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Index > Protein center > XBP1(Gene name) > Human
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  • XBP1 (Gene name),
  • X-box-binding protein 1 (Protein name ),  XBP1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    XBP1(TREB5;XBP2);
    Protein name:
    X-box-binding protein 1(XBP-1);
    Alternative:
    Tax-responsive element-binding protein 5;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    261
    Sequence:
    50:
    MVVVAAAPNP | ADGTPKVLLL | SGQPASAAGA | PAGQALPLMV | PAQRGASPEA | 
    100:
    ASGGLPQARK | RQRLTHLSPE | EKALRRKLKN | RVAAQTARDR | KKARMSELEQ | 
    150:
    QVVDLEEENQ | KLLLENQLLR | EKTHGLVVEN | QELRQRLGMD | ALVAEEEAEA | 
    200:
    KGNEVRPVAG | SAESAALRLR | APLQQVQAQL | SPLQNISPWI | LAVLTLQIQS | 
    250:
    LISCWAFWTT | WTQSCSSNAL | PQSLPAWRSS | QRSTQKDPVP | YQPPFLCQWG | 
    261:
    RHQPSWKPLM | N
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    UniGene:
    Pfam:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human XBP-1
    Cat.:
    E9143h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human XBP-1
    Cat.:
    E9143m
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human XBP-1
    Cat.:
    E9143r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human XBP-1
    Cat.:
    E9143b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human XBP-1
    Cat.:
    U9143r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human XBP-1
    Cat.:
    U9143h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human XBP-1
    Cat.:
    U9143b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human XBP-1
    Cat.:
    U9143m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human XBP-1
    Cat.:
    P9143Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human XBP-1
    Cat.:
    P9143Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human XBP-1
    Polyclonal Antibody for Human XBP-1
    Monoclonal Antibody for Human XBP-1
    Monoclonal Antibody for Human XBP-1
    Monoclonal Antibody for Human XBP-1
    Monoclonal Antibody for Human XBP-1
    Protein for Human XBP-1
    Protein for Human XBP-1
    Protein for Human XBP-1
    Protein for Human XBP-1

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    Linearity
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    References
    1. 1.
      "A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter."
      Liou H.-C. , Boothby M.R. , Finn P.W. , Davidon R. , Nabavi N. , Zeleznik-Le N.J. , Ting J.P.-Y. , Glimcher L.H.
      Science247:1581-1584(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
    2. 2.
      "Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain."
      Yoshimura T. , Fujisawa J. , Yoshida M.
      EMBO J.9:2537-2542(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
    3. 3.
      "The regulatory gene, hXBP-1, and its target, HLA-DRA, utilize both common and distinct regulatory elements and protein complexes."
      Ponath P.D. , Fass D. , Liou H.C. , Glimcher L.H. , Strominger J.L.
      J. Biol. Chem.268:17074-17082(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];FUNCTION
    4. 4.
      "XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor."
      Yoshida H. , Matsui T. , Yamamoto A. , Okada T. , Mori K.
      Cell107:881-891(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);INDUCTION;FUNCTION
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Ovary.
      tissue: Placenta.
    8. 8.
      "The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core."
      Clauss I.M. , Chu M. , Zhao J.-L. , Glimcher L.H.
      Nucleic Acids Res.24:1855-1864(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder."
      Kakiuchi C. , Iwamoto K. , Ishiwata M. , Bundo M. , Kasahara T. , Kusumi I. , Tsujita T. , Okazaki Y. , Nanko S. , Kunugi H. , Sasaki T. , Kato T.
      Nat. Genet.35:171-175(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO MAJOR AFFECTIVE DISORDER TYPE 7
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-12
    11. 11.
      "Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas."
      Chanock S.J. , Burdett L. , Yeager M. , Llaca V. , Langeroed A. , Presswalla S. , Kaaresen R. , Strausberg R.L. , Gerhard D.S. , Kristensen V. , Perou C.M. , Boerresen-Dale A.-L.
      Breast Cancer Res.9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LYS-232
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