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Index > Protein center > TRIB3(Gene name) > Human
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  • TRIB3 (Gene name),
  • Tribbles homolog 3 (Protein name ),  TRIB3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TRIB3(C20orf97;NIPK;SKIP3;TRB3);
    Protein name:
    Tribbles homolog 3(TRB-3);
    Alternative:
    SINK;Neuronal cell death-inducible putative kinase;p65-interacting inhibitor of NF-kappa-B;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7.
    Function:
    Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    358
    Sequence:
    50:
    MRATPLAAPA | GSLSRKKRLE | LDDNLDTERP | VQKRARSGPQ | PRLPPCLLPL | 
    100:
    SPPTAPDRAT | AVATASRLGP | YVLLEPEEGG | RAYQALHCPT | GTEYTCKVYP | 
    150:
    VQEALAVLEP | YARLPPHKHV | ARPTEVLAGT | QLLYAFFTRT | HGDMHSLVRS | 
    200:
    RHRIPEPEAA | VLFRQMATAL | AHCHQHGLVL | RDLKLCRFVF | ADRERKKLVL | 
    250:
    ENLEDSCVLT | GPDDSLWDKH | ACPAYVGPEI | LSSRASYSGK | AADVWSLGVA | 
    300:
    LFTMLAGHYP | FQDSEPVLLF | GKIRRGAYAL | PAGLSAPARC | LVRCLLRREP | 
    350:
    AERLTATGIL | LHPWLRQDPM | PLAPTRSHLW | EAAQVVPDGL | GLDEAREEEG | 
    358:
    DREVVLYG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    SMR:
    Pfam:
    UniGene:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human TRB-3
    Cat.:
    E9844m
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    96T
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    ELISA Kit for Human TRB-3
    Cat.:
    E9844r
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    96T
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    ELISA Kit for Human TRB-3
    Cat.:
    E9844h
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    Packing:
    96T
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    ELISA Kit for Human TRB-3
    Cat.:
    E9844b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human TRB-3
    Cat.:
    U9844h
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    Packing:
    96T
    Range:
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    CLIA Kit for Human TRB-3
    Cat.:
    U9844b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TRB-3
    Cat.:
    U9844r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TRB-3
    Cat.:
    U9844m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human TRB-3
    Polyclonal Antibody for Human TRB-3
    Cat.:
    P9844Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human TRB-3
    Polyclonal Antibody for Human TRB-3
    Cat.:
    P9844Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human TRB-3
    Monoclonal Antibody for Human TRB-3
    Monoclonal Antibody for Human TRB-3
    Monoclonal Antibody for Human TRB-3
    Protein for Human TRB-3
    Protein for Human TRB-3
    Protein for Human TRB-3
    Protein for Human TRB-3

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    References
    1. 1.
      "SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia."
      Bowers A.J. , Scully S. , Boylan J.F.
      Oncogene22:2823-2835(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;INDUCTION;INTERACTION WITH ATF4
    2. 2.
      "SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription."
      Wu M. , Xu L.G. , Zhai Z. , Shu H.B.
      J. Biol. Chem.278:27072-27079(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;INDUCTION;INTERACTION WITH RELA
    3. 3.
      "Human tribbles, a protein family controlling mitogen-activated protein kinase cascades."
      Kiss-Toth E. , Bagstaff S.M. , Sung H.Y. , Jozsa V. , Dempsey C. , Caunt J.C. , Oxley K.M. , Wyllie D.H. , Polgar T. , Harte M. , O'Neill L.A.J. , Qwarnstrom E.E. , Dower S.K.
      J. Biol. Chem.279:42703-42708(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH MAP2K1 AND MAP2K7
    4. 4.
      "Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions."
      Ord D. , Ord T.
      Biochem. Biophys. Res. Commun.330:210-218(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
    5. 5.
      Shan Y.X. , Yu L.
      Submitted (2003-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    8. 8.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Liver.
    9. 9.
      "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
      Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ARG-84
      tissue: Cervix.
      tissue: Muscle.
    11. 11.
      "TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death."
      Ohoka N. , Yoshii S. , Hattori T. , Onozaki K. , Hayashi H.
      EMBO J.24:1243-1255(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;INTERACTION WITH DDIT3
    12. 12.
      "TRB3 is a PI 3-kinase dependent indicator for nutrient starvation."
      Schwarzer R. , Dames S. , Tondera D. , Klippel A. , Kaufmann J.
      Cell. Signal.18:899-909(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    13. 13.
      "Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion."
      Ohoka N. , Hattori T. , Kitagawa M. , Onozaki K. , Hayashi H.
      J. Biol. Chem.282:35687-35694(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DDIT3
    14. 14.
      "Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A."
      Aynaud M.M. , Suspene R. , Vidalain P.O. , Mussil B. , Guetard D. , Tangy F. , Wain-Hobson S. , Vartanian J.P.
      J. Biol. Chem.287:39182-39192(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH APOBEC3A AND APOBEC3C;SUBCELLULAR LOCATION
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