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Index > Protein center > IL6ST(Gene name) > Human
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  • IL6ST (Gene name),
  • Interleukin-6 receptor subunit beta (Protein name ),  IL6RB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (1)
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  • Gene name:
    IL6ST;
    Protein name:
    Interleukin-6 receptor subunit beta(IL-6 receptor subunit beta;IL-6R subunit beta;IL-6R-beta;IL-6RB);
    Alternative:
    Oncostatin-M receptor subunit alpha;Membrane glycoprotein 130(gp130);CDw130;Interleukin-6 signal transducer;
    CD:
    CD130;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with INPP5D/SHIP1 (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer binds two molecules of herpes virus IL6. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST.
    Function:
    Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.
    Subcellular Location:
    Isoform 2 Secreted
    Protein Attributes:
    Sequence length:
    918
    Sequence:
    50:
    MLTLQTWLVQ | ALFIFLTTES | TGELLDPCGY | ISPESPVVQL | HSNFTAVCVL | 
    100:
    KEKCMDYFHV | NANYIVWKTN | HFTIPKEQYT | IINRTASSVT | FTDIASLNIQ | 
    150:
    LTCNILTFGQ | LEQNVYGITI | ISGLPPEKPK | NLSCIVNEGK | KMRCEWDGGR | 
    200:
    ETHLETNFTL | KSEWATHKFA | DCKAKRDTPT | SCTVDYSTVY | FVNIEVWVEA | 
    250:
    ENALGKVTSD | HINFDPVYKV | KPNPPHNLSV | INSEELSSIL | KLTWTNPSIK | 
    300:
    SVIILKYNIQ | YRTKDASTWS | QIPPEDTAST | RSSFTVQDLK | PFTEYVFRIR | 
    350:
    CMKEDGKGYW | SDWSEEASGI | TYEDRPSKAP | SFWYKIDPSH | TQGYRTVQLV | 
    400:
    WKTLPPFEAN | GKILDYEVTL | TRWKSHLQNY | TVNATKLTVN | LTNDRYLATL | 
    450:
    TVRNLVGKSD | AAVLTIPACD | FQATHPVMDL | KAFPKDNMLW | VEWTTPRESV | 
    500:
    KKYILEWCVL | SDKAPCITDW | QQEDGTVHRT | YLRGNLAESK | CYLITVTPVY | 
    550:
    ADGPGSPESI | KAYLKQAPPS | KGPTVRTKKV | GKNEAVLEWD | QLPVDVQNGF | 
    600:
    IRNYTIFYRT | IIGNETAVNV | DSSHTEYTLS | SLTSDTLYMV | RMAAYTDEGG | 
    650:
    KDGPEFTFTT | PKFAQGEIEA | IVVPVCLAFL | LTTLLGVLFC | FNKRDLIKKH | 
    700:
    IWPNVPDPSK | SHIAQWSPHT | PPRHNFNSKD | QMYSDGNFTD | VSVVEIEAND | 
    750:
    KKPFPEDLKS | LDLFKKEKIN | TEGHSSGIGG | SSCMSSSRPS | ISSSDENESS | 
    800:
    QNTSSTVQYS | TVVHSGYRHQ | VPSVQVFSRS | ESTQPLLDSE | ERPEDLQLVD | 
    850:
    HVDGGDGILP | RQQYFKQNCS | QHESSPDISH | FERSKQVSSV | NEEDFVRLKQ | 
    900:
    QISDHISQSC | GSGQMKMFQE | VSAADAFGPG | TEGQVERFET | VGMEAATDEG | 
    918:
    MPKSYLPQTV | RQGGYMPQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    Pfam:
    String:
    UniGene:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human IL-6 receptor subunit beta
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    CLIA Kit for Human IL-6 receptor subunit beta
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    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human IL-6 receptor subunit beta
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    P0046Rb-m
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    Polyclonal Antibody for Human IL-6 receptor subunit beta
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    Polyclonal Antibody for Human IL-6 receptor subunit beta
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    P0046Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human IL-6 receptor subunit beta
    Monoclonal Antibody for Human IL-6 receptor subunit beta
    Monoclonal Antibody for Human IL-6 receptor subunit beta
    Protein for Human IL-6 receptor subunit beta
    Protein for Human IL-6 receptor subunit beta
    Protein for Human IL-6 receptor subunit beta

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    References
    1. 1.
      "Molecular cloning and expression of an IL-6 signal transducer, gp130."
      Hibi M. , Murakami M. , Saito M. , Hirano T. , Taga T. , Kishimoto T.
      Cell63:1149-1157(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT VAL-8
      tissue: Myeloma.
      tissue: Placenta.
    2. 2.
      "Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis."
      Tanaka M. , Kishimura M. , Ozaki S. , Osakada F. , Hashimoto H. , Okubo M. , Murakami M. , Nakao K.
      J. Clin. Invest.106:137-144(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT VAL-8
      tissue: Synovium.
    3. 3.
      "IL6ST mRNA, nirs splice variant 4."
      Hayashi A. , Sameshima E. , Tabata Y. , Iida K. , Mitsuyama M. , Kanai S. , Furuya T. , Saito T.
      Submitted (2003-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      "Determination of the disulfide structure and N-glycosylation sites of the extracellular domain of the human signal transducer gp130."
      Moritz R.L. , Hall N.E. , Connolly L.M. , Simpson R.J.
      J. Biol. Chem.276:8244-8253(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;DISULFIDE BONDS;GLYCOSYLATION AT ASN-43; ASN-83; ASN-131; ASN-157; ASN-227; ASN-379; ASN-383; ASN-553 AND ASN-564
    7. 8.
      "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation."
      Mosley B. , De Imus C. , Friend D. , Boiani N. , Thoma B. , Park L.S. , Cosman D.
      J. Biol. Chem.271:32635-32643(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;INDUCTION
    8. 9.
      "Signal transduction of interleukin-6 involves tyrosine phosphorylation of multiple cytosolic proteins and activation of Src-family kinases Fyn, Hck, and Lyn in multiple myeloma cell lines."
      Hallek M. , Neumann C. , Schaffer M. , Danhauser-Riedl S. , von Bubnoff N. , de Vos G. , Druker B.J. , Yasukawa K. , Griffin J.D. , Emmerich B.
      Exp. Hematol.25:1367-1377(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCK
    9. 10.
      "Phosphorylation of human gp130 at Ser-782 adjacent to the di-leucine internalization motif. Effects on expression and signaling."
      Gibson R.M. , Schiemann W.P. , Prichard L.B. , Reno J.M. , Ericsson L.H. , Nathanson N.M.
      J. Biol. Chem.275:22574-22582(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-782;MUTAGENESIS OF SER-782;IDENTIFICATION BY MASS SPECTROMETRY
    10. 11.
      "Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling."
      Li H. , Wang H. , Nicholas J.
      J. Virol.75:3325-3334(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HHV-8 PROTEIN VIL6
    11. 12.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-379 AND ASN-383
      tissue: Plasma.
    12. 13.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-829;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-667;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Platelet.
    14. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 16.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-227 AND ASN-390
      tissue: Liver.
    16. 17.
      "A strategy for precise and large scale identification of core fucosylated glycoproteins."
      Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
      Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-390
    17. 18.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-667;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 19.
      "Crystal structure of a cytokine-binding region of gp130."
      Bravo J. , Staunton D. , Heath J.K. , Jones E.Y.
      EMBO J.17:1665-1674(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 122-325
    19. 20.
      "Structure of an extracellular gp130 cytokine receptor signaling complex."
      Chow D.-C. , He X.-L. , Snow A.L. , Rose-John S. , Garcia K.C.
      Science291:2150-2155(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 23-325 IN COMPLEX WITH HERPES VIRUS IL6;SUBUNIT;GLYCOSYLATION
    20. 21.
      "Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130."
      Boulanger M.J. , Bankovich A.J. , Kortemme T. , Baker D. , Garcia K.C.
      Mol. Cell12:577-589(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 123-323 IN COMPLEX WITH LIF
    21. 22.
      "Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex."
      Boulanger M.J. , Chow D.-C. , Brevnova E.E. , Garcia K.C.
      Science300:2101-2104(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.65 ANGSTROMS) OF 23-321 IN COMPLEX WITH IL6 AND IL6R;SUBUNIT
    22. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-415
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