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Index > Protein center > Vdac1(Gene name) > Mouse
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  • Vdac1 (Gene name),
  • Voltage-dependent anion-selective channel protein 1 (Protein name ),  VDAC1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    Vdac1(Vdac5);
    Protein name:
    Voltage-dependent anion-selective channel protein 1(VDAC-1;mVDAC1);
    Alternative:
    Plasmalemmal porin;Outer mitochondrial membrane protein porin 1;Voltage-dependent anion-selective channel protein 5(VDAC-5;mVDAC5);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with hexokinases (By similarity). Interacts with BCL2L1.
    Function:
    Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
    Subcellular Location:
    Isoform Pl-VDAC1 Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    296
    Sequence:
    50:
    MCSFFLVLLL | WQNMAVPPTY | ADLGKSARDV | FTKGYGFGLI | KLDLKTKSEN | 
    100:
    GLEFTSSGSA | NTETTKVNGS | LETKYRWTEY | GLTFTEKWNT | DNTLGTEITV | 
    150:
    EDQLARGLKL | TFDSSFSPNT | GKKNAKIKTG | YKREHINLGC | DVDFDIAGPS | 
    200:
    IRGALVLGYE | GWLAGYQMNF | ETSKSRVTQS | NFAVGYKTDE | FQLHTNVNDG | 
    250:
    TEFGGSIYQK | VNKKLETAVN | LAWTAGNSNT | RFGIAAKYQV | DPDACFSAKV | 
    296:
    NNSSLIGLGY | TQTLKPGIKL | TLSALLDGKN | VNAGGHKLGL | GLEFQA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    UniGene:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse VDAC-1
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    Polyclonal Antibody for Mouse VDAC-1
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    Monoclonal Antibody for Mouse VDAC-1
    Monoclonal Antibody for Mouse VDAC-1
    Monoclonal Antibody for Mouse VDAC-1
    Monoclonal Antibody for Mouse VDAC-1
    Monoclonal Antibody for Mouse VDAC-1
    Monoclonal Antibody for Mouse VDAC-1
    Protein for Mouse VDAC-1
    Protein for Mouse VDAC-1
    Protein for Mouse VDAC-1
    Protein for Mouse VDAC-1
    Protein for Mouse VDAC-1
    Protein for Mouse VDAC-1

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    References
    1. 1.
      "Isolation, characterization, and mapping of two mouse mitochondrial voltage-dependent anion channel isoforms."
      Sampson M.J. , Lovell R.S. , Craigen W.J.
      Genomics33:283-288(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM MT-VDAC1);TISSUE SPECIFICITY
      tissue: Brain.
    2. 2.
      "Evidence for secretory pathway localization of a voltage-dependent anion channel isoform."
      Buettner R. , Papoutsoglou G. , Scemes E. , Spray D.C. , Dermietzel R.
      Proc. Natl. Acad. Sci. U.S.A.97:3201-3206(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS MT-VDAC1 AND PL-VDAC1);FUNCTION;SUBCELLULAR LOCATION
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM MT-VDAC1)
      strain: C57BL/6J.
      strain: NOD.
      tissue: Amnion.
      tissue: Embryonic kidney.
      tissue: Embryonic stomach.
      tissue: Thymus.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM MT-VDAC1)
      strain: FVB/N.
      tissue: Liver.
    6. 6.
      Lubec G. , Klug S. , Kang S.U. , Sunyer B. , Chen W.-Q.
      Submitted (2009-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 34-41; 46-66; 77-106; 110-123; 134-174; 177-210; 214-231; 238-279 AND 288-296;IDENTIFICATION BY MASS SPECTROMETRY
      strain: C57BL/6.
      strain: OF1.
      tissue: Brain.
      tissue: Hippocampus.
    7. 7.
      "Voltage-dependent anion channel-1 (VDAC-1) contributes to ATP release and cell volume regulation in murine cells."
      Okada S.F. , O'Neal W.K. , Huang P. , Nicholas R.A. , Ostrowski L.E. , Craigen W.J. , Lazarowski E.R. , Boucher R.C.
      J. Gen. Physiol.124:513-526(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
      J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-80;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    9. 9.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-33;SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-33;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
      tissue: Liver.
    10. 10.
      "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J. , Newman J.C. , Held J.M. , Cusack M.P. , Sorensen D.J. , Li B. , Schilling B. , Mooney S.D. , Kahn C.R. , Verdin E. , Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A.110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-33; LYS-122 AND LYS-265;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    11. 11.
      "The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating."
      Ujwal R. , Cascio D. , Colletier J.-P. , Faham S. , Zhang J. , Toro L. , Ping P. , Abramson J.
      Proc. Natl. Acad. Sci. U.S.A.105:17742-17747(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 14-296;FUNCTION;TOPOLOGY
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