[Sign in] [Register]   

EIAab logo

EIAab news detail, please contact if you have any questions about online orders and payment.
Apelin in Plasma and Vitreous and in Fibrovascular Retinal Membranes of Patients with Proliferative Diabetic Retinopathy
Update time:2018-11-08 00:49:46   【 Font: Large  Medium Small

PURPOSE. Apelin is an endogenous ligand for the angiotensin-1-like receptor APJ. Because apelin has been reported to regulate angiogenesis, the authors searched for associations between apelin and proliferative diabetic retinopathy.

METHODS. The study included 55 patients undergoing vitrectomy for proliferative diabetic retinopathy (study group) and 34 patients undergoing vitrectomy for idiopathic preretinal membranes or macular hole (control group). Using enzymelinked immunosorbent assay, the authors measured the concentrations of apelin and vascular endothelial growth factor(VEGF) in the vitreous and plasma. The expression of apelin and angiotensin-1-like receptor APJ in the excised membranes was examined by fluorescence immunostaining and semiquantitative reverse transcription polymerase chain reaction.

RESULTS. Vitreous concentrations of apelin were significantly higher in the study group than in the control group (P 0.005), whereas plasma concentrations of apelin did not vary significantly (P  0.66). The vitreous concentrations (P 0.001) and the plasma concentrations (P  0.03) of VEGF were significantly higher in the study group than in the control group. Neither the vitreous concentrations of apelin and VEGF (P  0.47) nor the plasma concentrations of apelin and VEGF (P  0.19) were significantly associated with each other. In the fibrovascular membranes of the study group, colocalization of the endothelial markers CD31 with the markers for apelin and colocalization of the endothelial markers CD31 and APJ was observed. Expression of apelin mRNA (P  0.03), APJ mRNA

Cited products
Source:Invest Ophthalmol Vis Sci      by Yong Tao, Qiang Lu, Yan-Rong Jiang, Jing Qian, Jia-Yan Wang, Lei Gao, and Jost B. Jonas
Hot Genes
ALCAM ACE KSR2 ASPRO C19orf80 Gdf5 Trap1a Atf2
Top Searches
Ubiquitin ELISA Ubiquitin-protein ligase metalloproteinase Asprosin Tumor necrosis TRAP1A vitamin d
Why choose EIAAB
Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
Further Information
About us Protein center Bank account Distributors Terms & Conditions Career

Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab