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Index > Protein center > SIRT6(Gene name) > Human
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  • SIRT6 (Gene name),
  • NAD-dependent deacetylase sirtuin-6 (Protein name ),  SIRT6_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    SIRT6(SIR2L6);
    Protein name:
    NAD-dependent deacetylase sirtuin-6;
    Alternative:
    SIR2-like protein 6;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with RELA.
    Function:
    NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein.
    Subcellular Location:
    Nucleus nucleoplasm Predominantly nuclear. Associated with telomeric heterochromatin regions.
    Protein Attributes:
    Sequence length:
    355
    Sequence:
    50:
    MSVNYAAGLS | PYADKGKCGL | PEIFDPPEEL | ERKVWELARL | VWQSSSVVFH | 
    100:
    TGAGISTASG | IPDFRGPHGV | WTMEERGLAP | KFDTTFESAR | PTQTHMALVQ | 
    150:
    LERVGLLRFL | VSQNVDGLHV | RSGFPRDKLA | ELHGNMFVEE | CAKCKTQYVR | 
    200:
    DTVVGTMGLK | ATGRLCTVAK | ARGLRACRGE | LRDTILDWED | SLPDRDLALA | 
    250:
    DEASRNADLS | ITLGTSLQIR | PSGNLPLATK | RRGGRLVIVN | LQPTKHDRHA | 
    300:
    DLRIHGYVDE | VMTRLMKHLG | LEIPAWDGPR | VLERALPPLP | RPPTPKLEPK | 
    350:
    EESPTRINGS | IPAGPKQEPC | AQHNGSEPAS | PKRERPTSPA | PHRPPKRVKA | 
    355:
    KAVPS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    String:
    KEGG:
    UniGene:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human NAD-dependent deacetylase sirtuin-6
    Cat.:
    E2127h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human NAD-dependent deacetylase sirtuin-6
    Cat.:
    E2127m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human NAD-dependent deacetylase sirtuin-6
    Cat.:
    E2127h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human NAD-dependent deacetylase sirtuin-6
    Cat.:
    E2127m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NAD-dependent deacetylase sirtuin-6
    Cat.:
    U2127m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NAD-dependent deacetylase sirtuin-6
    Cat.:
    U2127h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human NAD-dependent deacetylase sirtuin-6
    Cat.:
    U2127m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NAD-dependent deacetylase sirtuin-6
    Cat.:
    U2127h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human NAD-dependent deacetylase sirtuin-6
    Cat.:
    P2127Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NAD-dependent deacetylase sirtuin-6
    Cat.:
    P2127Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NAD-dependent deacetylase sirtuin-6
    Cat.:
    P2127Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NAD-dependent deacetylase sirtuin-6
    Cat.:
    P2127Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human NAD-dependent deacetylase sirtuin-6
    Monoclonal Antibody for Human NAD-dependent deacetylase sirtuin-6
    Monoclonal Antibody for Human NAD-dependent deacetylase sirtuin-6
    Monoclonal Antibody for Human NAD-dependent deacetylase sirtuin-6
    Protein for Human NAD-dependent deacetylase sirtuin-6
    Protein for Human NAD-dependent deacetylase sirtuin-6
    Protein for Human NAD-dependent deacetylase sirtuin-6
    Protein for Human NAD-dependent deacetylase sirtuin-6

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