Gene name:
TNFSF12 (UNQ181/PRO207;APO3L;DR3LG) ;
Protein name:
Tumor necrosis factor ligand superfamily member 12 ;
Alternative:
TNF-related weak inducer of apoptosis (TWEAK) ;APO3 ligand ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homotrimer (Potential). Interacts with the angiogenic factor AGGF1/VG5Q.
Function:
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.
Subcellular Location:
Tumor necrosis factor ligand superfamily member 12, secreted form
Secreted
Protein Attributes:
50:
MAARRSQRRR | GRRGEPGTAL | LVPLALGLGL | ALACLGLLLA | VVSLGSRASL |
100:
SAQEPAQEEL | VAEEDQDPSE | LNPQTEESQD | PAPFLNRLVR | PRRSAPKGRK |
150:
TRARRAIAAH | YEVHPRPGQD | GAQAGVDGTV | SGWEEARINS | SSPLRYNRQI |
200:
GEFIVTRAGL | YYLYCQVHFD | EGKAVYLKLD | LLVDGVLALR | CLEEFSATAA |
249:
SSLGPQLRLC | QVSGLLALRP | GSSLRIRTLP | WAHLKAAPFL | TYFGLFQVH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Tumor necrosis factor ligand superfamily member 12
ELISA Kit for Human Tumor necrosis factor ligand superfamily member 12
CLIA Kit for Human Tumor necrosis factor ligand superfamily member 12
CLIA Kit for Human Tumor necrosis factor ligand superfamily member 12
Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 12
Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 12
Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 12
Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 12
Protein for Human Tumor necrosis factor ligand superfamily member 12
Protein for Human Tumor necrosis factor ligand superfamily member 12
R&D Technical Data
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Precision
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Recovery
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Linearity
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