RSPO1 ELISA Kit for Human(Homo sapiens) | EIAab.comRSPO1 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > RSPO1(Gene name) > Human

RSPO1 (Gene name),

R-spondin-1 (Protein name ), RSPO1_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

RSPO1;

Protein name:

R-spondin-1;

Alternative:

Roof plate-specific spondin-1(hRspo1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with the extracelular domain of FZD8 and LRP6. It however does not form a ternary complex with FZD8 and LRP6. Interacts with WNT1. Binds heparin.

Function:

Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

263

Sequence:

50:

100:

150:

200:

250:

263:

QGTVGPLTSA | GPA

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

STRING:

9606.ENSP00000348944

UniGene:

Hs.135015

Pfam:

PF00090

KEGG:

hsa:284654

String:

Q2MKA7

MIM:

609595

SMR:

Q2MKA7

Uniprot:

Q2MKA7

FOR

ELISA Kit for Human R-spondin-1

Cat.:

E3285h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human R-spondin-1

Cat.:

E3285m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human R-spondin-1

Cat.:

U3285m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human R-spondin-1

Cat.:

U3285h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human R-spondin-1

Cat.:

P3285Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human R-spondin-1

Cat.:

P3285Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human R-spondin-1

Protein for Human R-spondin-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Mitogenic influence of human R-spondin1 on the intestinal epithelium."
Kim K.-A. , Kakitani M. , Zhao J. , Oshima T. , Tang T. , Binnerts M. , Liu Y. , Boyle B. , Park E. , Emtage P. , Funk W.D. , Tomizuka K.
Science309:1256-1259(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
2.

"R-spondin1 is essential in sex determination, skin differentiation and malignancy."
Parma P. , Radi O. , Vidal V. , Chaboissier M.C. , Dellambra E. , Valentini S. , Guerra L. , Schedl A. , Camerino G.
Nat. Genet.38:1304-1309(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3);TISSUE SPECIFICITY;INVOLVEMENT IN PALMOPLANTAR HYPERKERATOSIS WITH SQUAMOUS CELL CARCINOMA OF SKIN AND SEX REVERSAL
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Uterus.
4.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.

"ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner."
Hao H.X. , Xie Y. , Zhang Y. , Charlat O. , Oster E. , Avello M. , Lei H. , Mickanin C. , Liu D. , Ruffner H. , Mao X. , Ma Q. , Zamponi R. , Bouwmeester T. , Finan P.M. , Kirschner M.W. , Porter J.A. , Serluca F.C. , more...
Nature485:195-200(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ZNRF3
7.

"LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling."
Glinka A. , Dolde C. , Kirsch N. , Huang Y.L. , Kazanskaya O. , Ingelfinger D. , Boutros M. , Cruciat C.M. , Niehrs C.
EMBO Rep.12:1055-1061(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LGR4 AND LGR5
8.

"Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling."
de Lau W. , Barker N. , Low T.Y. , Koo B.K. , Li V.S. , Teunissen H. , Kujala P. , Haegebarth A. , Peters P.J. , van de Wetering M. , Stange D.E. , van Es J.E. , Guardavaccaro D. , Schasfoort R.B. , Mohri Y. , Nishimori K. , Mohammed S. , Heck A.J. , more...
Nature476:293-297(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LGR4; LGR5 AND LGR6
9.

"LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor."
Gong X. , Carmon K.S. , Lin Q. , Thomas A. , Yi J. , Liu Q.
PLoS ONE7:E37137-E37137(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LGR6
10.

"R-Spondin potentiates Wnt/beta-catenin signaling through orphan receptors LGR4 and LGR5."
Ruffner H. , Sprunger J. , Charlat O. , Leighton-Davies J. , Grosshans B. , Salathe A. , Zietzling S. , Beck V. , Therier M. , Isken A. , Xie Y. , Zhang Y. , Hao H. , Shi X. , Liu D. , Song Q. , Clay I. , Hintzen G. , more...
PLoS ONE7:E40976-E40976(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LGR4 AND LGR5
11.

"Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5."
Peng W.C. , de Lau W. , Forneris F. , Granneman J.C. , Huch M. , Clevers H. , Gros P.
Cell Rep.3:1885-1892(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 31-146 IN COMPLEX WITH LGR5;FUNCTION;INTERACTION WITH LGR5;MUTAGENESIS OF ARG-66; ARG-70; GLN-71; GLY-73; ARG-87; PHE-106 AND PHE-110;DISULFIDE BONDS
12.

"Structural basis for R-spondin recognition by LGR4/5/6 receptors."
Wang D. , Huang B. , Zhang S. , Yu X. , Wu W. , Wang X.
Genes Dev.27:1339-1344(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 39-128 IN COMPLEX WITH LGR4;FUNCTION;SUBUNIT;MUTAGENESIS OF ARG-87; PHE-106; PHE-110; LYS-122 AND ARG-124;DISULFIDE BONDS
13.

"The structural basis of R-spondin recognition by LGR5 and RNF43."
Chen P.H. , Chen X. , Lin Z. , Fang D. , He X.
Genes Dev.27:1345-1350(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 35-144 IN COMPLEX WITH LGR5 AND RNF43;SUBUNIT;DISULFIDE BONDS

Product Feedback Wall

* Email:
*Comments: