Gene name:
TRIB3 (C20orf97;NIPK;SKIP3;TRB3) ;
Protein name:
Tribbles homolog 3 (TRB-3) ;
Alternative:
SINK ;Neuronal cell death-inducible putative kinase ;p65-interacting inhibitor of NF-kappa-B ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with AKT1, AKT2, ATF4, MAP2K1 and MAP2K7.
Function:
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MRATPLAAPA | GSLSRKKRLE | LDDNLDTERP | VQKRARSGPQ | PRLPPCLLPL |
100:
SPPTAPDRAT | AVATASRLGP | YVLLEPEEGG | RAYQALHCPT | GTEYTCKVYP |
150:
VQEALAVLEP | YARLPPHKHV | ARPTEVLAGT | QLLYAFFTRT | HGDMHSLVRS |
200:
RHRIPEPEAA | VLFRQMATAL | AHCHQHGLVL | RDLKLCRFVF | ADRERKKLVL |
250:
ENLEDSCVLT | GPDDSLWDKH | ACPAYVGPEI | LSSRASYSGK | AADVWSLGVA |
300:
LFTMLAGHYP | FQDSEPVLLF | GKIRRGAYAL | PAGLSAPARC | LVRCLLRREP |
350:
AERLTATGIL | LHPWLRQDPM | PLAPTRSHLW | EAAQVVPDGL | GLDEAREEEG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
Bovine
ELISA Kit for Human TRB-3
ELISA Kit for Human TRB-3
ELISA Kit for Human TRB-3
ELISA Kit for Human TRB-3
Polyclonal Antibody for Human TRB-3
Polyclonal Antibody for Human TRB-3
Polyclonal Antibody for Human TRB-3
Polyclonal Antibody for Human TRB-3
Monoclonal Antibody for Human TRB-3
Monoclonal Antibody for Human TRB-3
Monoclonal Antibody for Human TRB-3
Monoclonal Antibody for Human TRB-3
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
P S Ratnaparkhi, N B Kulkarni, M U Ganu, et al.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS [LARGE SCALE ANALYSIS] ILE-60; ARG-84; HIS-153; HIS-274 AND LYS-347