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Index > Protein center > REG1A(Gene name) > Human
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  • REG1A (Gene name),
  • Lithostathine-1-alpha (Protein name ),  REG1A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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    • Gene name:
    REG1A(PSPS;PSPS1;REG);
    Protein name:
    Lithostathine-1-alpha;
    Alternative:
    Islet of Langerhans regenerating protein(REG);Islet cells regeneration factor(ICRF);Pancreatic thread protein(PTP);Pancreatic stone protein(PSP);Regenerating protein I alpha;Regenerating islet-derived protein 1-alpha(REG-1-alpha);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    166
    Sequence:
    50:
    MAQTSSYFML | ISCLMFLSQS | QGQEAQTELP | QARISCPEGT | NAYRSYCYYF | 
    100:
    NEDRETWVDA | DLYCQNMNSG | NLVSVLTQAE | GAFVASLIKE | SGTDDFNVWI | 
    150:
    GLHDPKKNRR | WHWSSGSLVS | YKSWGIGAPS | SVNPGYCVSL | TSSTGFQKWK | 
    166:
    DVPCEDKFSF | VCKFKN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Hs.4158
    Pfam:
    PF00059
    SMR:
    P05451
    MIM:
    167770
    STRING:
    9606.ENSP00000233735
    String:
    P05451
    KEGG:
    hsa:5967
    Uniprot:
    P05451
     
    FOR
    ELISA Kit for Human Lithostathine-1-alpha
    Cat.:
    E1760h
    Price:
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    Manual:
    Looking for manual.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Lithostathine-1-alpha
    Cat.:
    U1760h
    Price:
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    Manual:
    Looking for manual.
    MSDS:
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    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human Lithostathine-1-alpha
    Cat.:
    P1760Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Lithostathine-1-alpha
    Protein for Human Lithostathine-1-alpha

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene."
      Watanabe T. , Yonekura H. , Terazono K. , Yamamoto H. , Okamoto H.
      J. Biol. Chem.265:7432-7439(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis."
      Giorgi D. , Bernard J.-P. , Rouquier S. , Iovanna J. , Sarles H. , Dagorn J.-C.
      J. Clin. Invest.84:100-106(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
      tissue: Pancreas.
    4. 4.
      Boonyasrisawat W. , Tandhanand-Banchuin N. , Vannasaeng S. , Yenchitsomanus P.
      Submitted (1999-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    5. 5.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Pancreas.
    8. 8.
      "Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice."
      de Caro A.M. , Bonicel J.J. , Rouimi P. , de Caro J.D. , Sarles H. , Rovery M.
      Eur. J. Biochem.168:201-207(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 34-166
    9. 9.
      "Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein."
      Montalto G. , Bonicel J.J. , Multigner L. , Rovery M. , Sarles H. , de Caro A.M.
      Biochem. J.238:227-232(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 34-98
    10. 10.
      "Isolation, characterization, and distribution of an unusual pancreatic human secretory protein."
      Gross J. , Carlson R.I. , Brauer A.W. , Margolies M.N. , Warshaw A.L. , Wands J.R.
      J. Clin. Invest.76:2115-2125(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 34-78
    11. 11.
      "N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue."
      de Caro A.M. , Adrich Z. , Fournet B. , Capon C. , Bonicel J.J. , de Caro J.D. , Rovery M.
      Biochim. Biophys. Acta994:281-284(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-47;PYROGLUTAMATE FORMATION AT GLN-23;GLYCOSYLATION AT THR-27
    12. 12.
      "Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein."
      Rouimi P. , Bonicel J. , Rovery M. , de Caro A.
      FEBS Lett.216:195-199(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 33-58
    13. 13.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-37
    14. 14.
      "The human reg gene encodes pancreatic stone protein."
      Stewart T.A.
      Biochem. J.260:622-623(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTITY OF REG WITH PSP
    15. 15.
      "Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae."
      Itoh T. , Tsuzuki H. , Katoh T. , Teraoka H. , Matsumoto K. , Yoshida N. , Terazono K. , Watanabe T. , Yonekura H. , Yamamoto H. , Okamoto H.
      FEBS Lett.272:85-88(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    16. 16.
      "Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain."
      de la Monte S.M. , Ozturk M. , Wands J.R.
      J. Clin. Invest.86:1004-1013(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    17. 17.
      "Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation."
      Bertrand J.A. , Pignol D. , Bernard J.-P. , Verdier J.-M. , Dagorn J.-C. , Fontecilla-Camps J.-C.
      EMBO J.15:2678-2684(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS)
    18. 18.
      "Mechanism of calcite crystal growth inhibition by the N-terminal undecapeptide of lithostathine."
      Gerbaud V. , Pignol D. , Loret E. , Bertrand J.A. , Berland Y. , Fontecilla-Camps J.-C. , Canselier J.P. , Gabas N. , Verdier J.-M.
      J. Biol. Chem.275:1057-1064(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 23-166
    19. 19.
      "What function for human lithostathine?: structural investigations by three-dimensional structure modeling and high-resolution NMR spectroscopy."
      Patard L. , Stoven V. , Gharib B. , Bontems F. , Lallemand J.-Y. , de Reggi M.
      Protein Eng.9:949-957(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 34-164
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