VDAC1 ELISA Kit for Human(Homo sapiens) | EIAab.comVDAC1 ELISA Kit for Human(Homo sapiens)

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VDAC1 (Gene name),

Voltage-dependent anion-selective channel protein 1 (Protein name ), VDAC1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

VDAC1(VDAC);

Protein name:

Voltage-dependent anion-selective channel protein 1(VDAC-1;hVDAC1);

Alternative:

Plasmalemmal porin;Outer mitochondrial membrane protein porin 1;Porin 31HM;Porin 31HL;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with hexokinases (By similarity). Interacts with BCL2L1. Interacts with influenza A virus PB1-F2 protein.

Function:

Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

Subcellular Location:

Mitochondrion outer membrane Cell membrane

Protein Attributes:

Sequence length:

283

Sequence:

50:

100:

150:

200:

250:

283:

LKPGIKLTLS | ALLDGKNVNA | GGHKLGLGLE | FQA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P21796

MIM:

604492

Pfam:

PF01459

KEGG:

hsa:7416

UniGene:

Hs.519320

STRING:

9606.ENSP00000265333

String:

P21796

Uniprot:

P21796

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ELISA Kit for Human VDAC-1

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ELISA Kit for Human VDAC-1

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E12942h

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ELISA Kit for Human VDAC-1

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E12942r

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ELISA Kit for Human VDAC-1

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E12942m

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ELISA Kit for Human VDAC-1

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E12942b

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ELISA Kit for Human VDAC-1

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E12942p

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96T

CLIA Kit for Human VDAC-1

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U12942m

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96T

CLIA Kit for Human VDAC-1

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U12942r

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96T

CLIA Kit for Human VDAC-1

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U12942h

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96T

CLIA Kit for Human VDAC-1

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U12942p

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CLIA Kit for Human VDAC-1

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CLIA Kit for Human VDAC-1

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U12942b

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Polyclonal Antibody for Human VDAC-1

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P12942Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human VDAC-1

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P12942Rb-m

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Polyclonal Antibody for Human VDAC-1

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P12942Rb-r

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Monoclonal Antibody for Human VDAC-1

Protein for Human VDAC-1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Cloning and functional expression in yeast of two human isoforms of the outer mitochondrial membrane channel, the voltage-dependent anion channel."
Blachly-Dyson E. , Zambronicz E.B. , Yu W.H. , Adams V. , McCabe E.R. , Adelman J.P. , Colombini M. , Forte M.A.
J. Biol. Chem.268:1835-1841(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Cloning of human VDAC cDNA."
Blachly-Dyson E. , Forte M.A.
Biophys. J.59:216A-216A(1991)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Pituitary.
3.

"Revised fine mapping of the human voltage-dependent anion channel loci by radiation hybrid analysis."
Decker W.K. , Bowles K.R. , Schatte E.C. , Towbin J.A. , Craigen W.J.
Mamm. Genome10:1041-1042(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Characterization of the human porin isoform 1 (HVDAC1) gene by amplification on the whole human genome: a tool for porin deficiency analysis."
Messina A. , Guarino F. , Oliva M. , van den Heuvel L.P. , Smeitink J. , De Pinto V.
Biochem. Biophys. Res. Commun.270:787-792(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Thymus.
6.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
tissue: Skin.
9.

"Identification of human porins. II. Characterization and primary structure of a 31-lDa porin from human B lymphocytes (Porin 31HL)."
Kayser H. , Kratzin H.D. , Thinnes F.P. , Goetz H. , Schmidt W.E. , Eckart K. , Hilschmann N.
Biol. Chem. Hoppe-Seyler370:1265-1278(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-283
tissue: Lymphocyte.
10.

"Studies on human porin. IV. The primary structures of 'Porin 31HM' purified from human skeletal muscle membranes and of 'Porin 31HL' derived from human B lymphocyte membranes are identical."
Juergens L. , Ilsemann P. , Kratzin H.D. , Hesse D. , Eckart K. , Thinnes F.P. , Hilschmann N.
Biol. Chem. Hoppe-Seyler372:455-463(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-283
tissue: Skeletal muscle.
11.

Hein A. , Kiafard Z. , Hesse D. , Hesse J.-O. , Zimmermann B. , Kratzin H.D. , Schulz H. , Reiss J. , Thinnes F.P. , Goetz H. , Hilschmann N.
Submitted (1997-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-283
tissue: B-cell.
12.

Bienvenut W.V.
Submitted (2005-03) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-12; 21-61; 64-74; 94-110; 121-139; 162-174; 225-236 AND 257-274;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: B-cell lymphoma.
13.

Lubec G. , Vishwanath V. , Chen W.-Q. , Sun Y.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 75-93; 175-197 AND 201-218;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Brain.
tissue: Cajal-Retzius cell.
tissue: Fetal brain cortex.
14.

"Mapping of residues forming the voltage sensor of the voltage-dependent anion-selective channel."
Thomas L. , Blachly-Dyson E. , Colombini M. , Forte M.A.
Proc. Natl. Acad. Sci. U.S.A.90:5446-5449(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
15.

"Subcellular localization of human voltage-dependent anion channel isoforms."
Yu W.H. , Wolfgang W. , Forte M.A.
J. Biol. Chem.270:13998-14006(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
16.

"Mitochondria-derived and extra-mitochondrial human type-1 porin are identical as revealed by amino acid sequencing and electrophysiological characterisation."
Stadtmueller U. , Eben-Brunnen J. , Schmid A. , Hesse D. , Klebert S. , Kratzin H.D. , Hesse J. , Zimmermann B. , Reymann S. , Thinnes F.P. , Benz R. , Goetz H. , Hilschmann N.
Biol. Chem.380:1461-1466(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;PARTIAL PROTEIN SEQUENCE
17.

"Gadolinium as an opener of the outwardly rectifying Cl(-) channel (ORCC). Is there relevance for cystic fibrosis therapy?"
Thinnes F.P. , Walter G. , Hellmann K.P. , Hellmann T. , Merker R. , Kiafard Z. , Eben-Brunnen J. , Schwarzer C. , Goetz H. , Hilschmann N.
Pflugers Arch.443:S111-S116(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
18.

"Study of PTPC composition during apoptosis for identification of viral protein target."
Verrier F. , Mignotte B. , Jan G. , Brenner C.
Ann. N. Y. Acad. Sci.1010:126-142(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS
19.

"Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1."
Zamarin D. , Garcia-Sastre A. , Xiao X. , Wang R. , Palese P.
PLoS Pathog.1:40-54(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INFLUENZA A VIRUS PB1-F2
20.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
21.

"Phosphoproteome of resting human platelets."
Zahedi R.P. , Lewandrowski U. , Wiesner J. , Wortelkamp S. , Moebius J. , Schuetz C. , Walter U. , Gambaryan S. , Sickmann A.
J. Proteome Res.7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Platelet.
22.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
23.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
24.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
25.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-20 AND LYS-266;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.

"Phosphorylation by Nek1 regulates opening and closing of voltage dependent anion channel 1."
Chen Y. , Gaczynska M. , Osmulski P. , Polci R. , Riley D.J.
Biochem. Biophys. Res. Commun.394:798-803(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-193;MUTAGENESIS OF SER-193
27.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
28.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
29.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
30.

"PKCepsilon promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria."
Lau E. , Kluger H. , Varsano T. , Lee K. , Scheffler I. , Rimm D.L. , Ideker T. , Ronai Z.A.
Cell148:543-555(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATF2 AND HK1
31.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
32.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
33.

"Human Bop is a novel BH3-only member of the Bcl-2 protein family."
Zhang X. , Weng C. , Li Y. , Wang X. , Jiang C. , Li X. , Xu Y. , Chen Q. , Pan L. , Tang H.
Protein Cell3:790-801(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BOP/C22ORF29
34.

"Structure of the human voltage-dependent anion channel."
Bayrhuber M. , Meins T. , Habeck M. , Becker S. , Giller K. , Villinger S. , Vonrhein C. , Griesinger C. , Zweckstetter M. , Zeth K.
Proc. Natl. Acad. Sci. U.S.A.105:15370-15375(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (4.1 ANGSTROMS) OF 2-283;STRUCTURE BY NMR
35.

"Solution structure of the integral human membrane protein VDAC-1 in detergent micelles."
Hiller S. , Garces R.G. , Malia T.J. , Orekhov V.Y. , Colombini M. , Wagner G.
Science321:1206-1210(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR;FUNCTION;INTERACTION WITH BCL2L1;NADH-BINDING

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