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Index > Protein center > RXRB(Gene name) > Human
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  • RXRB (Gene name),
  • Retinoic acid receptor RXR-beta (Protein name ),  RXRB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    RXRB(NR2B2);
    Protein name:
    Retinoic acid receptor RXR-beta;
    Alternative:
    Retinoid X receptor beta;Nuclear receptor subfamily 2 group B member 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer (By similarity). Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer.
    Function:
    Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Specifically binds 9-cis retinoic acid (9C-RA).
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    533
    Sequence:
    50:
    MSWAARPPFL | PQRHAAGQCG | PVGVRKEMHC | GVASRWRRRR | PWLDPAAAAA | 
    100:
    AAVAGGEQQT | PEPEPGEAGR | DGMGDSGRDS | RSPDSSSPNP | LPQGVPPPSP | 
    150:
    PGPPLPPSTA | PSLGGSGAPP | PPPMPPPPLG | SPFPVISSSM | GSPGLPPPAP | 
    200:
    PGFSGPVSSP | QINSTVSLPG | GGSGPPEDVK | PPVLGVRGLH | CPPPPGGPGA | 
    250:
    GKRLCAICGD | RSSGKHYGVY | SCEGCKGFFK | RTIRKDLTYS | CRDNKDCTVD | 
    300:
    KRQRNRCQYC | RYQKCLATGM | KREAVQEERQ | RGKDKDGDGE | GAGGAPEEMP | 
    350:
    VDRILEAELA | VEQKSDQGVE | GPGGTGGSGS | SPNDPVTNIC | QAADKQLFTL | 
    400:
    VEWAKRIPHF | SSLPLDDQVI | LLRAGWNELL | IASFSHRSID | VRDGILLATG | 
    450:
    LHVHRNSAHS | AGVGAIFDRV | LTELVSKMRD | MRMDKTELGC | LRAIILFNPD | 
    500:
    AKGLSNPSEV | EVLREKVYAS | LETYCKQKYP | EQQGRFAKLL | LRLPALRSIG | 
    533:
    LKCLEHLFFF | KLIGDTPIDT | FLMEMLEAPH | QLA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    UniGene:
    SMR:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Retinoic acid receptor RXR-beta
    Cat.:
    E10636h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Retinoic acid receptor RXR-beta
    Cat.:
    E10636m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Retinoic acid receptor RXR-beta
    MSDS:
    Please sign in first.
    ELISA Kit for Human Retinoic acid receptor RXR-beta
    Cat.:
    E10636r
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Retinoic acid receptor RXR-beta
    Cat.:
    U10636r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Retinoic acid receptor RXR-beta
    MSDS:
    Please sign in first.
    CLIA Kit for Human Retinoic acid receptor RXR-beta
    Cat.:
    U10636m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Retinoic acid receptor RXR-beta
    Cat.:
    U10636h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Retinoic acid receptor RXR-beta
    Polyclonal Antibody for Human Retinoic acid receptor RXR-beta
    Polyclonal Antibody for Human Retinoic acid receptor RXR-beta
    Polyclonal Antibody for Human Retinoic acid receptor RXR-beta
    Cat.:
    P10636Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Retinoic acid receptor RXR-beta
    Monoclonal Antibody for Human Retinoic acid receptor RXR-beta
    Monoclonal Antibody for Human Retinoic acid receptor RXR-beta
    Monoclonal Antibody for Human Retinoic acid receptor RXR-beta
    Protein for Human Retinoic acid receptor RXR-beta
    Protein for Human Retinoic acid receptor RXR-beta
    Protein for Human Retinoic acid receptor RXR-beta
    Protein for Human Retinoic acid receptor RXR-beta

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently."
      Leid M. , Kastner P. , Lyons R. , Nakshatri H. , Saunders M. , Zacharewsi T. , Chen J.Y. , Staub A. , Garnier J.-M. , Mader S. , Chambon P.
      Cell68:377-395(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);HETERODIMERIZATION
      tissue: Mammary carcinoma.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM;SEQUENCE REVISION
    3. 3.
      "Isolation of a full-length cDNA clone encoding a N-terminally variant form of the human retinoid X receptor beta."
      Fleischhauer K. , Park J.H. , Disanto J.P. , Marks M.S. , Ozato K. , Yang S.Y.
      Nucleic Acids Res.20:1801-1801(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      Numasawa T. , Koga H. , Ueyama K. , Maeda S. , Sakou T. , Harata S. , Leppert M. , Inoue I.
      Submitted (1998-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Isolation of cDNA coding for putatively new variants of multiple human nuclear receptors."
      Kaighin V.A. , Martin A.L. , Aronstam R.S.
      Submitted (2010-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Liver.
    6. 6.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    7. 7.
      "Molecular cloning and characterization of the human HRXRB gene and 5' flanking region."
      Corella A. , Vergara A. , Paez G. , de Miguel C. , Encio I.
      Submitted (1999-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    8. 8.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    10. 10.
      "Cloning and chromosome mapping of human retinoid X receptor beta: selective amino acid sequence conservation of a nuclear hormone receptor in mammals."
      Fleischhauer K. , McBride O.W. , DiSanto J.P. , Ozato K. , Yang S.Y.
      Hum. Genet.90:505-510(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 161-331 (ISOFORM 1);TISSUE SPECIFICITY
    11. 11.
      "The structural basis for the specificity of retinoid-X receptor-selective agonists: new insights into the role of helix H12."
      Love J.D. , Gooch J.T. , Benko S. , Li C. , Nagy L. , Chatterjee V.K. , Evans R.M. , Schwabe J.W.
      J. Biol. Chem.277:11385-11391(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 299-522 IN COMPLEX WITH THE RXR-SPECIFIC AGONIST LG100268
    12. 12.
      "Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation."
      Svensson S. , Ostberg T. , Jacobsson M. , Norstrom C. , Stefansson K. , Hallen D. , Johansson I.C. , Zachrisson K. , Ogg D. , Jendeberg L.
      EMBO J.22:4625-4633(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 298-533 IN COMPLEX WITH NR1H3
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