SIK1 ELISA Kit for Human(Homo sapiens) | EIAab.comSIK1 ELISA Kit for Human(Homo sapiens)

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SIK1 (Gene name),

Serine/threonine-protein kinase SIK1 (Protein name ), SIK1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SIK1(SIK;SNF1LK);

Protein name:

Serine/threonine-protein kinase SIK1;

Alternative:

Serine/threonine-protein kinase SNF1-like kinase 1(Serine/threonine-protein kinase SNF1LK);Salt-inducible protein kinase 1(SIK-1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with ATP1A1 (By similarity). Interacts (when phosphorylated on Thr-182 and Ser-186) with YWHAZ.

Function:

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, TORC1/CRTC1 and TORC2/CRTC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators TORC1/CRTC1 and TORC2/CRTC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1.

Subcellular Location:

Cytoplasm Nucleus Following ACTH (adrenocorticotropic hormone) treatment and subsequent phosphorylation by PKA, translocates to the cytoplasm, where it binds to YWHAZ.

Protein Attributes:

Sequence length:

783

Sequence:

50:

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783:

RLAPGCEPLG | LLQGDCEMED | LMPCSLGTFV | LVQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P57059

STRING:

9606.ENSP00000270162

MIM:

605705

UniGene:

Hs.282113

String:

P57059

Pfam:

PF00069

KEGG:

hsa:150094

Uniprot:

P57059

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ELISA Kit for Human Serine/threonine-protein kinase SIK1

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ELISA Kit for Human Serine/threonine-protein kinase SIK1

Cat.:

E14381h

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Manual:

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96T

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ELISA Kit for Human Serine/threonine-protein kinase SIK1

Cat.:

E14381m

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Packing:

96T

CLIA Kit for Human Serine/threonine-protein kinase SIK1

Cat.:

U14381h

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Manual:

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Packing:

96T

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CLIA Kit for Human Serine/threonine-protein kinase SIK1

MSDS:

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CLIA Kit for Human Serine/threonine-protein kinase SIK1

Cat.:

U14381m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Serine/threonine-protein kinase SIK1

Monoclonal Antibody for Human Serine/threonine-protein kinase SIK1

Protein for Human Serine/threonine-protein kinase SIK1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1."
Lizcano J.M. , Goeransson O. , Toth R. , Deak M. , Morrice N.A. , Boudeau J. , Hawley S.A. , Udd L. , Maekelae T.P. , Hardie D.G. , Alessi D.R.
EMBO J.23:833-843(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;ENZYME REGULATION;PHOSPHORYLATION AT THR-182;MUTAGENESIS OF THR-182
2.

Shimizu N. , Kudoh J. , Shibuya K.
Submitted (2000-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Fetal lung.
3.

"The DNA sequence of human chromosome 21."
Hattori M. , Fujiyama A. , Taylor T.D. , Watanabe H. , Yada T. , Park H.-S. , Toyoda A. , Ishii K. , Totoki Y. , Choi D.-K. , Groner Y. , Soeda E. , Ohki M. , Takagi T. , Sakaki Y. , Taudien S. , Blechschmidt K. , Polley A. , more...
Nature405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT VAL-615
tissue: Testis.
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-783;VARIANT VAL-615
tissue: Spleen.
6.

"14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK."
Al-Hakim A.K. , Goransson O. , Deak M. , Toth R. , Campbell D.G. , Morrice N.A. , Prescott A.R. , Alessi D.R.
J. Cell Sci.118:5661-5673(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH YWHAZ
7.

"Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity."
Hashimoto Y.K. , Satoh T. , Okamoto M. , Takemori H.
J. Cell. Biochem.104:1724-1739(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;AUTOPHOSPHORYLATION;PHOSPHORYLATION AT THR-182 AND SER-186;INTERACTION WITH YWHAZ;MUTAGENESIS OF LYS-56; SER-135; SER-186; SER-209 AND SER-248
8.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
9.

"SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis."
Cheng H. , Liu P. , Wang Z.C. , Zou L. , Santiago S. , Garbitt V. , Gjoerup O.V. , Iglehart J.D. , Miron A. , Richardson A.L. , Hahn W.C. , Zhao J.J.
Sci. Signal.2:RA35-RA35(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF LYS-56
10.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-15; ASN-142; SER-211; ASP-469; VAL-615; LEU-696 AND VAL-725

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