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Index > Protein center > SMAD3(Gene name) > Human
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  • SMAD3 (Gene name),
  • Mothers against decapentaplegic homolog 3 (Protein name ),  SMAD3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    SMAD3(MADH3);
    Protein name:
    Mothers against decapentaplegic homolog 3(MAD homolog 3;Mad3;Mothers against DPP homolog 3;hMAD-3);
    Alternative:
    SMAD family member 3(SMAD 3;Smad3;hSMAD3);JV15-2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer; in the absence of TGF-beta. Homooligomer; in the presence of TGF-beta. Heterotrimer; forms a heterotrimer in the presence of TGF-beta consisting of two molecules of C-terminally phosphorylated SMAD2 or SMAD3 and one of SMAD4 to form the transcriptionally active SMAD2/SMAD3-SMAD4 complex. Interacts with TGFBR1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3. Interacts with AIP1, TGFB1I1, TTRAP, FOXL2, PML, PRDM16, HGS and WWP1. Interacts (via MH2 domain) with CITED2 (via C-terminus) (By similarity). Interacts with NEDD4L; the interaction requires TGF-beta stimulation (By similarity). Interacts (via the MH2 domain) with ZFYVE9. Interacts with HDAC1, VDR, TGIF and TGIF2, RUNX3, CREBBP, SKOR1, SKOR2, SNON, ATF2, SMURF2 and TGFB1I1. Interacts with DACH1; the interaction inhibits the TGF-beta signaling. Forms a complex with SMAD2 and TRIM33 upon addition of TGF-beta. Found in a complex with SMAD3, RAN and XPO4. Interacts in the complex directly with XPO4. Interacts (via the MH2 domain) with LEMD3; the interaction represses SMAD3 transcriptional activity through preventing the formation of the heteromeric complex with SMAD4 and translocation to the nucleus. Interacts with RBPMS. Interacts (via MH2 domain) with MECOM. Interacts with WWTR1 (via its coiled-coil domain). Interacts (via the linker region) with EP300 (C-terminal); the interaction promotes SMAD3 acetylation and is enhanced by TGF-beta phosphorylation in the C-terminal of SMAD3. This interaction can be blocked by competitive binding of adenovirus oncoprotein E1A to the same C-terminal site on EP300, which then results in partially inhibited SMAD3/SMAD4 transcriptional activity. Interacts with SKI; the interaction represses SMAD3 transcriptional activity. Component of the multimeric complex SMAD3/SMAD4/JUN/FOS which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. Interacts (via an N-terminal domain) with JUN (via its basic DNA binding and leucine zipper domains); this interaction is essential for DNA binding and cooperative transcriptional activity in response to TGF-beta. Interacts with PPM1A; the interaction dephosphorylates SMAD3 in the C-terminal SXS motif leading to disruption of the SMAD2/3-SMAD4 complex, nuclear export and termination of TGF-beta signaling. Interacts (dephosphorylated form via the MH1 and MH2 domains) with RANBP3 (via its C-terminal R domain); the interaction results in the export of dephosphorylated SMAD3 out of the nucleus and termination of the TGF-beta signaling. Interacts with MEN1. Interacts with IL1F7.
    Function:
    Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures.
    Subcellular Location:
    Cytoplasm Nucleus Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1. Co-localizes with LEMD3 at the nucleus inner membrane. MAPK-mediated phosphorylation appears to have no effect on nuclear import.
    Protein Attributes:
    Sequence length:
    425
    Sequence:
    50:
    MSSILPFTPP | IVKRLLGWKK | GEQNGQEEKW | CEKAVKSLVK | KLKKTGQLDE | 
    100:
    LEKAITTQNV | NTKCITIPRS | LDGRLQVSHR | KGLPHVIYCR | LWRWPDLHSH | 
    150:
    HELRAMELCE | FAFNMKKDEV | CVNPYHYQRV | ETPVLPPVLV | PRHTEIPAEF | 
    200:
    PPLDDYSHSI | PENTNFPAGI | EPQSNIPETP | PPGYLSEDGE | TSDHQMNHSM | 
    250:
    DAGSPNLSPN | PMSPAHNNLD | LQPVTYCEPA | FWCSISYYEL | NQRVGETFHA | 
    300:
    SQPSMTVDGF | TDPSNSERFC | LGLLSNVNRN | AAVELTRRHI | GRGVRLYYIG | 
    350:
    GEVFAECLSD | SAIFVQSPNC | NQRYGWHPAT | VCKIPPGCNL | KIFNNQEFAA | 
    400:
    LLAQSVNQGF | EAVYQLTRMC | TIRMSFVKGW | GAEYRRQTVT | STPCWIELHL | 
    425:
    NGPLQWLDKV | LTQMGSPSIR | CSSVS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    KEGG:
    SMR:
    MIM:
    Pfam:
    UniGene:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human MAD homolog 3
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    ELISA Kit for Human MAD homolog 3
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    ELISA Kit for Human MAD homolog 3
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    ELISA Kit for Human MAD homolog 3
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    ELISA Kit for Human MAD homolog 3
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    CLIA Kit for Human MAD homolog 3
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    CLIA Kit for Human MAD homolog 3
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    U2185c
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    CLIA Kit for Human MAD homolog 3
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    U2185h
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    CLIA Kit for Human MAD homolog 3
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    CLIA Kit for Human MAD homolog 3
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    Polyclonal Antibody for Human MAD homolog 3
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    Polyclonal Antibody for Human MAD homolog 3
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    Polyclonal Antibody for Human MAD homolog 3
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    P2185Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MAD homolog 3
    Polyclonal Antibody for Human MAD homolog 3
    Monoclonal Antibody for Human MAD homolog 3
    Monoclonal Antibody for Human MAD homolog 3
    Monoclonal Antibody for Human MAD homolog 3
    Monoclonal Antibody for Human MAD homolog 3
    Monoclonal Antibody for Human MAD homolog 3
    Protein for Human MAD homolog 3
    Protein for Human MAD homolog 3
    Protein for Human MAD homolog 3
    Protein for Human MAD homolog 3
    Protein for Human MAD homolog 3

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    References
    1. 1.
      "Receptor-associated Mad homologues synergize as effectors of the TGF-beta response."
      Zhang Y. , Feng X.-H. , Wu R.-Y. , Derynck R.
      Nature383:168-172(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PHOSPHORYLATION
      tissue: Placenta.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers."
      Arai T. , Akiyama Y. , Okabe S. , Ando M. , Endo M. , Yuasa Y.
      Cancer Lett.122:157-163(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Colon carcinoma.
    4. 4.
      Hagiwara K. , Yang K. , McMenamin M.G. , Freeman A.H. , Bennett W.P. , Nagashima M. , Minter A.R. , Miyazono K. , Takenoshita S. , Harris C.C.
      Submitted (1997-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4)
      tissue: Brain.
    6. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Pancreas.
    8. 9.
      "TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4."
      Nakao A. , Imamura T. , Souchelnytskyi S. , Kawabata M. , Ishisaki A. , Oeda E. , Tamaki K. , Hanai J. , Heldin C.H. , Miyazono K. , ten Dijke P.
      EMBO J.16:5353-5362(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFBR1
    9. 10.
      "SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor."
      Tsukazaki T. , Chiang T.A. , Davison A.F. , Attisano L. , Wrana J.L.
      Cell95:779-791(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZFYVE9
    10. 11.
      "Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors."
      Kawabata M. , Inoue H. , Hanyu A. , Imamura T. , Miyazono K.
      EMBO J.17:4056-4065(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    11. 12.
      "TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein."
      Shen X. , Hu P.P. , Liberati N.T. , Datto M.B. , Frederick J.P. , Wang X.F.
      Mol. Biol. Cell9:3309-3319(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;INTERACTION WITH EP300
    12. 13.
      "The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3."
      Kurokawa M. , Mitani K. , Irie K. , Matsuyama T. , Takahashi T. , Chiba S. , Yazaki Y. , Matsumoto K. , Hirai H.
      Nature394:92-96(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MECOM
    13. 14.
      "Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription."
      Zhang Y. , Feng X.H. , Derynck R.
      Nature394:909-913(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION AS A COMPONENT OF THE SMAD3/SMAD4/JUN/FOS COMPLEX;INTERACTION WITH JUN AND FOS;DNA-BINDING;FUNCTION
    14. 15.
      "Roles of pathway-specific and inhibitory Smads in activin receptor signaling."
      Lebrun J.J. , Takabe K. , Chen Y. , Vale W.
      Mol. Endocrinol.13:15-23(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ACVR1B;FUNCTION
    15. 16.
      "Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity."
      Qing J. , Zhang Y. , Derynck R.
      J. Biol. Chem.275:38802-38812(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JUN IN THE SMAD3/SMAD4/JUN/FOS COMPLEX;DNA-BINDING;FUNCTION;MUTAGENESIS OF LYS-40; LYS-41; LYS-43; LYS-44 AND ARG-74
    16. 17.
      "The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway."
      Hocevar B.A. , Smine A. , Xu X.X. , Howe P.H.
      EMBO J.20:2789-2801(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB2
    17. 18.
      "Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription."
      Leong G.M. , Subramaniam N. , Figueroa J. , Flanagan J.L. , Hayman M.J. , Eisman J.A. , Kouzmenko A.P.
      J. Biol. Chem.276:18243-18248(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNW1
    18. 19.
      "TGIF2 interacts with histone deacetylase 1 and represses transcription."
      Melhuish T.A. , Gallo C.M. , Wotton D.
      J. Biol. Chem.276:32109-32114(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGIF2
    19. 20.
      "The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization."
      Chacko B.M. , Qin B. , Correia J.J. , Lam S.S. , de Caestecker M.P. , Lin K.
      Nat. Struct. Biol.8:248-253(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;PHOSPHORYLATION;MUTAGENESIS OF 422-SER--SER-425
    20. 21.
      "Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling."
      Kaji H. , Canaff L. , Lebrun J.J. , Goltzman D. , Hendy G.N.
      Proc. Natl. Acad. Sci. U.S.A.98:3837-3842(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MEN1
    21. 22.
      "DACH1 inhibits transforming growth factor-beta signaling through binding Smad4."
      Wu K. , Yang Y. , Wang C. , Davoli M.A. , D'Amico M. , Li A. , Cveklova K. , Kozmik Z. , Lisanti M.P. , Russell R.G. , Cvekl A. , Pestell R.G.
      J. Biol. Chem.278:51673-51684(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DACH1
    22. 23.
      "Cyclin-dependent kinases regulate the antiproliferative function of Smads."
      Matsuura I. , Denissova N.G. , Wang G. , He D. , Long J. , Liu F.
      Nature430:226-231(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-8; THR-179; SER-204; SER-208 AND SER-213;FUNCTION;MUTAGENESIS OF THR-8; THR-179; SER-204; SER-208 AND SER-213
    23. 24.
      "The Smad3 linker region contains a transcriptional activation domain."
      Wang G. , Long J. , Matsuura I. , He D. , Liu F.
      Biochem. J.386:29-34(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TRANSCRIPTIONAL ACTIVATION DOMAIN;FUNCTION;PHOSPHORYLATION;SUBUNIT;INTERACTION WITH EP300
    24. 25.
      "Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3."
      Matsuura I. , Wang G. , He D. , Liu F.
      Biochemistry44:12546-12553(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-179; SER-204 AND SER-208;SUBCELLULAR LOCATION;FUNCTION;MUTAGENESIS OF THR-179; SER-204 AND SER-208
    25. 26.
      "MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling."
      Lin F. , Morrison J.M. , Wu W. , Worman H.J.
      Hum. Mol. Genet.14:437-445(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH LEMD3
    26. 27.
      "Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling."
      Wang H. , Song K. , Sponseller T.L. , Danielpour D.
      J. Biol. Chem.280:5154-5162(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFB1I1
    27. 28.
      "The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines."
      Pan D. , Estevez-Salmeron L.D. , Stroschein S.L. , Zhu X. , He J. , Zhou S. , Luo K.
      J. Biol. Chem.280:15992-16001(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LEMD3
    28. 29.
      "Nuclear targeting of transforming growth factor-beta-activated Smad complexes."
      Chen H.B. , Rud J.G. , Lin K. , Xu L.
      J. Biol. Chem.280:21329-21336(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;SUBCELLULAR LOCATION
    29. 30.
      "Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues."
      Arndt S. , Poser I. , Schubert T. , Moser M. , Bosserhoff A.-K.
      Lab. Invest.85:1330-1341(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SKOR2
    30. 31.
      "Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP."
      Nitta E. , Izutsu K. , Yamaguchi Y. , Imai Y. , Ogawa S. , Chiba S. , Kurokawa M. , Hirai H.
      Oncogene24:6165-6173(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MECOM
    31. 32.
      "PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling."
      Lin X. , Duan X. , Liang Y.Y. , Su Y. , Wrighton K.H. , Long J. , Hu M. , Davis C.M. , Wang J. , Brunicardi F.C. , Shi Y. , Chen Y.G. , Meng A. , Feng X.H.
      Cell125:915-928(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPM1A;DEPHOSPHORYLATION;FUNCTION;SUBCELLULAR LOCATION
    32. 33.
      "Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway."
      He W. , Dorn D.C. , Erdjument-Bromage H. , Tempst P. , Moore M.A. , Massague J.
      Cell125:929-941(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH SMAD2 AND TRIM33;INTERACTION WITH SMAD2 AND TRIM33
    33. 34.
      "The mechanism of nuclear export of Smad3 involves exportin 4 and Ran."
      Kurisaki A. , Kurisaki K. , Kowanetz M. , Sugino H. , Yoneda Y. , Heldin C.-H. , Moustakas A.
      Mol. Cell. Biol.26:1318-1332(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH RAN AND XPO4;INTERACTION WITH XPO4;MUTAGENESIS OF 422-SER--SER-425
    34. 35.
      "Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS."
      Sun Y. , Ding L. , Zhang H. , Han J. , Yang X. , Yan J. , Zhu Y. , Li J. , Song H. , Ye Q.
      Nucleic Acids Res.34:6314-6326(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RBPMS
    35. 36.
      "3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins."
      Seong H.A. , Jung H. , Kim K.T. , Ha H.
      J. Biol. Chem.282:12272-12289(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION BY PDPK1;INTERACTION WITH PDPK1
    36. 37.
      "Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling."
      Arndt S. , Poser I. , Moser M. , Bosserhoff A.-K.
      Mol. Cell. Neurosci.34:603-611(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SKOR1
    37. 38.
      "Smad3 is acetylated by p300/CBP to regulate its transactivation activity."
      Inoue Y. , Itoh Y. , Abe K. , Okamoto T. , Daitoku H. , Fukamizu A. , Onozaki K. , Hayashi H.
      Oncogene26:500-508(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-378;FUNCTION;MUTAGENESIS OF LYS-333; LYS-341; LYS-378; LYS-409 AND 422-SER--SER-425
    38. 39.
      "TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal."
      Varelas X. , Sakuma R. , Samavarchi-Tehrani P. , Peerani R. , Rao B.M. , Dembowy J. , Yaffe M.B. , Zandstra P.W. , Wrana J.L.
      Nat. Cell Biol.10:837-848(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WWTR1
    39. 40.
      "Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling."
      Guo X. , Waddell D.S. , Wang W. , Wang Z. , Liberati N.T. , Yong S. , Liu X. , Wang X.-F.
      Oncogene27:7235-7247(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CSNK1G2;UBIQUITINATION;PHOSPHORYLATION AT SER-418 BY CSNK1G2/CK1;MUTAGENESIS OF SER-418
    40. 41.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-416;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    41. 42.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    42. 43.
      "Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling."
      Dai F. , Lin X. , Chang C. , Feng X.H.
      Dev. Cell16:345-357(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RANBP3;SUBCELLULAR LOCATION;FUNCTION
    43. 44.
      "SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells."
      Takahata M. , Inoue Y. , Tsuda H. , Imoto I. , Koinuma D. , Hayashi M. , Ichikura T. , Yamori T. , Nagasaki K. , Yoshida M. , Matsuoka M. , Morishita K. , Yuki K. , Hanyu A. , Miyazawa K. , Inazawa J. , Miyazono K. , Imamura T.
      J. Biol. Chem.284:3334-3344(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRDM16; SKI AND HDAC1
    44. 45.
      "Transforming growth factor-{beta}-inducible phosphorylation of Smad3."
      Wang G. , Matsuura I. , He D. , Liu F.
      J. Biol. Chem.284:9663-9673(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-179; SER-204 AND SER-208;SUBCELLULAR LOCATION;FUNCTION;MUTAGENESIS OF THR-179; SER-204 AND SER-208
    45. 46.
      "TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling."
      Watanabe Y. , Itoh S. , Goto T. , Ohnishi E. , Inamitsu M. , Itoh F. , Satoh K. , Wiercinska E. , Yang W. , Shi L. , Tanaka A. , Nakano N. , Mommaas A.M. , Shibuya H. , Ten Dijke P. , Kato M.
      Mol. Cell37:123-134(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PMEPA1
    46. 47.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IL1F7
    47. 48.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    48. 49.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION BY USP15;DNA-BINDING;INTERACTION WITH USP15;UBIQUITINATION AT LYS-33 AND LYS-81;MUTAGENESIS OF LYS-33; LYS-53 AND LYS-81
    49. 50.
      "Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-? pathway."
      Bruce D.L. , Macartney T. , Yong W. , Shou W. , Sapkota G.P.
      Cell. Signal.24:1999-2006(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP5C;SUBCELLULAR LOCATION
    50. 51.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    51. 52.
      "C18 ORF1, a novel negative regulator of transforming growth factor-beta signaling."
      Nakano N. , Maeyama K. , Sakata N. , Itoh F. , Akatsu R. , Nakata M. , Katsu Y. , Ikeno S. , Togawa Y. , Vo Nguyen T.T. , Watanabe Y. , Kato M. , Itoh S.
      J. Biol. Chem.289:12680-12692(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LDLRAD4
    52. 53.
      "Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor beta Signaling."
      Dahl M. , Maturi V. , Lonn P. , Papoutsoglou P. , Zieba A. , Vanlandewijck M. , van der Heide L.P. , Watanabe Y. , Soderberg O. , Hottiger M.O. , Heldin C.H. , Moustakas A.
      PLoS ONE9:E103651-E103651(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ADP-RIBOSYLATION
    53. 54.
      "Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling."
      Shi Y. , Wang Y.-F. , Jayaraman L. , Yang H. , Massague J. , Pavletich N.P.
      Cell94:585-594(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 1-144
    54. 55.
      "Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control."
      Qin B.Y. , Lam S.S. , Correia J.J. , Lin K.
      Genes Dev.16:1950-1963(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.74 ANGSTROMS) OF 220-425 IN COMPLEX WITH ZFYVE9
    55. 56.
      "Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding."
      Chai J. , Wu J.W. , Yan N. , Massague J. , Pavletich N.P. , Shi Y.
      J. Biol. Chem.278:20327-20331(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-144 IN COMPLEX WITH DNA;ZINC
    56. 57.
      "Structural basis of heteromeric smad protein assembly in TGF-beta signaling."
      Chacko B.M. , Qin B.Y. , Tiwari A. , Shi G. , Lam S. , Hayward L.J. , De Caestecker M. , Lin K.
      Mol. Cell15:813-823(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 228-424 IN COMPLEX WITH SMAD4;SUBUNIT
    57. 58.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-393
    58. 59.
      "Exome sequencing identifies SMAD3 mutations as a cause of familial thoracic aortic aneurysm and dissection with intracranial and other arterial aneurysms."
      Regalado E.S. , Guo D.C. , Villamizar C. , Avidan N. , Gilchrist D. , McGillivray B. , Clarke L. , Bernier F. , Santos-Cortez R.L. , Leal S.M. , Bertoli-Avella A.M. , Shendure J. , Rieder M.J. , Nickerson D.A. , Milewicz D.M.
      Circ. Res.109:680-686(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LDS3 VAL-112; LYS-239 AND LYS-279
    59. 60.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LDS3 ILE-261 AND TRP-287
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