SORL1 ELISA Kit for Human(Homo sapiens) | EIAab.comSORL1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SORL1(Gene name) > Human

SORL1 (Gene name),

Sortilin-related receptor (Protein name ), SORL_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SORL1(C11orf32);

Protein name:

Sortilin-related receptor;

Alternative:

SorLA-1;Low-density lipoprotein receptor relative with 11 ligand-binding repeats(LDLR relative with 11 ligand-binding repeats;LR11);Sorting protein-related receptor containing LDLR class A repeats(SorLA);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with GGA1 and ROCK2.

Function:

Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

2214

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2214:

MITGFSDDVP | MVIA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.368592

MIM:

104300

String:

Q92673

SMR:

Q92673

MIM:

602005

STRING:

9606.ENSP00000260197

KEGG:

hsa:6653

Pfam:

PF00041

Uniprot:

Q92673

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ELISA Kit for Human Sortilin-related receptor

Cat.:

E5512h

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Manual:

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Packing:

96T

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ELISA Kit for Human Sortilin-related receptor

MSDS:

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ELISA Kit for Human Sortilin-related receptor

Cat.:

E5512m

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MSDS:

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Packing:

96T

ELISA Kit for Human Sortilin-related receptor

MSDS:

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CLIA Kit for Human Sortilin-related receptor

MSDS:

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CLIA Kit for Human Sortilin-related receptor

MSDS:

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CLIA Kit for Human Sortilin-related receptor

Cat.:

U5512h

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MSDS:

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Packing:

96T

CLIA Kit for Human Sortilin-related receptor

Cat.:

U5512m

Price:

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MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Sortilin-related receptor

Cat.:

P5512Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Sortilin-related receptor

Cat.:

P5512Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Sortilin-related receptor

Monoclonal Antibody for Human Sortilin-related receptor

Protein for Human Sortilin-related receptor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"A novel mosaic protein containing LDL receptor elements is highly conserved in humans and chickens."
Morwald S. , Yamazaki H. , Bujo H. , Kusunoki J. , Kanaki T. , Seimiya K. , Morisaki N. , Nimpf J. , Schneider W.J. , Saito Y.
Arterioscler. Thromb. Vasc. Biol.17:996-1002(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS GLU-1074 AND ILE-1967
tissue: Brain.
2.

"Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein."
Jacobsen L. , Madsen P. , Moestrup S.K. , Lund A.H. , Tommerup N. , Nykjaer A. , Sottrup-Jensen L. , Gliemann J. , Petersen C.M.
J. Biol. Chem.271:31379-31383(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF N-TERMINUS;PARTIAL PROTEIN SEQUENCE;VARIANTS GLU-1074 AND ILE-1967
tissue: Brain.
tissue: T-cell.
3.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS GLU-1074 AND ILE-1967
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS GLU-1074 AND ILE-1967
tissue: Brain.
6.

"LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration."
Zhu Y. , Bujo H. , Yamazaki H. , Ohwaki K. , Jiang M. , Hirayama S. , Kanaki T. , Shibasaki M. , Takahashi K. , Schneider W.J. , Saito Y.
Circ. Res.94:752-758(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PLAUR
7.

"Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein."
Andersen O.M. , Reiche J. , Schmidt V. , Gotthardt M. , Spoelgen R. , Behlke J. , von Arnim C.A. , Breiderhoff T. , Jansen P. , Wu X. , Bales K.R. , Cappai R. , Masters C.L. , Gliemann J. , Mufson E.J. , Hyman B.T. , Paul S.M. , Nykjaer A. , more...
Proc. Natl. Acad. Sci. U.S.A.102:13461-13466(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APP TRAFFICKING;SUBCELLULAR LOCATION;INTERACTION WITH APP;TISSUE SPECIFICITY
8.

"No association of SORL1 SNPs with Alzheimer's disease."
Minster R.L. , DeKosky S.T. , Kamboh M.I.
Neurosci. Lett.440:190-192(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LACK OF ASSOCIATION WITH SUSCEPTIBILITY TO LATE-ONSET ALZHEIMER DISEASE
9.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-99; ASN-1733; ASN-2010; ASN-2076 AND ASN-2092
tissue: Liver.
10.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"Meta-analysis of the association between variants in SORL1 and Alzheimer disease."
Genetic and Environmental Risk in Alzheimer Disease 1 Consortium , Reitz C. , Cheng R. , Rogaeva E. , Lee J.H. , Tokuhiro S. , Zou F. , Bettens K. , Sleegers K. , Tan E.K. , Kimura R. , Shibata N. , Arai H. , Kamboh M.I. , Prince J.A. , Maier W. , Riemenschneider M. , Owen M. , more...
Arch. Neurol.68:99-106(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN AD
12.

"Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production."
Herskowitz J.H. , Seyfried N.T. , Gearing M. , Kahn R.A. , Peng J. , Levey A.I. , Lah J.J.
J. Biol. Chem.286:6117-6127(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-2206;INTERACTION WITH ROCK2
13.

"SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians."
Alzheimer Disease Genetics Consortium , Miyashita A. , Koike A. , Jun G. , Wang L.S. , Takahashi S. , Matsubara E. , Kawarabayashi T. , Shoji M. , Tomita N. , Arai H. , Asada T. , Harigaya Y. , Ikeda M. , Amari M. , Hanyu H. , Higuchi S. , Ikeuchi T. , more...
PLoS ONE8:E58618-E58618(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN AD
14.

"Solution structure of the second FN3 domain of human SORLA/LR11."
RIKEN structural genomics initiative (RSGI)
Submitted (2006-10) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1651-1745
15.

"GGA autoinhibition revisited."
Cramer J.F. , Gustafsen C. , Behrens M.A. , Oliveira C.L. , Pedersen J.S. , Madsen P. , Petersen C.M. , Thirup S.S.
Traffic11:259-273(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 2202-2214 IN COMPLEX WITH GGA1;INTERACTION WITH GGA1
16.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-120; LEU-1581 AND VAL-1972
17.

"SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population."
Bettens K. , Brouwers N. , Engelborghs S. , De Deyn P.P. , Van Broeckhoven C. , Sleegers K.
Hum. Mutat.29:769-770(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE ASSOCIATION WITH SUSCEPTIBILITY TO LATE-ONSET ALZHEIMER DISEASE;VARIANT THR-528
18.

"High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease."
PHRC GMAJ Collaborators , Pottier C. , Hannequin D. , Coutant S. , Rovelet-Lecrux A. , Wallon D. , Rousseau S. , Legallic S. , Paquet C. , Bombois S. , Pariente J. , Thomas-Anterion C. , Michon A. , Croisile B. , Etcharry-Bouyx F. , Berr C. , Dartigues J.F. , Amouyel P. , more...
Mol. Psychiatry17:875-879(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AD CYS-141; ARG-511; SER-924; SER-1358 AND ASP-1681

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