Abstract: Cadmium (Cd) is a potent neurotoxic heavy metal, which induces oxidative stress and membrane
disturbances in brain. The present study investigate the possible neuroprotective efficacy of Spirulina platensis (Sp) against CdCl induced changes in the plasma neurochemistry of catecholamine (adrenaline, nor adrenaline, dopamine), serotonin, gamma amino-butyric acid (GABA), activity of acetyl cholinesterase (AChE), DNA fragmentation of the brain cells and the histopathology of the brain tissue in rats. Animals were divided
into five groups. Gp.(1) Control, gp.(2) CdCl (2mg/kg bwt) S/C injection, gp.(3) Spirulina (150 mg/kg bwt) 2
orally, gp(4) Co-treated with both CdCl and Sp and gp.(5) Administered CdCl (2mg/kg bwt), in all gps the 2 2
treatment is day after day for 30 days except gp.(5) post- treated by Sp for another 30 days. The results
indicated that cadmium induce oxidative stress in the brain leading to alterations in the plasma neurochemistry
and increase the DNA fragmentation of the brain tissue, Spirulina platensis given incombination and
post-treatment with Cd significantly reduces pathological alterations in plasma neurochemistry, decrease the
degree of DNA fragmentation of the brain cells and capable of reducing the pathological damage of the brain
tissue. We concluded that S.platensis can significantly modify the brain damages against cadmium chloride
induced toxicity.