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Index > Protein center > S100A9(Gene name) > Human
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  • S100A9 (Gene name),
  • Protein S100-A9 (Protein name ),  S10A9_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    S100A9(CAGB;CFAG;MRP14);
    Protein name:
    Protein S100-A9;
    Alternative:
    Calprotectin L1H subunit;Calgranulin-B;Migration inhibitory factor-related protein 14(MRP-14;p14);Leukocyte L1 complex heavy chain;S100 calcium-binding protein A9;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Heterotetramer with S100A8. Component of the heterotetrameric calprotectin complex containing two copies each of S100A8 and S100A9. Interacts with CEACAM3 and tubulin filaments in a calcium-dependent manner. Heterotetrameric calprotectin interacts with ANXA6 and associates with tubulin filaments in activated monocytes. May interact with components of the intermediate filaments in monocytes and epithelial cells. The homodimer interacts with AGER and with the heterodimeric complex formed by TLR4 and LY96 in the presence of calcium and/or zinc ions. The homodimer binds quinoline-3-carboxamides in the presence of calcium and/or zinc ions.
    Function:
    Calcium-binding protein. Has antimicrobial activity towards bacteria and fungi. Important for resistance to invasion by pathogenic bacteria. Up-regulates transcription of genes that are under the control of NF-kappa-B. Plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS) (By similarity). Promotes tubulin polymerization when unphosphorylated. Promotes phagocyte migration and infiltration of granulocytes at sites of wounding. Plays a role as a pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1. Extracellular calprotectin binds to target cells and promotes apoptosis. Antimicrobial and proapoptotic activity is inhibited by zinc ions.
    Subcellular Location:
    Secreted Cytoplasm Cytoplasm cytoskeleton Cell membrane Peripheral membrane protein Associates with tubulin filaments in activated monocytes. Targeted to the cell surface upon calcium influx. Released from blood leukocytes upon exposure to CSF2/GM-CSF, bacterial lipopolysaccharide (LPS) and during inflammatory processes. Serum levels are high in patients suffering from chronic inflammation.
    Protein Attributes:
    Sequence length:
    114
    Sequence:
    50:
    MTCKMSQLER | NIETIINTFH | QYSVKLGHPD | TLNQGEFKEL | VRKDLQNFLK | 
    100:
    KENKNEKVIE | HIMEDLDTNA | DKQLSFEEFI | MLMARLTWAS | HEKMHEGDEG | 
    114:
    PGHHHKPGLG | EGTP
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    String:
    MIM:
    Pfam:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein S100-A9
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    ELISA Kit for Human Protein S100-A9
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    ELISA Kit for Human Protein S100-A9
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    E1793r
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    ELISA Kit for Human Protein S100-A9
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    E1793b
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    ELISA Kit for Human Protein S100-A9
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    CLIA Kit for Human Protein S100-A9
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    CLIA Kit for Human Protein S100-A9
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    U1793m
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    96T
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    CLIA Kit for Human Protein S100-A9
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    U1793h
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    96T
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    CLIA Kit for Human Protein S100-A9
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    U1793b
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    96T
    CLIA Kit for Human Protein S100-A9
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    U1793r
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    Packing:
    96T
    Polyclonal Antibody for Human Protein S100-A9
    Polyclonal Antibody for Human Protein S100-A9
    Polyclonal Antibody for Human Protein S100-A9
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    P1793Rb-h
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    Polyclonal Antibody for Human Protein S100-A9
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    P1793Rb-r
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    Polyclonal Antibody for Human Protein S100-A9
    Cat.:
    P1793Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Protein S100-A9
    Monoclonal Antibody for Human Protein S100-A9
    Monoclonal Antibody for Human Protein S100-A9
    Monoclonal Antibody for Human Protein S100-A9
    Monoclonal Antibody for Human Protein S100-A9
    Protein for Human Protein S100-A9
    Protein for Human Protein S100-A9
    Protein for Human Protein S100-A9
    Protein for Human Protein S100-A9
    Protein for Human Protein S100-A9

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
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      tissue: Keratinocyte.
    12. 12.
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      "Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion."
      Ryckman C. , Vandal K. , Rouleau P. , Talbot M. , Tessier P.A.
      J. Immunol.170:3233-3242(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    16. 16.
      "MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes."
      Vogl T. , Ludwig S. , Goebeler M. , Strey A. , Thorey I.S. , Reichelt R. , Foell D. , Gerke V. , Manitz M.P. , Nacken W. , Werner S. , Sorg C. , Roth J.
      Blood104:4260-4268(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TUBULIN;PHOSPHORYLATION AT THR-113
    17. 17.
      "Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells."
      Viemann D. , Strey A. , Janning A. , Jurk K. , Klimmek K. , Vogl T. , Hirono K. , Ichida F. , Foell D. , Kehrel B. , Gerke V. , Sorg C. , Roth J.
      Blood105:2955-2962(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;IDENTIFICATION BY MASS SPECTROMETRY
    18. 18.
      "The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2."
      Kerkhoff C. , Nacken W. , Benedyk M. , Dagher M.C. , Sopalla C. , Doussiere J.
      FASEB J.19:467-469(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NCF2/P67PHOX; RAC1 AND RAC2
    19. 19.
      "Myeloid-related protein-14 is a p38 MAPK substrate in human neutrophils."
      Lominadze G. , Rane M.J. , Merchant M. , Cai J. , Ward R.A. , McLeish K.R.
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      Mediators Inflamm.2005:280-292(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INHIBITION BY ZINC IONS;SUBUNIT
    21. 21.
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      Bode G. , Lueken A. , Kerkhoff C. , Roth J. , Ludwig S. , Nacken W.
      J. Biol. Chem.283:31776-31784(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH ANXA6
    22. 22.
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      Carrascal M. , Ovelleiro D. , Casas V. , Gay M. , Abian J.
      J. Proteome Res.7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-113;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: T-cell.
    23. 23.
      "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G. , Ye M. , Zhou H. , Jiang X. , Feng S. , Jiang X. , Tian R. , Wan D. , Zou H. , Gu J.
      Proteomics8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-113;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    24. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    25. 25.
      "A novel p53 target gene, S100A9, induces p53-dependent cellular apoptosis and mediates the p53 apoptosis pathway."
      Li C. , Chen H. , Ding F. , Zhang Y. , Luo A. , Wang M. , Liu Z.
      Biochem. J.422:363-372(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    26. 26.
      "S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis."
      Ghavami S. , Chitayat S. , Hashemi M. , Eshraghi M. , Chazin W.J. , Halayko A.J. , Kerkhoff C.
      Eur. J. Pharmacol.625:73-83(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    27. 27.
      "Substitution of methionine 63 or 83 in S100A9 and cysteine 42 in S100A8 abrogate the antifungal activities of S100A8/A9: potential role for oxidative regulation."
      Sroussi H.Y. , Koehler G.A. , Agabian N. , Villines D. , Palefsky J.M.
      FEMS Immunol. Med. Microbiol.55:55-61(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;MUTAGENESIS OF MET-63; MET-81 AND MET-83;INHIBITION BY ZINC IONS
    28. 28.
      "Calprotectin S100A9 calcium-binding loops I and II are essential for keratinocyte resistance to bacterial invasion."
      Champaiboon C. , Sappington K.J. , Guenther B.D. , Ross K.F. , Herzberg M.C.
      J. Biol. Chem.284:7078-7090(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;MUTAGENESIS OF GLU-36 AND GLU-78
    29. 29.
      "The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer."
      Ehrchen J.M. , Sunderkoetter C. , Foell D. , Vogl T. , Roth J.
      J. Leukoc. Biol.86:557-566(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    30. 30.
      "Identification of human S100A9 as a novel target for treatment of autoimmune disease via binding to quinoline-3-carboxamides."
      Bjoerk P. , Bjoerk A. , Vogl T. , Stenstroem M. , Liberg D. , Olsson A. , Roth J. , Ivars F. , Leanderson T.
      PLoS Biol.7:E97-E97(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;SUBUNIT;INTERACTION WITH TLR4; LY96 AND AGER;QUINOLINE-3-CARBOXAMIDE BINDING
    31. 31.
      "S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3."
      Ghavami S. , Eshragi M. , Ande S.R. , Chazin W.J. , Klonisch T. , Halayko A.J. , McNeill K.D. , Hashemi M. , Kerkhoff C. , Los M.
      Cell Res.20:314-331(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    32. 32.
      "S100 Calgranulins in inflammatory arthritis."
      Perera C. , McNeil H.P. , Geczy C.L.
      Immunol. Cell Biol.88:41-49(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    33. 33.
      "Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism."
      Simard J.C. , Girard D. , Tessier P.A.
      J. Leukoc. Biol.87:905-914(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    34. 34.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-113;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    35. 35.
      "Inflammation-associated S100 proteins: new mechanisms that regulate function."
      Goyette J. , Geczy C.L.
      Amino Acids41:821-842(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    36. 36.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    37. 37.
      "Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis."
      Simard J.C. , Simon M.M. , Tessier P.A. , Girard D.
      J. Immunol.186:3622-3631(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    38. 38.
      "S100A8 and S100A9 in cardiovascular biology and disease."
      Averill M.M. , Kerkhoff C. , Bornfeldt K.E.
      Arterioscler. Thromb. Vasc. Biol.32:223-229(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    39. 39.
      "Induction of nuclear factor-kappaB responses by the S100A9 protein is Toll-like receptor-4-dependent."
      Riva M. , Kaellberg E. , Bjoerk P. , Hancz D. , Vogl T. , Roth J. , Ivars F. , Leanderson T.
      Immunology137:172-182(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    40. 40.
      "Dynamic mobility of immunological cells expressing S100A8 and S100A9 in vivo: a variety of functional roles of the two proteins as regulators in acute inflammatory reaction."
      Koike A. , Arai S. , Yamada S. , Nagae A. , Saita N. , Itoh H. , Uemoto S. , Totani M. , Ikemoto M.
      Inflammation35:409-419(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    41. 41.
      "Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes."
      Vogl T. , Gharibyan A.L. , Morozova-Roche L.A.
      Int. J. Mol. Sci.13:2893-2917(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    42. 42.
      "S100A8 and S100A9: new insights into their roles in malignancy."
      Srikrishna G.
      J. Innate Immun.4:31-40(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    43. 43.
      "Molecular interface of S100A8 with cytochrome b and NADPH oxidase activation."
      Berthier S. , Nguyen M.V. , Baillet A. , Hograindleur M.A. , Paclet M.H. , Polack B. , Morel F.
      PLoS ONE7:E40277-E40277(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CYBA AND CYBB
    44. 44.
      "MRP14 (S100A9) protein interacts with Alzheimer beta-amyloid peptide and induces its fibrillization."
      Zhang C. , Liu Y. , Gilthorpe J. , van der Maarel J.R.
      PLoS ONE7:E32953-E32953(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APP
    45. 45.
      "Constitutive neutrophil apoptosis: regulation by cell concentration via S100 A8/9 and the MEK-ERK pathway."
      Atallah M. , Krispin A. , Trahtemberg U. , Ben-Hamron S. , Grau A. , Verbovetski I. , Mevorach D.
      PLoS ONE7:E29333-E29333(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY
    46. 46.
      "The crystal structure of human MRP14 (S100A9), a Ca(2+)-dependent regulator protein in inflammatory process."
      Itou H. , Yao M. , Fujita I. , Watanabe N. , Suzuki M. , Nishihira J. , Tanaka I.
      J. Mol. Biol.316:265-276(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEX WITH CALCIUM IONS;MASS SPECTROMETRY;SUBUNIT
    47. 47.
      "The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins."
      Korndoerfer I.P. , Brueckner F. , Skerra A.
      J. Mol. Biol.370:887-898(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 4-114 IN COMPLEX WITH S100A8;SUBUNIT;ZINC-BINDING
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