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Index > Protein center > SIPA1L1(Gene name) > Human
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  • SIPA1L1 (Gene name),
  • Signal-induced proliferation-associated 1-like protein 1 (Protein name ),  SI1L1_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    SIPA1L1(E6TP1;KIAA0440);
    Protein name:
    Signal-induced proliferation-associated 1-like protein 1(SIPA1-like protein 1);
    Alternative:
    High-risk human papilloma viruses E6 oncoproteins targeted protein 1(E6-targeted protein 1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with DLG4, PDLIM5, PDLIM7 and PROSAPIP1. Interacts with the actin cytoskeleton (By similarity). Interacts (via PDZ domain) with EPHA4 (via PDZ motif); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases. Interacts with HPV E6.
    Function:
    Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis.
    Subcellular Location:
    Cytoplasm cytoskeleton Cell junction synapse postsynaptic cell membrane postsynaptic density Cell junction synapse synaptosome Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons.
    Protein Attributes:
    Sequence length:
    1804
    Sequence:
    50:
    MTSLKRSQTE | RPLATDRASV | VGTDGTPKVH | TDDFYMRRFR | SQNGSLGSSV | 
    100:
    MAPVGPPRSE | GSHHITSTPG | VPKMGVRARI | ADWPPRKENI | KESSRSSQEI | 
    150:
    ETSSCLDSLS | SKSSPVSQGS | SVSLNSNDSA | MLKSIQNTLK | NKTRPSENMD | 
    200:
    SRFLMPEAYP | SSPRKALRRI | RQRSNSDITI | SELDVDSFDE | CISPTYKTGP | 
    250:
    SLHREYGSTS | SIDKQGTSGE | SFFDLLKGYK | DDKSDRGPTP | TKLSDFLITG | 
    300:
    GGKGSGFSLD | VIDGPISQRE | NLRLFKEREK | PLKRRSKSET | GDSSIFRKLR | 
    350:
    NAKGEELGKS | SDLEDNRSED | SVRPWTCPKC | FAHYDVQSIL | FDLNEAIMNR | 
    400:
    HNVIKRRNTT | TGASAAAVAS | LVSGPLSHSA | SFSSPMGSTE | DLNSKGSLSM | 
    450:
    DQGDDKSNEL | VMSCPYFRNE | IGGEGERKIS | LSKSNSGSFS | GCESASFEST | 
    500:
    LSSHCTNAGV | AVLEVPKENL | VLHLDRVKRY | IVEHVDLGAY | YYRKFFYQKE | 
    550:
    HWNYFGADEN | LGPVAVSIRR | EKPDEMKENG | SPYNYRIIFR | TSELMTLRGS | 
    600:
    VLEDAIPSTA | KHSTARGLPL | KEVLEHVVPE | LNVQCLRLAF | NTPKVTEQLM | 
    650:
    KLDEQGLNYQ | QKVGIMYCKA | GQSTEEEMYN | NESAGPAFEE | FLQLLGERVR | 
    700:
    LKGFEKYRAQ | LDTKTDSTGT | HSLYTTYKDY | EIMFHVSTML | PYTPNNKQQL | 
    750:
    LRKRHIGNDI | VTIVFQEPGA | QPFSPKNIRS | HFQHVFVIVR | VHNPCSDSVC | 
    800:
    YSVAVTRSRD | VPSFGPPIPK | GVTFPKSNVF | RDFLLAKVIN | AENAAHKSEK | 
    850:
    FRAMATRTRQ | EYLKDLAEKN | VTNTPIDPSG | KFPFISLASK | KKEKSKPYPG | 
    900:
    AELSSMGAIV | WAVRAEDYNK | AMELDCLLGI | SNEFIVLIEQ | ETKSVVFNCS | 
    950:
    CRDVIGWTST | DTSLKIFYER | GECVSVGSFI | NIEEIKEIVK | RLQFVSKGCE | 
    1000:
    SVEMTLRRNG | LGQLGFHVNY | EGIVADVEPY | GYAWQAGLRQ | GSRLVEICKV | 
    1050:
    AVATLSHEQM | IDLLRTSVTV | KVVIIPPHDD | CTPRRSCSET | YRMPVMEYKM | 
    1100:
    NEGVSYEFKF | PFRNNNKWQR | NASKGPHSPQ | VPSQVQSPMT | SRLNAGKGDG | 
    1150:
    KMPPPERAAN | IPRSISSDGR | PLERRLSPGS | DIYVTVSSMA | LARSQCRNSP | 
    1200:
    SNLSSSSDTG | SVGGTYRQKS | MPEGFGVSRR | SPASIDRQNT | QSDIGGSGKS | 
    1250:
    TPSWQRSEDS | IADQMAYSYR | GPQDFNSFVL | EQHEYTEPTC | HLPAVSKVLP | 
    1300:
    AFRESPSGRL | MRQDPVVHLS | PNKQGHSDSH | YSSHSSSNTL | SSNASSAHSD | 
    1350:
    EKWYDGDRTE | SELNSYNYLQ | GTSADSGIDT | TSYGPSHGST | ASLGAATSSP | 
    1400:
    RSGPGKEKVA | PLWHSSSEVI | SMADRTLETE | SHGLDRKTES | SLSLDIHSKS | 
    1450:
    QAGSTPLTRE | NSTFSINDAA | SHTSTMSSRH | SASPVVFTSA | RSSPKEELHP | 
    1500:
    AAPSQLAPSF | SSSSSSSSGP | RSFYPRQGAT | SKYLIGWKKP | EGTINSVGFM | 
    1550:
    DTRKRHQSDG | NEIAHTRLRA | STRDLRASPK | PTSKSTIEED | LKKLIDLESP | 
    1600:
    TPESQKSFKF | HALSSPQSPF | PSTPTSRRAL | HRTLSDESIY | NSQREHFFTS | 
    1650:
    RASLLDQALP | NDVLFSSTYP | SLPKSLPLRR | PSYTLGMKSL | HGEFSASDSS | 
    1700:
    LTDIQETRRQ | PMPDPGLMPL | PDTAADLDWS | NLVDAAKAYE | VQRASFFAAS | 
    1750:
    DENHRPLSAA | SNSDQLEDQA | LAQMKPYSSS | KDSSPTLASK | VDQLEGMLKM | 
    1800:
    LREDLKKEKE | DKAHLQAEVQ | HLREDNLRLQ | EESQNASDKL | KKFTEWVFNT | 
    1804:
    IDMS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    UniGene:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human SIPA1-like protein 1
    Cat.:
    E6550m
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    Packing:
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    E6550r
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    96T
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    ELISA Kit for Human SIPA1-like protein 1
    Cat.:
    E6550h
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    96T
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    CLIA Kit for Human SIPA1-like protein 1
    Cat.:
    U6550m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SIPA1-like protein 1
    Cat.:
    U6550h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human SIPA1-like protein 1
    Cat.:
    U6550r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human SIPA1-like protein 1
    Cat.:
    P6550Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SIPA1-like protein 1
    Cat.:
    P6550Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SIPA1-like protein 1
    Monoclonal Antibody for Human SIPA1-like protein 1
    Monoclonal Antibody for Human SIPA1-like protein 1
    Monoclonal Antibody for Human SIPA1-like protein 1
    Protein for Human SIPA1-like protein 1
    Protein for Human SIPA1-like protein 1
    Protein for Human SIPA1-like protein 1

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    References
    1. 1.
      "The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation."
      Gao Q. , Srinivasan S. , Boyer S.N. , Wazer D.E. , Band V.
      Mol. Cell. Biol.19:733-744(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY;INTERACTION WITH HPV E6
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."
      Ishikawa K. , Nagase T. , Nakajima D. , Seki N. , Ohira M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    3. 3.
      "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
      DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
    5. 5.
      "The DNA sequence and analysis of human chromosome 14."
      Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
      Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    7. 7.
      "The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases."
      Richter M. , Murai K.K. , Bourgin C. , Pak D.T. , Pasquale E.B.
      J. Neurosci.27:14205-14215(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPHA4
    8. 8.
      "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
      J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1270;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1585;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162; SER-288; SER-1549 AND SER-1585;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    13. 13.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1255; SER-1270; SER-1433; SER-1549; THR-1551; SER-1554; SER-1565 AND SER-1568;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1181; SER-1270; SER-1431; SER-1433; SER-1549; SER-1585 AND SER-1734;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-996
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