Protein name:
Partner of Y14 and mago ;
Alternative:
Protein wibg homolog ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Interacts (via N-terminus) with MAGOH and RBM8A; the interaction is direct. Associates (eIF2A-like region) with the 40S ribosomal subunit and the 48S preinitiation complex.
Function:
Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions.
Subcellular Location:
Cytoplasm
Nucleus
nucleolus
Nucleus
nucleoplasm
Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by XPO1/CRM1.
Protein Attributes:
50:
MATPYVTDET | GGKYIASTQR | PDGTWRKQRR | VKEGYVPQEE | VPVYENKYVK |
100:
FFKSKPELPP | GLSPEATAPI | TASRPEGGEP | ALSKTAKRNL | KRKEKRRQQQ |
150:
EKGEAEALSR | TLEKVSLGET | AQVPSAPQAS | RAAPTAASDQ | PDSAATTEKA |
200:
KKIKNLKKKL | RQVEELQQRI | QAGEISQPSK | EQLEKLARRR | ALEEELEDLE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Mouse
ELISA Kit for Bovine Partner of Y14 and mago
ELISA Kit for Bovine Partner of Y14 and mago
ELISA Kit for Bovine Partner of Y14 and mago
CLIA Kit for Bovine Partner of Y14 and mago
CLIA Kit for Bovine Partner of Y14 and mago
CLIA Kit for Bovine Partner of Y14 and mago
Polyclonal Antibody for Bovine Partner of Y14 and mago
Polyclonal Antibody for Bovine Partner of Y14 and mago
Polyclonal Antibody for Bovine Partner of Y14 and mago
Monoclonal Antibody for Bovine Partner of Y14 and mago
Monoclonal Antibody for Bovine Partner of Y14 and mago
Monoclonal Antibody for Bovine Partner of Y14 and mago
Protein for Bovine Partner of Y14 and mago
Protein for Bovine Partner of Y14 and mago
Protein for Bovine Partner of Y14 and mago
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Hereford .
tissue :
Fetal liver .