Gene name:
SORL1 (C11orf32) ;
Protein name:
Sortilin-related receptor ;
Alternative:
SorLA-1 ;Low-density lipoprotein receptor relative with 11 ligand-binding repeats (LDLR relative with 11 ligand-binding repeats;LR11) ;Sorting protein-related receptor containing LDLR class A repeats (SorLA) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with GGA1 and ROCK2.
Function:
Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MATRSSRRES | RLPFLFTLVA | LLPPGALCEV | WTQRLHGGSA | PLPQDRGFLV |
100:
VQGDPRELRL | WARGDARGAS | RADEKPLRRK | RSAALQPEPI | KVYGQVSLND |
150:
SHNQMVVHWA | GEKSNVIVAL | ARDSLALARP | KSSDVYVSYD | YGKSFKKISD |
200:
KLNFGLGNRS | EAVIAQFYHS | PADNKRYIFA | DAYAQYLWIT | FDFCNTLQGF |
250:
SIPFRAADLL | LHSKASNLLL | GFDRSHPNKQ | LWKSDDFGQT | WIMIQEHVKS |
300:
FSWGIDPYDK | PNTIYIERHE | PSGYSTVFRS | TDFFQSRENQ | EVILEEVRDF |
350:
QLRDKYMFAT | KVVHLLGSEQ | QSSVQLWVSF | GRKPMRAAQF | VTRHPINEYY |
400:
IADASEDQVF | VCVSHSNNRT | NLYISEAEGL | KFSLSLENVL | YYSPGGAGSD |
450:
TLVRYFANEP | FADFHRVEGL | QGVYIATLIN | GSMNEENMRS | VITFDKGGTW |
500:
EFLQAPAFTG | YGEKINCELS | QGCSLHLAQR | LSQLLNLQLR | RMPILSKESA |
550:
PGLIIATGSV | GKNLASKTNV | YISSSAGARW | REALPGPHYY | TWGDHGGIIT |
600:
AIAQGMETNE | LKYSTNEGET | WKTFIFSEKP | VFVYGLLTEP | GEKSTVFTIF |
650:
GSNKENVHSW | LILQVNATDA | LGVPCTENDY | KLWSPSDERG | NECLLGHKTV |
700:
FKRRTPHATC | FNGEDFDRPV | VVSNCSCTRE | DYECDFGFKM | SEDLSLEVCV |
750:
PDPEFSGKSY | SPPVPCPVGS | TYRRTRGYRK | ISGDTCSGGD | VEARLEGELV |
800:
PCPLAEENEF | ILYAVRKSIY | RYDLASGATE | QLPLTGLRAA | VALDFDYEHN |
850:
CLYWSDLALD | VIQRLCLNGS | TGQEVIINSG | LETVEALAFE | PLSQLLYWVD |
900:
AGFKKIEVAN | PDGDFRLTIV | NSSVLDRPRA | LVLVPQEGVM | FWTDWGDLKP |
950:
GIYRSNMDGS | AAYHLVSEDV | KWPNGISVDD | QWIYWTDAYL | ECIERITFSG |
1000:
QQRSVILDNL | PHPYAIAVFK | NEIYWDDWSQ | LSIFRASKYS | GSQMEILANQ |
1050:
LTGLMDMKIF | YKGKNTGSNA | CVPRPCSLLC | LPKANNSRSC | RCPEDVSSSV |
1100:
LPSGDLMCDC | PQGYQLKNNT | CVKQENTCLR | NQYRCSNGNC | INSIWWCDFD |
1150:
NDCGDMSDER | NCPTTICDLD | TQFRCQESGT | CIPLSYKCDL | EDDCGDNSDE |
1200:
SHCEMHQCRS | DEYNCSSGMC | IRSSWVCDGD | NDCRDWSDEA | NCTAIYHTCE |
1250:
ASNFQCRNGH | CIPQRWACDG | DTDCQDGSDE | DPVNCEKKCN | GFRCPNGTCI |
1300:
PSSKHCDGLR | DCSDGSDEQH | CEPLCTHFMD | FVCKNRQQCL | FHSMVCDGII |
1350:
QCRDGSDEDA | AFAGCSQDPE | FHKVCDEFGF | QCQNGVCISL | IWKCDGMDDC |
1400:
GDYSDEANCE | NPTEAPNCSR | YFQFRCENGH | CIPNRWKCDR | ENDCGDWSDE |
1450:
KDCGDSHILP | FSTPGPSTCL | PNYYRCSSGT | CVMDTWVCDG | YRDCADGSDE |
1500:
EACPLLANVT | AASTPTQLGR | CDRFEFECHQ | PKTCIPNWKR | CDGHQDCQDG |
1550:
RDEANCPTHS | TLTCMSREFQ | CEDGEACIVL | SERCDGFLDC | SDESDEKACS |
1600:
DELTVYKVQN | LQWTADFSGD | VTLTWMRPKK | MPSASCVYNV | YYRVVGESIW |
1650:
KTLETHSNKT | NTVLKVLKPD | TTYQVKVQVQ | CLSKAHNTND | FVTLRTPEGL |
1700:
PDAPRNLQLS | LPREAEGVIV | GHWAPPIHTH | GLIREYIVEY | SRSGSKMWAS |
1750:
QRAASNFTEI | KNLLVNTLYT | VRVAAVTSRG | IGNWSDSKSI | TTIKGKVIPP |
1800:
PDIHIDSYGE | NYLSFTLTME | SDIKVNGYVV | NLFWAFDTHK | QERRTLNFRG |
1850:
SILSHKVGNL | TAHTSYEISA | WAKTDLGDSP | LAFEHVMTRG | VRPPAPSLKA |
1900:
KAINQTAVEC | TWTGPRNVVY | GIFYATSFLD | LYRNPKSLTT | SLHNKTVIVS |
1950:
KDEQYLFLVR | VVVPYQGPSS | DYVVVKMIPD | SRLPPRHLHV | VHTGKTSVVI |
2000:
KWESPYDSPD | QDLLYAVAVK | DLIRKTDRSY | KVKSRNSTVE | YTLNKLEPGG |
2050:
KYHIIVQLGN | MSKDSSIKIT | TVSLSAPDAL | KIITENDHVL | LFWKSLALKE |
2100:
KHFNESRGYE | IHMFDSAMNI | TAYLGNTTDN | FFKISNLKMG | HNYTFTVQAR |
2150:
CLFGNQICGE | PAILLYDELG | SGADASATQA | ARSTDVAAVV | VPILFLILLS |
2200:
LGVGFAILYT | KHRRLQSSFT | AFANSHYSSR | LGSAIFSSGD | DLGEDDEDAP |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
Rabbit
ELISA Kit for Human Sortilin-related receptor
ELISA Kit for Human Sortilin-related receptor
ELISA Kit for Human Sortilin-related receptor
ELISA Kit for Human Sortilin-related receptor
CLIA Kit for Human Sortilin-related receptor
CLIA Kit for Human Sortilin-related receptor
CLIA Kit for Human Sortilin-related receptor
CLIA Kit for Human Sortilin-related receptor
Polyclonal Antibody for Human Sortilin-related receptor
Polyclonal Antibody for Human Sortilin-related receptor
Polyclonal Antibody for Human Sortilin-related receptor
Polyclonal Antibody for Human Sortilin-related receptor
Monoclonal Antibody for Human Sortilin-related receptor
Monoclonal Antibody for Human Sortilin-related receptor
Monoclonal Antibody for Human Sortilin-related receptor
Monoclonal Antibody for Human Sortilin-related receptor
Protein for Human Sortilin-related receptor
Protein for Human Sortilin-related receptor
Protein for Human Sortilin-related receptor
Protein for Human Sortilin-related receptor
R&D Technical Data
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Precision
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Recovery
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Linearity
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Meeh P.
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Markowitz S.D.
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Willis J.
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Dawson D.
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Willson J.K.V.
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Gazdar A.F.
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Hartigan J.
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Wu L.
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Liu C.
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Parmigiani G.
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Park B.H.
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Vogelstein B.
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Kinzler K.W.
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Velculescu V.E.
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Science314:268-274(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS [LARGE SCALE ANALYSIS] SER-120; LEU-1581 AND VAL-1972
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : POSSIBLE ASSOCIATION WITH SUSCEPTIBILITY TO LATE-ONSET ALZHEIMER DISEASE;VARIANT THR-528
18.
"High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease."
PHRC GMAJ Collaborators
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Coutant S.
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Paquet C.
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Pariente J.
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Thomas-Anterion C.
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Michon A.
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Croisile B.
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Etcharry-Bouyx F.
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Dartigues J.F.
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Campion D.
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Mol. Psychiatry17:875-879(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS AD CYS-141; ARG-511; SER-924; SER-1358 AND ASP-1681