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Index > Protein center > VAV3(Gene name) > Human
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  • VAV3 (Gene name),
  • Guanine nucleotide exchange factor VAV3 (Protein name ),  VAV3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    VAV3;
    Protein name:
    Guanine nucleotide exchange factor VAV3(VAV-3);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with the PH domain of APS. Interacts (via SH2 domains) with the phosphorylated form of EPHA2.
    Function:
    Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitement by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    847
    Sequence:
    50:
    MEPWKQCAQW | LIHCKVLPTN | HRVTWDSAQV | FDLAQTLRDG | VLLCQLLNNL | 
    100:
    RAHSINLKEI | NLRPQMSQFL | CLKNIRTFLT | ACCETFGMRK | SELFEAFDLF | 
    150:
    DVRDFGKVIE | TLSRLSRTPI | ALATGIRPFP | TEESINDEDI | YKGLPDLIDE | 
    200:
    TLVEDEEDLY | DCVYGEDEGG | EVYEDLMKAE | EAHQPKCPEN | DIRSCCLAEI | 
    250:
    KQTEEKYTET | LESIEKYFMA | PLKRFLTAAE | FDSVFINIPE | LVKLHRNLMQ | 
    300:
    EIHDSIVNKN | DQNLYQVFIN | YKERLVIYGQ | YCSGVESAIS | SLDYISKTKE | 
    350:
    DVKLKLEECS | KRANNGKFTL | RDLLVVPMQR | VLKYHLLLQE | LVKHTTDPTE | 
    400:
    KANLKLALDA | MKDLAQYVNE | VKRDNETLRE | IKQFQLSIEN | LNQPVLLFGR | 
    450:
    PQGDGEIRIT | TLDKHTKQER | HIFLFDLAVI | VCKRKGDNYE | MKEIIDLQQY | 
    500:
    KIANNPTTDK | ENKKWSYGFY | LIHTQGQNGL | EFYCKTKDLK | KKWLEQFEMA | 
    550:
    LSNIRPDYAD | SNFHDFKMHT | FTRVTSCKVC | QMLLRGTFYQ | GYLCFKCGAR | 
    600:
    AHKECLGRVD | NCGRVNSGEQ | GTLKLPEKRT | NGLRRTPKQV | DPGLPKMQVI | 
    650:
    RNYSGTPPPA | LHEGPPLQLQ | AGDTVELLKG | DAHSLFWQGR | NLASGEVGFF | 
    700:
    PSDAVKPCPC | VPKPVDYSCQ | PWYAGAMERL | QAETELINRV | NSTYLVRHRT | 
    750:
    KESGEYAISI | KYNNEAKHIK | ILTRDGFFHI | AENRKFKSLM | ELVEYYKHHS | 
    800:
    LKEGFRTLDT | TLQFPYKEPE | HSAGQRGNRA | GNSLLSPKVL | GIAIARYDFC | 
    847:
    ARDMRELSLL | KGDVVKIYTK | MSANGWWRGE | VNGRVGWFPS | TYVEEDE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    UniGene:
    SMR:
    KEGG:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human VAV-3
    Cat.:
    E0219h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human VAV-3
    Cat.:
    E0219m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human VAV-3
    Cat.:
    U0219h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human VAV-3
    Cat.:
    U0219m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human VAV-3
    Cat.:
    P0219Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human VAV-3
    Cat.:
    P0219Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human VAV-3
    Monoclonal Antibody for Human VAV-3
    Protein for Human VAV-3
    Protein for Human VAV-3

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Non-stoichiometric reduced complexity probes for cDNA arrays."
      Trenkle T. , Welsh J. , Jung B. , Mathieu-Daude F. , McClelland M.
      Nucleic Acids Res.26:3883-3891(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [MRNA] OF 1-692 (ISOFORM 3);ALTERNATIVE PROMOTER USAGE;TISSUE SPECIFICITY;INDUCTION;VARIANT SER-298
      tissue: Keratinocyte.
    2. 2.
      "Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins."
      Movilla N. , Bustelo X.R.
      Mol. Cell. Biol.19:7870-7885(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);ALTERNATIVE SPLICING
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Trachea.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);VARIANT SER-298
    7. 7.
      "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation."
      Zeng L. , Sachdev P. , Yan L. , Chan J.L. , Trenkle T. , McClelland M. , Welsh J. , Wang L.H.
      Mol. Cell. Biol.20:9212-9224(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ROS1;PHOSPHORYLATION;TISSUE SPECIFICITY
    8. 8.
      "Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity."
      Yabana N. , Shibuya M.
      Oncogene21:7720-7729(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APS
    9. 9.
      "Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis."
      Hunter S.G. , Zhuang G. , Brantley-Sieders D.M. , Swat W. , Cowan C.W. , Chen J.
      Mol. Cell. Biol.26:4830-4842(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPHA2
    10. 10.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-141;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    11. 11.
      "Solution structure of the CH domain from human VAV-3 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2006-12) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-134
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