Gene name:
SIPA1L1 (E6TP1;KIAA0440) ;
Protein name:
Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) ;
Alternative:
High-risk human papilloma viruses E6 oncoproteins targeted protein 1 (E6-targeted protein 1) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with DLG4, PDLIM5, PDLIM7 and PROSAPIP1. Interacts with the actin cytoskeleton (By similarity). Interacts (via PDZ domain) with EPHA4 (via PDZ motif); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases. Interacts with HPV E6.
Function:
Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis.
Subcellular Location:
Cytoplasm
cytoskeleton
Cell junction
synapse
postsynaptic cell membrane
postsynaptic density
Cell junction
synapse
synaptosome
Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons.
Protein Attributes:
50:
MTSLKRSQTE | RPLATDRASV | VGTDGTPKVH | TDDFYMRRFR | SQNGSLGSSV |
100:
MAPVGPPRSE | GSHHITSTPG | VPKMGVRARI | ADWPPRKENI | KESSRSSQEI |
150:
ETSSCLDSLS | SKSSPVSQGS | SVSLNSNDSA | MLKSIQNTLK | NKTRPSENMD |
200:
SRFLMPEAYP | SSPRKALRRI | RQRSNSDITI | SELDVDSFDE | CISPTYKTGP |
250:
SLHREYGSTS | SIDKQGTSGE | SFFDLLKGYK | DDKSDRGPTP | TKLSDFLITG |
300:
GGKGSGFSLD | VIDGPISQRE | NLRLFKEREK | PLKRRSKSET | GDSSIFRKLR |
350:
NAKGEELGKS | SDLEDNRSED | SVRPWTCPKC | FAHYDVQSIL | FDLNEAIMNR |
400:
HNVIKRRNTT | TGASAAAVAS | LVSGPLSHSA | SFSSPMGSTE | DLNSKGSLSM |
450:
DQGDDKSNEL | VMSCPYFRNE | IGGEGERKIS | LSKSNSGSFS | GCESASFEST |
500:
LSSHCTNAGV | AVLEVPKENL | VLHLDRVKRY | IVEHVDLGAY | YYRKFFYQKE |
550:
HWNYFGADEN | LGPVAVSIRR | EKPDEMKENG | SPYNYRIIFR | TSELMTLRGS |
600:
VLEDAIPSTA | KHSTARGLPL | KEVLEHVVPE | LNVQCLRLAF | NTPKVTEQLM |
650:
KLDEQGLNYQ | QKVGIMYCKA | GQSTEEEMYN | NESAGPAFEE | FLQLLGERVR |
700:
LKGFEKYRAQ | LDTKTDSTGT | HSLYTTYKDY | EIMFHVSTML | PYTPNNKQQL |
750:
LRKRHIGNDI | VTIVFQEPGA | QPFSPKNIRS | HFQHVFVIVR | VHNPCSDSVC |
800:
YSVAVTRSRD | VPSFGPPIPK | GVTFPKSNVF | RDFLLAKVIN | AENAAHKSEK |
850:
FRAMATRTRQ | EYLKDLAEKN | VTNTPIDPSG | KFPFISLASK | KKEKSKPYPG |
900:
AELSSMGAIV | WAVRAEDYNK | AMELDCLLGI | SNEFIVLIEQ | ETKSVVFNCS |
950:
CRDVIGWTST | DTSLKIFYER | GECVSVGSFI | NIEEIKEIVK | RLQFVSKGCE |
1000:
SVEMTLRRNG | LGQLGFHVNY | EGIVADVEPY | GYAWQAGLRQ | GSRLVEICKV |
1050:
AVATLSHEQM | IDLLRTSVTV | KVVIIPPHDD | CTPRRSCSET | YRMPVMEYKM |
1100:
NEGVSYEFKF | PFRNNNKWQR | NASKGPHSPQ | VPSQVQSPMT | SRLNAGKGDG |
1150:
KMPPPERAAN | IPRSISSDGR | PLERRLSPGS | DIYVTVSSMA | LARSQCRNSP |
1200:
SNLSSSSDTG | SVGGTYRQKS | MPEGFGVSRR | SPASIDRQNT | QSDIGGSGKS |
1250:
TPSWQRSEDS | IADQMAYSYR | GPQDFNSFVL | EQHEYTEPTC | HLPAVSKVLP |
1300:
AFRESPSGRL | MRQDPVVHLS | PNKQGHSDSH | YSSHSSSNTL | SSNASSAHSD |
1350:
EKWYDGDRTE | SELNSYNYLQ | GTSADSGIDT | TSYGPSHGST | ASLGAATSSP |
1400:
RSGPGKEKVA | PLWHSSSEVI | SMADRTLETE | SHGLDRKTES | SLSLDIHSKS |
1450:
QAGSTPLTRE | NSTFSINDAA | SHTSTMSSRH | SASPVVFTSA | RSSPKEELHP |
1500:
AAPSQLAPSF | SSSSSSSSGP | RSFYPRQGAT | SKYLIGWKKP | EGTINSVGFM |
1550:
DTRKRHQSDG | NEIAHTRLRA | STRDLRASPK | PTSKSTIEED | LKKLIDLESP |
1600:
TPESQKSFKF | HALSSPQSPF | PSTPTSRRAL | HRTLSDESIY | NSQREHFFTS |
1650:
RASLLDQALP | NDVLFSSTYP | SLPKSLPLRR | PSYTLGMKSL | HGEFSASDSS |
1700:
LTDIQETRRQ | PMPDPGLMPL | PDTAADLDWS | NLVDAAKAYE | VQRASFFAAS |
1750:
DENHRPLSAA | SNSDQLEDQA | LAQMKPYSSS | KDSSPTLASK | VDQLEGMLKM |
1800:
LREDLKKEKE | DKAHLQAEVQ | HLREDNLRLQ | EESQNASDKL | KKFTEWVFNT |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Human SIPA1-like protein 1
ELISA Kit for Human SIPA1-like protein 1
ELISA Kit for Human SIPA1-like protein 1
CLIA Kit for Human SIPA1-like protein 1
CLIA Kit for Human SIPA1-like protein 1
CLIA Kit for Human SIPA1-like protein 1
Polyclonal Antibody for Human SIPA1-like protein 1
Polyclonal Antibody for Human SIPA1-like protein 1
Polyclonal Antibody for Human SIPA1-like protein 1
Monoclonal Antibody for Human SIPA1-like protein 1
Monoclonal Antibody for Human SIPA1-like protein 1
Monoclonal Antibody for Human SIPA1-like protein 1
Protein for Human SIPA1-like protein 1
Protein for Human SIPA1-like protein 1
Protein for Human SIPA1-like protein 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1255; SER-1270; SER-1433; SER-1549; THR-1551; SER-1554; SER-1565 AND SER-1568;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT [LARGE SCALE ANALYSIS] ASP-996