UMOD ELISA Kit for Human(Homo sapiens) | EIAab.comUMOD ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > UMOD(Gene name) > Human

UMOD (Gene name),

Uromodulin (Protein name ), UROM_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

UMOD;

Protein name:

Uromodulin;

Alternative:

Tamm-Horsfall urinary glycoprotein(THP);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Function:

Uromodulin, secreted form: Secreted into urine after proteolytically cleaveage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals.

Subcellular Location:

Uromodulin, secreted form Secreted

Protein Attributes:

Sequence length:

640

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

640:

LGPITRKGVQ | ATVSRAFSSL | GLLKVWLPLL | LSATLTLTFQ |

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

STRING:

9606.ENSP00000306279

Pfam:

PF12947

String:

P07911

MIM:

162000

Pfam:

PF07645

UniGene:

Hs.654425

SMR:

P07911

KEGG:

hsa:7369

Uniprot:

P07911

FOR

ELISA Kit for Human Uromodulin

Cat.:

E2280m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Uromodulin

Cat.:

E2280h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Uromodulin

Cat.:

E2280r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Uromodulin

Cat.:

E2280d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Uromodulin

Cat.:

E2280b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Uromodulin

Cat.:

U2280b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Uromodulin

Cat.:

U2280m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Uromodulin

Cat.:

U2280h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Uromodulin

Cat.:

U2280r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Uromodulin

Cat.:

U2280d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Uromodulin

Cat.:

P2280Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Uromodulin

Cat.:

P2280Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Uromodulin

Cat.:

P2280Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Uromodulin

Monoclonal Antibody for Human Uromodulin

Protein for Human Uromodulin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein."
Pennica D. , Kohr W.J. , Kuang W.-J. , Glaister D. , Aggarwal B.B. , Chen E.Y. , Goeddel D.V.
Science236:83-88(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Uromodulin (Tamm-Horsfall glycoprotein): a renal ligand for lymphokines."
Hession C. , Decker J.M. , Sherblom A.P. , Kumar S. , Yue C.C. , Mattaliano R.J. , Tizard R. , Kawashima E. , Schmeissner U. , Heletky S. , Chow E.P. , Burne C.A. , Shaw A. , Muchmore A.V.
Science237:1479-1484(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
3.

"Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy."
Hart T.C. , Gorry M.C. , Hart P.S. , Woodard A.S. , Shihabi Z. , Sandhu J. , Shirts B. , Xu L. , Zhu H. , Barmada M.M. , Bleyer A.J.
J. Med. Genet.39:882-892(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HNFJ1 TYR-148 AND ARG-217;VARIANT MCKD2 CYS-103
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4 AND 5)
tissue: Kidney.
5.

"The sequence and analysis of duplication-rich human chromosome 16."
Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Kidney.
7.

"Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage."
Santambrogio S. , Cattaneo A. , Bernascone I. , Schwend T. , Jovine L. , Bachi A. , Rampoldi L.
Biochem. Biophys. Res. Commun.370:410-413(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 578-587;PROTEOLYTIC CLEAVAGE;IDENTIFICATION BY MASS SPECTROMETRY
8.

"Localization of Tamm-Horsfall glycoprotein in the human kidney using immuno-fluorescence and immuno-electron microscopical techniques."
Sikri K.L. , Foster C.L. , MacHugh N. , Marshall R.D.
J. Anat.132:597-605(1981) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION
9.

"Uromodulin (Tamm-Horsfall glycoprotein/uromucoid) is a phosphatidylinositol-linked membrane protein."
Rindler M.J. , Naik S.S. , Li N. , Hoops T.C. , Peraldi M.-N.
J. Biol. Chem.265:20784-20789(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GPI-ANCHOR
10.

"Uromodulin facilitates neutrophil migration across renal epithelial monolayers."
Schmid M. , Prajczer S. , Gruber L.N. , Bertocchi C. , Gandini R. , Pfaller W. , Jennings P. , Joannidis M.
Cell. Physiol. Biochem.26:311-318(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
11.

"Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expression."
Zaucke F. , Boehnlein J.M. , Steffens S. , Polishchuk R.S. , Rampoldi L. , Fischer A. , Pasch A. , Boehm C.W. , Baasner A. , Attanasio M. , Hoppe B. , Hopfer H. , Beck B.B. , Sayer J.A. , Hildebrandt F. , Wolf M.T.
Hum. Mol. Genet.19:1985-1997(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
12.

"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Halim A. , Nilsson J. , Ruetschi U. , Hesse C. , Larson G.
Mol. Cell. Proteomics0:0-0(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-232; ASN-322 AND ASN-396;STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY
13.

"Novel uromodulin mutation in familial juvenile hyperuricemic nephropathy."
Wei X. , Xu R. , Yang Z. , Li Z. , Liao Y. , Johnson R.J. , Yu X. , Chen W.
Am. J. Nephrol.36:114-120(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INVOLVEMENT IN HNFJ1
14.

"Renal manifestations of a mutation in the uromodulin (Tamm Horsfall protein) gene."
Bleyer A.J. , Trachtman H. , Sandhu J. , Gorry M.C. , Hart T.C.
Am. J. Kidney Dis.42:E20-E26(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HNFJ1 TYR-223
15.

"Allelism of MCKD, FJHN and GCKD caused by impairment of uromodulin export dynamics."
Rampoldi L. , Caridi G. , Santon D. , Boaretto F. , Bernascone I. , Lamorte G. , Tardanico R. , Dagnino M. , Colussi G. , Scolari F. , Ghiggeri G.M. , Amoroso A. , Casari G.
Hum. Mol. Genet.12:3369-3384(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MCKD2/HNFJ1 TRP-148; SER-150 AND TYR-317;VARIANT GCKDHI ARG-315;CHARACTERIZATION OF VARIANTS MCKD2/HNFJ1 TRP-148; SER-150 AND TYR-317;CHARACTERIZATION OF VARIANT GCKDHI ARG-315
16.

"UROMODULIN mutations cause familial juvenile hyperuricemic nephropathy."
Turner J.J.O. , Stacey J.M. , Harding B. , Kotanko P. , Lhotta K. , Puig J.G. , Roberts I. , Torres R.J. , Thakker R.V.
J. Clin. Endocrinol. Metab.88:1398-1401(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HNFJ1 TYR-77; ARG-126; SER-128; TYR-255 AND GLY-300
17.

"Mutations of the Uromodulin gene in MCKD type 2 patients cluster in exon 4, which encodes three EGF-like domains."
Wolf M.T.F. , Mucha B.E. , Attanasio M. , Zalewski I. , Karle S.M. , Neumann H.P.H. , Rahman N. , Bader B. , Baldamus C.A. , Otto E. , Witzgall R. , Fuchshuber A. , Hildebrandt F.
Kidney Int.64:1580-1587(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MCKD2 93-VAL--GLY-97 DELINS ALA-ALA-SER-CYS; LYS-225 AND TRP-248
18.

"A case of familial juvenile hyperuricemic nephropathy with novel uromodulin gene mutation, a novel heterozygous missense mutation in Korea."
Lee D.H. , Kim J.K. , Oh S.E. , Noh J.W. , Lee Y.K.
J. Korean Med. Sci.25:1680-1682(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HNFJ1 GLU-461
19.

"A Japanese family suffering from familial juvenile hyperuricemic nephropathy due to a rare mutation of the uromodulin gene."
Nakayama M. , Mori Y. , Ota N. , Ishida M. , Shiotsu Y. , Matsuoka E. , Kado H. , Ishida R. , Nakata M. , Kitani T. , Tamagaki K. , Sekita C. , Taniguchi A.
Case Rep. Nephrol. Urol.2:15-19(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HNFJ1 ARG-230
20.

"Novel UMOD mutations in familial juvenile hyperuricemic nephropathy lead to abnormal uromodulin intracellular trafficking."
Liu M. , Chen Y. , Liang Y. , Liu Y. , Wang S. , Hou P. , Zhang H. , Zhao M.
Gene531:363-369(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HNFJ1 GLU-109; GLN-236 AND TRP-248;CHARACTERIZATION OF VARIANTS HNFJ1 GLU-109; GLN-236 AND TRP-248;SUBCELLULAR LOCATION;TISSUE SPECIFICITY

Product Feedback Wall

* Email:
*Comments: