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Index > Protein center > RSPO1(Gene name) > Human
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  • RSPO1 (Gene name),
  • R-spondin-1 (Protein name ),  RSPO1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    RSPO1;
    Protein name:
    R-spondin-1;
    Alternative:
    Roof plate-specific spondin-1(hRspo1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with the extracelular domain of FZD8 and LRP6. It however does not form a ternary complex with FZD8 and LRP6. Interacts with WNT1. Binds heparin.
    Function:
    Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    263
    Sequence:
    50:
    MRLGLCVVAL | VLSWTHLTIS | SRGIKGKRQR | RISAEGSQAC | AKGCELCSEV | 
    100:
    NGCLKCSPKL | FILLERNDIR | QVGVCLPSCP | PGYFDARNPD | MNKCIKCKIE | 
    150:
    HCEACFSHNF | CTKCKEGLYL | HKGRCYPACP | EGSSAANGTM | ECSSPAQCEM | 
    200:
    SEWSPWGPCS | KKQQLCGFRR | GSEERTRRVL | HAPVGDHAAC | SDTKETRRCT | 
    250:
    VRRVPCPEGQ | KRRKGGQGRR | ENANRNLARK | ESKEAGAGSR | RRKGQQQQQQ | 
    263:
    QGTVGPLTSA | GPA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human R-spondin-1
    Cat.:
    E3285h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human R-spondin-1
    Cat.:
    E3285m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human R-spondin-1
    Cat.:
    U3285m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human R-spondin-1
    Cat.:
    U3285h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human R-spondin-1
    Cat.:
    P3285Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human R-spondin-1
    Cat.:
    P3285Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human R-spondin-1
    Monoclonal Antibody for Human R-spondin-1
    Protein for Human R-spondin-1
    Protein for Human R-spondin-1

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Mitogenic influence of human R-spondin1 on the intestinal epithelium."
      Kim K.-A. , Kakitani M. , Zhao J. , Oshima T. , Tang T. , Binnerts M. , Liu Y. , Boyle B. , Park E. , Emtage P. , Funk W.D. , Tomizuka K.
      Science309:1256-1259(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
    2. 2.
      "R-spondin1 is essential in sex determination, skin differentiation and malignancy."
      Parma P. , Radi O. , Vidal V. , Chaboissier M.C. , Dellambra E. , Valentini S. , Guerra L. , Schedl A. , Camerino G.
      Nat. Genet.38:1304-1309(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3);TISSUE SPECIFICITY;INVOLVEMENT IN PALMOPLANTAR HYPERKERATOSIS WITH SQUAMOUS CELL CARCINOMA OF SKIN AND SEX REVERSAL
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Uterus.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ZNRF3
    7. 7.
      "LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling."
      Glinka A. , Dolde C. , Kirsch N. , Huang Y.L. , Kazanskaya O. , Ingelfinger D. , Boutros M. , Cruciat C.M. , Niehrs C.
      EMBO Rep.12:1055-1061(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LGR4 AND LGR5
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LGR4; LGR5 AND LGR6
    9. 9.
      "LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor."
      Gong X. , Carmon K.S. , Lin Q. , Thomas A. , Yi J. , Liu Q.
      PLoS ONE7:E37137-E37137(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LGR6
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LGR4 AND LGR5
    11. 11.
      "Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5."
      Peng W.C. , de Lau W. , Forneris F. , Granneman J.C. , Huch M. , Clevers H. , Gros P.
      Cell Rep.3:1885-1892(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 31-146 IN COMPLEX WITH LGR5;FUNCTION;INTERACTION WITH LGR5;MUTAGENESIS OF ARG-66; ARG-70; GLN-71; GLY-73; ARG-87; PHE-106 AND PHE-110;DISULFIDE BONDS
    12. 12.
      "Structural basis for R-spondin recognition by LGR4/5/6 receptors."
      Wang D. , Huang B. , Zhang S. , Yu X. , Wu W. , Wang X.
      Genes Dev.27:1339-1344(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 39-128 IN COMPLEX WITH LGR4;FUNCTION;SUBUNIT;MUTAGENESIS OF ARG-87; PHE-106; PHE-110; LYS-122 AND ARG-124;DISULFIDE BONDS
    13. 13.
      "The structural basis of R-spondin recognition by LGR5 and RNF43."
      Chen P.H. , Chen X. , Lin Z. , Fang D. , He X.
      Genes Dev.27:1345-1350(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 35-144 IN COMPLEX WITH LGR5 AND RNF43;SUBUNIT;DISULFIDE BONDS
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