SLC6A4 ELISA Kit for Human(Homo sapiens) | EIAab.comSLC6A4 ELISA Kit for Human(Homo sapiens)

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SLC6A4 (Gene name),

Sodium-dependent serotonin transporter (Protein name ), SC6A4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

SLC6A4(HTT;SERT);

Protein name:

Sodium-dependent serotonin transporter;

Alternative:

Solute carrier family 6 member 4;5HT transporter(5HTT);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer or homooligomer (By similarity). Interacts with TGFB1I1. Interacts (via sialylated form) with MYH9. Interacts with SEC23A, SEC24C and INADL. Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake. Interacts with filamentous actin and STX1A (By similarity). Interacts (via C-terminus) with VIM. Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly. Interacts with RAB4 (GTP-bound form); the interaction retains transporter molecules intracellularly.

Function:

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

Subcellular Location:

Cell membrane Multi-pass membrane protein Endomembrane system Multi-pass membrane protein Endosome membrane Multi-pass membrane protein Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin.

Protein Attributes:

Sequence length:

630

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

630:

PGTFKERIIK | SITPETPTEI | PCGDIRLNAV |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P31645

Pfam:

PF03491

UniGene:

Hs.134662

MIM:

103780

STRING:

9606.ENSP00000261707

KEGG:

hsa:6532

SMR:

P31645

Uniprot:

P31645

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ELISA Kit for Human Sodium-dependent serotonin transporter

Cat.:

E2290r

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96T

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ELISA Kit for Human Sodium-dependent serotonin transporter

Cat.:

E2290m

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96T

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ELISA Kit for Human Sodium-dependent serotonin transporter

Cat.:

E2290h

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ELISA Kit for Human Sodium-dependent serotonin transporter

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E2290b

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96T

CLIA Kit for Human Sodium-dependent serotonin transporter

Cat.:

U2290m

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Packing:

96T

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CLIA Kit for Human Sodium-dependent serotonin transporter

Cat.:

U2290r

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Sodium-dependent serotonin transporter

Cat.:

U2290h

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MSDS:

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Packing:

96T

CLIA Kit for Human Sodium-dependent serotonin transporter

Cat.:

U2290b

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96T

Polyclonal Antibody for Human Sodium-dependent serotonin transporter

Cat.:

P2290Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Sodium-dependent serotonin transporter

Cat.:

P2290Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Sodium-dependent serotonin transporter

Cat.:

P2290Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human Sodium-dependent serotonin transporter

Protein for Human Sodium-dependent serotonin transporter

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Isolation of a cDNA encoding the human brain serotonin transporter."
Lesch K.P. , Wolozin B.L. , Estler H.C. , Murphy D.L. , Riederer P.
J. Neural Transm.91:67-73(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
2.

"Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization."
Ramamoorthy S. , Bauman A.L. , Moore K.R. , Han H. , Yang-Feng T. , Chang A.S. , Ganapathy V. , Blakely R.D.
Proc. Natl. Acad. Sci. U.S.A.90:2542-2546(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter."
Lesch K.P. , Wolozin B.L. , Murphy D.L. , Reiderer P.
J. Neurochem.60:2319-2322(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Platelet.
4.

"Molecular characterization and intracellular regulation of the human serotonin transporter in Caco-2 cells."
Iceta R. , Mesonero J.E. , Aramayona J.J. , Alcalde A.I.
J. Physiol. Pharmacol.57:119-130(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
5.

NIEHS SNPs program
Submitted (2007-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
7.

Bradley C.C. , Blakely R.D.
Submitted (1997-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-114
tissue: Placenta.
8.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-317 (ISOFORM 2)
tissue: Lung.
9.

"Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter."
Carneiro A.M.D. , Blakely R.D.
J. Biol. Chem.281:24769-24780(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFB1I1
10.

"Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2."
Mueller H.K. , Wiborg O. , Haase J.
J. Biol. Chem.281:28901-28909(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SCAMP2;SUBCELLULAR LOCATION
11.

"Plasma serotonin levels and the platelet serotonin transporter."
Brenner B. , Harney J.T. , Ahmed B.A. , Jeffus B.C. , Unal R. , Mehta J.L. , Kilic F.
J. Neurochem.102:206-215(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
12.

"Serotonin transporter phosphorylation by cGMP-dependent protein kinase is altered by a mutation associated with obsessive compulsive disorder."
Zhang Y.W. , Gesmonde J. , Ramamoorthy S. , Rudnick G.
J. Neurosci.27:10878-10886(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-276;VARIANT VAL-425
13.

"Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter."
Ahmed B.A. , Jeffus B.C. , Bukhari S.I. , Harney J.T. , Unal R. , Lupashin V.V. , van der Sluijs P. , Kilic F.
J. Biol. Chem.283:9388-9398(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RAB4;SUBCELLULAR LOCATION;INDUCTION BY SEROTONIN
14.

"The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network."
Ahmed B.A. , Bukhari I.A. , Jeffus B.C. , Harney J.T. , Thyparambil S. , Ziu E. , Fraer M. , Rusch N.J. , Zimniak P. , Lupashin V. , Tang D. , Kilic F.
PLoS ONE4:E4730-E4730(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH VIM;SUBCELLULAR LOCATION;INDUCTION BY SEROTONIN;MUTAGENESIS OF SER-611; THR-613 AND THR-616;PHOSPHORYLATION AT SER-611; THR-613 AND THR-616
15.

"Tyrosine phosphorylation of the human serotonin transporter: a role in the transporter stability and function."
Annamalai B. , Mannangatti P. , Arapulisamy O. , Shippenberg T.S. , Jayanthi L.D. , Ramamoorthy S.
Mol. Pharmacol.81:73-85(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-47 AND TYR-142
16.

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-56 AND ASN-605
17.

Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.23:373-373(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
18.

"Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype."
Ozaki N. , Goldman D. , Kaye W.H. , Plotnicov K. , Greenberg B.D. , Lappalainen J. , Rudnick G. , Murphy D.L.
Mol. Psychiatry8:933-936(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-425
19.

"A human serotonin transporter mutation causes constitutive activation of transport activity."
Kilic F. , Murphy D.L. , Rudnick G.
Mol. Pharmacol.64:440-446(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT VAL-425
20.

"Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene."
Caspi A. , Sugden K. , Moffitt T.E. , Taylor A. , Craig I.W. , Harrington H. , McClay J. , Mill J. , Martin J. , Braithwaite A. , Poulton R.
Science301:386-389(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM IN THE PROMOTER REGION
21.

"Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence."
Feinn R. , Nellissery M. , Kranzler H.R.
Am. J. Med. Genet. B Neuropsychiatr. Genet.133:79-84(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ALCOHOLISM

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