVKA |
600:
REHCLRLLEE | ALISNHQAAG | STHGADLQAK | AVELEHETFR | NAKMVNLYKA |
650:
SVLKKVAEIH | KASKDGQLYD | MESGTKSCGA | AAEFSEPSDY | DIPPTSHVYS |
700:
LKPKRVGAGF | SKGPCSFQTA | TELLGKSHSQ | KQAPEAMLEG | GQEPPGWVCD |
750:
LQDEDRSKPH | PGYQEKALGS | SVNCGDPSPE | KKTKGSSQGS | AKARASKKQQ |
800:
LLATAARKDS | QNITRFLCQR | TESPPLPASV | PRSEDASPSC | GDVPGKCTQE |
850:
VGAQGHLVAV | FQTEGPRERP | STCSLRDQSF | PEGQPSPLKE | TQAEKRPRPQ |
900:
QGNPERRAQK | RLRPSTKSSI | LAEAKDSTLA | SDRSTENKVA | QEPCQLSASG |
950:
TSLREAADIV | VRHLTPFYKE | GRFISKDLFK | GFARHLSHLL | AQQLSPGRSV |
982:
KEEAQSLIKQ | FFHNRARCES | EADWHSLRGP | QR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Mouse ATP-dependent DNA helicase Q5
ELISA Kit for Mouse ATP-dependent DNA helicase Q5
ELISA Kit for Mouse ATP-dependent DNA helicase Q5
CLIA Kit for Mouse ATP-dependent DNA helicase Q5
CLIA Kit for Mouse ATP-dependent DNA helicase Q5
CLIA Kit for Mouse ATP-dependent DNA helicase Q5
Polyclonal Antibody for Mouse ATP-dependent DNA helicase Q5
Polyclonal Antibody for Mouse ATP-dependent DNA helicase Q5
Polyclonal Antibody for Mouse ATP-dependent DNA helicase Q5
Monoclonal Antibody for Mouse ATP-dependent DNA helicase Q5
Monoclonal Antibody for Mouse ATP-dependent DNA helicase Q5
Monoclonal Antibody for Mouse ATP-dependent DNA helicase Q5
Protein for Mouse ATP-dependent DNA helicase Q5
Protein for Mouse ATP-dependent DNA helicase Q5
Protein for Mouse ATP-dependent DNA helicase Q5
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 234-982
strain :
C57BL/6J .
tissue :
Embryo .