TCF7L2 ELISA Kit for Human(Homo sapiens) | EIAab.comTCF7L2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > TCF7L2(Gene name) > Human

TCF7L2 (Gene name),

Transcription factor 7-like 2 (Protein name ), TF7L2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TCF7L2(TCF4);

Protein name:

Transcription factor 7-like 2;

Alternative:

T-cell-specific transcription factor 4(T-cell factor 4;TCF-4;hTCF-4);HMG box transcription factor 4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with TGFB1I1 (By similarity). Interacts with CTNNB1 (via the armadillo repeat); forms stable transcription complex. Interacts with EP300. Interacts with NLK. Interacts with CCDC85B (probably through the HMG box); prevents interaction with CTNNB1. Interacts with TNIK. Interacts with MAD2L2; prevents TCF7L2/TCF4 binding to promoters, negatively modulating its transcriptional activity.

Function:

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.

Subcellular Location:

Nucleus PML body Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies.

Protein Attributes:

Sequence length:

619

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

619:

SSLAGTQPQP | LSLVTKSLE

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

Pfam:

PF08347

SMR:

Q9NQB0

String:

Q9NQB0

UniGene:

Hs.593995

MIM:

125853

KEGG:

hsa:6934

Uniprot:

Q9NQB0

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ELISA Kit for Human Transcription factor 7-like 2

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E5449h

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96T

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ELISA Kit for Human Transcription factor 7-like 2

Cat.:

E5449m

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Manual:

Looking for manual.

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96T

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CLIA Kit for Human Transcription factor 7-like 2

Cat.:

U5449h

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96T

CLIA Kit for Human Transcription factor 7-like 2

Cat.:

U5449m

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96T

Polyclonal Antibody for Human Transcription factor 7-like 2

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P5449Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Transcription factor 7-like 2

Cat.:

P5449Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Transcription factor 7-like 2

Protein for Human Transcription factor 7-like 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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References

1.

"Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma."
Korinek V. , Barker N. , Morin P.J. , van Wichen D. , de Weger R. , Kinzler K.W. , Vogelstein B. , Clevers H.
Science275:1784-1787(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 8 AND 9);INTERACTION WITH CTNNB1
tissue: Fetus.
2.

"The human T cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines."
Duval A. , Rolland S. , Tubacher E. , Bui H. , Thomas G. , Hamelin R.
Cancer Res.60:3872-3879(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7 AND 9);VARIANT ASN-346
3.

"Tissue-specific alternative splicing of TCF7L2."
Prokunina-Olsson L. , Welch C. , Hansson O. , Adhikari N. , Scott L.J. , Usher N. , Tong M. , Sprau A. , Swift A. , Bonnycastle L.L. , Erdos M.R. , He Z. , Saxena R. , Harmon B. , Kotova O. , Hoffman E.P. , Altshuler D. , Groop L. , more...
Hum. Mol. Genet.18:3795-3804(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 12; 13 AND 14);ALTERNATIVE SPLICING
tissue: Brain.
4.

"Identification of T-cell factor-4 isoforms that contribute to the malignant phenotype of hepatocellular carcinoma cells."
Tsedensodnom O. , Koga H. , Rosenberg S.A. , Nambotin S.B. , Carroll J.J. , Wands J.R. , Kim M.
Exp. Cell Res.317:920-931(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 6; 9; 13; 14; 15 AND 17);ALTERNATIVE SPLICING
5.

"ALEX1, a putative tumor suppressor, is regulated by CREB-dependent Wnt signaling, and is silenced by promoter methylation in human colorectal cancer."
Iseki H. , Takeda A. , Andou T. , Takahashi N. , Ban S. , Kurochkin I.V. , Okazaki Y. , Koyama I.
Submitted (2008-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 9)
tissue: Colon.
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 14)
7.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 10)
tissue: Uterus.
10.

"Human TCF-4 splice form B."
Saeki H. , Tanaka S. , Sugimachi K.
Submitted (1999-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 449-494
tissue: Gastric carcinoma.
11.

"Identification of c-MYC as a target of the APC pathway."
He T.-C. , Sparks A.B. , Rago C. , Hermeking H. , Zawel L. , da Costa L.T. , Morin P.J. , Vogelstein B. , Kinzler K.W.
Science281:1509-1512(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium."
Barker N. , Huls G. , Korinek V. , Clevers H.
Am. J. Pathol.154:29-35(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INTERACTION WITH CTNNB1;SUBCELLULAR LOCATION
13.

"Identification of Tcf4 residues involved in high-affinity beta-catenin binding."
Omer C.A. , Miller P.J. , Diehl R.E. , Kral A.M.
Biochem. Biophys. Res. Commun.256:584-590(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CTNNB1;MUTAGENESIS OF 10-ASP-ASP-11; ASP-16; GLU-17; 23-ASP-GLU-24 AND LEU-48
14.

"All Tcf HMG box transcription factors interact with Groucho-related co-repressors."
Brantjes H. , Roose J. , van De Wetering M. , Clevers H.
Nucleic Acids Res.29:1410-1419(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TLE1; TLE2; TLE3 AND TLE4
15.

"The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells."
van de Wetering M. , Sancho E. , Verweij C. , de Lau W. , Oving I. , Hurlstone A. , van der Horn K. , Batlle E. , Coudreuse D. , Haramis A.-P. , Tjon-Pon-Fong M. , Moerer P. , van den Born M. , Soete G. , Pals S. , Eilers M. , Medema R. , Clevers H.
Cell111:241-250(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
16.

"Sumoylation is involved in beta-catenin-dependent activation of Tcf-4."
Yamamoto H. , Ihara M. , Matsuura Y. , Kikuchi A.
EMBO J.22:2047-2059(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-320;INTERACTION WITH PIAS4;FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-320 AND GLU-322
17.

"Identification of a promoter-specific transcriptional activation domain at the C-terminus of the Wnt effector protein T-cell factor 4."
Hecht A. , Stemmler M.P.
J. Biol. Chem.278:3776-3785(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EP300
18.

"Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling."
Ishitani T. , Ninomiya-Tsuji J. , Matsumoto K.
Mol. Cell. Biol.23:1379-1389(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NLK;PHOSPHORYLATION AT THR-201 AND/OR THR-212 BY NLK;MUTAGENESIS OF THR-201 AND THR-212
19.

"NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)."
Yamada M. , Ohnishi J. , Ohkawara B. , Iemura S. , Satoh K. , Hyodo-Miura J. , Kawachi K. , Natsume T. , Shibuya H.
J. Biol. Chem.281:20749-20760(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NLK
20.

"Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes."
Grant S.F.A. , Thorleifsson G. , Reynisdottir I. , Benediktsson R. , Manolescu A. , Sainz J. , Helgason A. , Stefansson H. , Emilsson V. , Helgadottir A. , Styrkarsdottir U. , Magnusson K.P. , Walters G.B. , Palsdottir E. , Jonsdottir T. , Gudmundsdottir T. , Gylfason A. , Saemundsdottir J. , more...
Nat. Genet.38:320-323(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN NIDDM
21.

"The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals."
Horndasch M. , Lienkamp S. , Springer E. , Schmitt A. , Pavenstaedt H. , Walz G. , Gloy J.
Oncogene25:3397-3407(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DDIT3
22.

"Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner."
Iwai A. , Hijikata M. , Hishiki T. , Isono O. , Chiba T. , Shimotohno K.
Oncogene27:1520-1526(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CCDC85B
23.

"The kinase TNIK is an essential activator of Wnt target genes."
Mahmoudi T. , Li V.S.W. , Ng S.S. , Taouatas N. , Vries R.G.J. , Mohammed S. , Heck A.J. , Clevers H.
EMBO J.28:3329-3340(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNIK AND CTNNB1
24.

"MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation."
Hong C.F. , Chou Y.T. , Lin Y.S. , Wu C.W.
J. Biol. Chem.284:19613-19622(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MAD2L2
25.

"Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4)."
Togi S. , Ikeda O. , Kamitani S. , Nakasuji M. , Sekine Y. , Muromoto R. , Nanbo A. , Oritani K. , Kawai T. , Akira S. , Matsuda T.
J. Biol. Chem.286:19170-19177(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NLK AND ZIPK/DAPK3
26.

"Kindlin 2 forms a transcriptional complex with beta-catenin and TCF4 to enhance Wnt signalling."
Yu Y. , Wu J. , Wang Y. , Zhao T. , Ma B. , Liu Y. , Fang W. , Zhu W.G. , Zhang H.
EMBO Rep.13:750-758(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN A COMPLEX WITH FERMT2 AND CTNNB1;SUBCELLULAR LOCATION
27.

"Beta-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells."
Satow R. , Shitashige M. , Jigami T. , Fukami K. , Honda K. , Kitabayashi I. , Yamada T.
Gastroenterology142:572-581(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PML
28.

"SPINDLIN1 promotes cancer cell proliferation through activation of WNT/TCF-4 signaling."
Wang J.X. , Zeng Q. , Chen L. , Du J.C. , Yan X.L. , Yuan H.F. , Zhai C. , Zhou J.N. , Jia Y.L. , Yue W. , Pei X.T.
Mol. Cancer Res.10:326-335(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPIN1
29.

"XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling."
Hanson A.J. , Wallace H.A. , Freeman T.J. , Beauchamp R.D. , Lee L.A. , Lee E.
Mol. Cell45:619-628(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH XIAP/BIRC4 AND TLE3
30.

"Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1."
Su X. , Zhu G. , Ding X. , Lee S.Y. , Dou Y. , Zhu B. , Wu W. , Li H.
Genes Dev.28:622-636(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPIN1
31.

"Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico."
The SIGMA Type 2 Diabetes Consortium
Nature506:97-101(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN NIDDM
32.

"Tcf4 can specifically recognize beta-catenin using alternative conformations."
Graham T.A. , Ferkey D.M. , Mao F. , Kimelman D. , Xu W.
Nat. Struct. Biol.8:1048-1052(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 12-49 IN COMPLEX WITH THE ARMADILLO REPEAT REGION OF CTNNB1;MUTAGENESIS OF GLU-24; GLU-26; GLU-28 AND GLU-29
33.

"Structure of a human Tcf4-beta-catenin complex."
Poy F. , Lepourcelet M. , Shivdasani R.A. , Eck M.J.
Nat. Struct. Biol.8:1053-1057(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 8-54 IN COMPLEX WITH THE ARMADILLO REPEAT REGION OF CTNNB1;MUTAGENESIS OF ILE-19 AND PHE-21
34.

"Crystal structure of a beta-catenin/BCL9/Tcf4 complex."
Sampietro J. , Dahlberg C.L. , Cho U.S. , Hinds T.R. , Kimelman D. , Xu W.
Mol. Cell24:293-300(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 1-53 IN COMPLEX WITH BCL9 AND CTNNB1;INTERACTION WITH CTNNB1
35.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-465

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