Language:
  
[Sign in] [Register]   

EIAab logo

EIAab news detail, please contact eiaab@eiaab.com if you have any questions about online orders and payment.
Improvement of high-fat diet-induced obesity by a mixture of red grape extract, soy isoflavone and l-carnitine: Implications in cardiovascular and...
Update time:2018-11-09 09:35:00   【 Font: Large  Medium Small

Improvement of high-fat diet-induced obesity by a mixture of red grape extract, soy isoflavone and L-carnitine: implications in cardiovascular and non-alcoholic fatty liver diseases

Abstract

In the present study, we examined the effect of a mixture of dietary components, including red grape 28 extract, soy isoflavone and L-carnitine (RISC), on obesity. RISC substantially inhibited high-fat diet 29 (HFD)-induced increase in body weight in a dose-dependent manner in C57BL/6 mice. The amount of 30 subcutaneous and mesenteric fat was also significantly decreased by RISC treatment in HFD-fed 31 C57BL/6 mice, whereas epididymal fat was not affected. Moreover, HFD-induced plasma leptin levels 32 were down-regulated by RISC treatment. In these mice, RISC treatment significantly increased the plasma 33 level of high density lipoprotein cholesterol without affecting the level of low density lipoprotein choles- 34 terol and triglycerides. In addition, HFD-induced increase in liver weight and lipid accumulation in liver 35 was significantly suppressed by RISC treatment in C57BL/6 mice. Plasma level of glutamic-oxaloacetic 36 transaminase and glutamic-pyruvic transaminase was also inhibited by RISC treatment. These results 37 demonstrate that RISC suppresses HFD-induced obesity and suggest that RISC supplementation might 38 be a promising adjuvant therapy for the treatment of obesity and its complications, such as cardiovascu- 39 lar and non-alcoholic fatty liver diseases. 

Cited products
Source:Food Chem Toxicol      by Jong Soon Kang, Won Kyung Lee, Chang Woo Lee, Won Kee Yoon, Nayang Kim, Sang-Ki Park, Heon-Sik Lee, Hyoung Kook Park, Sang-Bae Han, Jieun Yun, Kiho Lee, Ki Hoon Lee, Song-Kyu Park, , , Hwan Mook Kim
Hot Genes
ALCAM ACE KSR2 ASPRO C19orf80 Gdf5 Trap1a Atf2
Top Searches
Ubiquitin-protein ligase Ubiquitin ELISA metalloproteinase Asprosin Tumor necrosis TRAP1A vitamin d
Why choose EIAAB
Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
Further Information
About us Protein center Bank account Distributors Terms & Conditions Career eiaab.cn

Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

Twitter