Gene name:
SIRT6 (SIR2L6) ;
Protein name:
NAD-dependent deacetylase sirtuin-6 ;
Alternative:
SIR2-like protein 6 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with RELA.
Function:
NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein.
Subcellular Location:
Nucleus
nucleoplasm
Predominantly nuclear. Associated with telomeric heterochromatin regions.
Protein Attributes:
50:
MSVNYAAGLS | PYADKGKCGL | PEIFDPPEEL | ERKVWELARL | VWQSSSVVFH |
100:
TGAGISTASG | IPDFRGPHGV | WTMEERGLAP | KFDTTFESAR | PTQTHMALVQ |
150:
LERVGLLRFL | VSQNVDGLHV | RSGFPRDKLA | ELHGNMFVEE | CAKCKTQYVR |
200:
DTVVGTMGLK | ATGRLCTVAK | ARGLRACRGE | LRDTILDWED | SLPDRDLALA |
250:
DEASRNADLS | ITLGTSLQIR | PSGNLPLATK | RRGGRLVIVN | LQPTKHDRHA |
300:
DLRIHGYVDE | VMTRLMKHLG | LEIPAWDGPR | VLERALPPLP | RPPTPKLEPK |
350:
EESPTRINGS | IPAGPKQEPC | AQHNGSEPAS | PKRERPTSPA | PHRPPKRVKA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Human
Mouse
ELISA Kit for Human NAD-dependent deacetylase sirtuin-6
ELISA Kit for Human NAD-dependent deacetylase sirtuin-6
ELISA Kit for Human NAD-dependent deacetylase sirtuin-6
ELISA Kit for Human NAD-dependent deacetylase sirtuin-6
CLIA Kit for Human NAD-dependent deacetylase sirtuin-6
CLIA Kit for Human NAD-dependent deacetylase sirtuin-6
CLIA Kit for Human NAD-dependent deacetylase sirtuin-6
CLIA Kit for Human NAD-dependent deacetylase sirtuin-6
Polyclonal Antibody for Human NAD-dependent deacetylase sirtuin-6
Polyclonal Antibody for Human NAD-dependent deacetylase sirtuin-6
Polyclonal Antibody for Human NAD-dependent deacetylase sirtuin-6
Polyclonal Antibody for Human NAD-dependent deacetylase sirtuin-6
Monoclonal Antibody for Human NAD-dependent deacetylase sirtuin-6
Monoclonal Antibody for Human NAD-dependent deacetylase sirtuin-6
Monoclonal Antibody for Human NAD-dependent deacetylase sirtuin-6
Monoclonal Antibody for Human NAD-dependent deacetylase sirtuin-6
Protein for Human NAD-dependent deacetylase sirtuin-6
Protein for Human NAD-dependent deacetylase sirtuin-6
Protein for Human NAD-dependent deacetylase sirtuin-6
Protein for Human NAD-dependent deacetylase sirtuin-6
R&D Technical Data
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Precision
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Recovery
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Linearity
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