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Index > Protein center > TNFSF18(Gene name) > Human
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  • TNFSF18 (Gene name),
  • Tumor necrosis factor ligand superfamily member 18 (Protein name ),  TNF18_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TNFSF18(UNQ149/PRO175;AITRL;GITRL;TL6);
    Protein name:
    Tumor necrosis factor ligand superfamily member 18;
    Alternative:
    Glucocorticoid-induced TNF-related ligand(hGITRL);Activation-inducible TNF-related ligand(AITRL);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer.
    Function:
    Cytokine that binds to TNFRSF18/AITR/GITR. Important for interactions between activated T-lymphocytes and endothelial cells and may modulate T-lymphocyte survival in peripheral tissues.
    Subcellular Location:
    Membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    199
    Sequence:
    50:
    MTLHPSPITC | EFLFSTALIS | PKMCLSHLEN | MPLSHSRTQG | AQRSSWKLWL | 
    100:
    FCSIVMLLFL | CSFSWLIFIF | LQLETAKEPC | MAKFGPLPSK | WQMASSEPPC | 
    150:
    VNKVSDWKLE | ILQNGLYLIY | GQVAPNANYN | DVAPFEVRLY | KNKDMIQTLT | 
    199:
    NKSKIQNVGG | TYELHVGDTI | DLIFNSEHQV | LKNNTYWGII | LLANPQFIS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    SMR:
    KEGG:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tumor necrosis factor ligand superfamily member 18
    Cat.:
    E8960h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Tumor necrosis factor ligand superfamily member 18
    Cat.:
    E8960m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Tumor necrosis factor ligand superfamily member 18
    Cat.:
    U8960h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Tumor necrosis factor ligand superfamily member 18
    Cat.:
    U8960m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 18
    Cat.:
    P8960Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 18
    Cat.:
    P8960Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 18
    Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 18
    Protein for Human Tumor necrosis factor ligand superfamily member 18
    Protein for Human Tumor necrosis factor ligand superfamily member 18

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-199
    5. 5.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-199
    6. 6.
      "Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR."
      Gurney A.L. , Marsters S.A. , Huang R.M. , Pitti R.M. , Mark D.T. , Baldwin D.T. , Gray A.M. , Dowd A.D. , Brush A.D. , Heldens A.D. , Schow A.D. , Goddard A.D. , Wood W.I. , Baker K.P. , Godowski P.J. , Ashkenazi A.
      Curr. Biol.9:215-218(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-199
      tissue: Umbilical vein.
    7. 7.
      "Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand."
      Kwon B. , Yu K.-Y. , Ni J. , Yu G.-L. , Jang I.-K. , Kim Y.-J. , Xing L. , Liu D. , Wang S.-X. , Kwon B.S.
      J. Biol. Chem.274:6056-6061(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-199
      tissue: Brain.
    8. 8.
      "Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells."
      Tuyaerts S. , Van Meirvenne S. , Bonehill A. , Heirman C. , Corthals J. , Waldmann H. , Breckpot K. , Thielemans K. , Aerts J.L.
      J. Leukoc. Biol.82:93-105(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    9. 9.
      "Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion."
      Lacal P.M. , Petrillo M.G. , Ruffini F. , Muzi A. , Bianchini R. , Ronchetti S. , Migliorati G. , Riccardi C. , Graziani G. , Nocentini G.
      J. Pharmacol. Exp. Ther.347:164-172(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: implications for function."
      Chattopadhyay K. , Ramagopal U.A. , Mukhopadhaya A. , Malashkevich V.N. , Dilorenzo T.P. , Brenowitz M. , Nathenson S.G. , Almo S.C.
      Proc. Natl. Acad. Sci. U.S.A.104:19452-19457(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 74-199;FUNCTION;SUBUNIT;DISULFIDE BOND
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