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Index > Protein center > TNFRSF1B(Gene name) > Human
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  • TNFRSF1B (Gene name),
  • Tumor necrosis factor receptor superfamily member 1B (Protein name ),  TNR1B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (2)
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  • Gene name:
    TNFRSF1B(TNFBR;TNFR2);
    Protein name:
    Tumor necrosis factor receptor superfamily member 1B;
    Alternative:
    p80 TNF-alpha receptor;p75;Tumor necrosis factor receptor 2(TNF-R2);Tumor necrosis factor receptor type II(TNF-RII;TNFR-II);
    CD:
    CD120b;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds to TRAF2. Interacts with BMX.
    Function:
    Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
    Subcellular Location:
    Tumor necrosis factor-binding protein 2 Secreted
    Protein Attributes:
    Sequence length:
    461
    Sequence:
    50:
    MAPVAVWAAL | AVGLELWAAA | HALPAQVAFT | PYAPEPGSTC | RLREYYDQTA | 
    100:
    QMCCSKCSPG | QHAKVFCTKT | SDTVCDSCED | STYTQLWNWV | PECLSCGSRC | 
    150:
    SSDQVETQAC | TREQNRICTC | RPGWYCALSK | QEGCRLCAPL | RKCRPGFGVA | 
    200:
    RPGTETSDVV | CKPCAPGTFS | NTTSSTDICR | PHQICNVVAI | PGNASMDAVC | 
    250:
    TSTSPTRSMA | PGAVHLPQPV | STRSQHTQPT | PEPSTAPSTS | FLLPMGPSPP | 
    300:
    AEGSTGDFAL | PVGLIVGVTA | LGLLIIGVVN | CVIMTQVKKK | PLCLQREAKV | 
    350:
    PHLPADKARG | TQGPEQQHLL | ITAPSSSSSS | LESSASALDR | RAPTRNQPQA | 
    400:
    PGVEASGAGE | ARASTGSSDS | SPGGHGTQVN | VTCIVNVCSS | SDHSSQCSSQ | 
    450:
    ASSTMGDTDS | SPSESPKDEQ | VPFSKEECAF | RSQLETPETL | LGSTEEKPLP | 
    461:
    LGVPDAGMKP | S
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    String:
    MIM:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 1B
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    E0132h
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    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 1B
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    E0132m
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    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 1B
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    E0132r
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    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 1B
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    U0132m
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    Packing:
    96T
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 1B
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    U0132h
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    96T
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 1B
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    U0132r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1B
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    P0132Rb-r
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    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1B
    Cat.:
    P0132Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1B
    Cat.:
    P0132Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1B
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1B
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1B
    Protein for Human Tumor necrosis factor receptor superfamily member 1B
    Protein for Human Tumor necrosis factor receptor superfamily member 1B
    Cat.:
    R0132h
    Price:
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    Packing:
    1mg
    Purity:
    >90%
    Protein for Human Tumor necrosis factor receptor superfamily member 1B

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    References
    1. 1.
      "A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor."
      Kohno T. , Brewer M.T. , Baker S.L. , Schwartz P.E. , King M.W. , Hale K.K. , Squires C.H. , Thompson R.C. , Vannice J.L.
      Proc. Natl. Acad. Sci. U.S.A.87:8331-8335(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-196
    2. 2.
      "A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins."
      Smith C.A. , Davis T. , Anderson D. , Solam L. , Beckmann M.P. , Jerzy R. , Dower S.K. , Cosman D. , Goodwin R.G.
      Science248:1019-1023(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    4. 4.
      "Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2."
      Lainez B. , Fernandez-Real J.M. , Romero X. , Esplugues E. , Canete J.D. , Ricart W. , Engel P.
      Int. Immunol.16:169-177(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);SUBCELLULAR LOCATION;FUNCTION (ISOFORM 2)
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      NIEHS SNPs program
      Submitted (2003-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS MET-187; ARG-196; LYS-232; THR-236; PRO-264 AND ARG-295
    7. 7.
      SeattleSNPs variation discovery resource
      Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-196; LYS-232; PRO-269 AND ARG-301
    8. 8.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: PNS.
    11. 11.
      "Purification and partial amino acid sequence analysis of two distinct tumor necrosis factor receptors from HL60 cells."
      Loetscher H. , Schlaeger E.J. , Lahm H.-W. , Pan Y.-C.E. , Lesslauer W. , Brockhaus M.
      J. Biol. Chem.265:20131-20138(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-40; 65-69; 136-141; 300-306 AND 346-362
    12. 12.
      "Purification of two types of TNF inhibitors in the urine of the patient with chronic glomerulonephritis."
      Suzuki J. , Tomizawa S. , Arai H. , Seki Y. , Maruyama K. , Kuroume T.
      Nephron66:386-390(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-37
      tissue: Urine.
    13. 13.
      "Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors."
      Engelmann H. , Novick D. , Wallach D.
      J. Biol. Chem.265:1531-1536(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-31
      tissue: Urine.
    14. 14.
      "Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences."
      Dembic Z. , Loetscher H. , Gubler U. , Pan Y.C. , Lahm H.-W. , Gentz R. , Brockhaus M. , Lesslauer W.
      Cytokine2:231-237(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-461 (ISOFORM 1)
    15. 15.
      "Complementary DNA cloning of a receptor for tumor necrosis factor and demonstration of a shed form of the receptor."
      Heller R.A. , Song K. , Onasch M.A. , Fischer W.H. , Chang D. , Ringold G.M.
      Proc. Natl. Acad. Sci. U.S.A.87:6151-6155(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 116-461 (ISOFORM 1);PARTIAL PROTEIN SEQUENCE;VARIANT ARG-196
    16. 16.
      "New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus."
      Tsuchiya N. , Komata T. , Matsushita M. , Ohashi J. , Tokunaga K.
      Genes Immun.1:501-503(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 154-183;VARIANTS ARG-196 AND LYS-232
    17. 17.
      "Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization, and receptor phosphorylation."
      Pennica D. , Lam V.T. , Mize N.K. , Weber R.F. , Lewis M. , Fendly B.M. , Lipari M.T. , Goeddel D.V.
      J. Biol. Chem.267:21172-21178(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    18. 18.
      "A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor."
      Rothe M. , Wong S.C. , Henzel W.J. , Goeddel D.V.
      Cell78:681-692(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAF2
    19. 19.
      "Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis."
      Pan S. , An P. , Zhang R. , He X. , Yin G. , Min W.
      Mol. Cell. Biol.22:7512-7523(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BMX
    20. 20.
      "Structural basis for self-association and receptor recognition of human TRAF2."
      Park Y.C. , Burkitt V. , Villa A.R. , Tong L. , Wu H.
      Nature398:533-538(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 419-428 IN COMPLEX WITH TRAF2
    21. 21.
      "Association of tumor necrosis factor receptor type II polymorphism 196R with systemic lupus erythematosus in the Japanese: molecular and functional analysis."
      Morita C. , Horiuchi T. , Tsukamoto H. , Hatta N. , Kikuchi Y. , Arinobu Y. , Otsuka T. , Sawabe T. , Harashima S. , Nagasawa K. , Niho Y.
      Arthritis Rheum.44:2819-2827(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARG-196 AND LYS-232
    22. 22.
      "Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism."
      Peral B. , San Millan J.L. , Castello R. , Moghetti P. , Escobar-Morreale H.F.
      J. Clin. Endocrinol. Metab.87:3977-3983(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-196
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