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Index > Protein center > C19orf80(Gene name) > Human
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  • C19orf80 (Gene name),
  • Betatrophin (Protein name ),  BETAT_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (46)
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  • Gene name:
    C19orf80(UNQ599/PRO1185;Angptl8);
    Protein name:
    Betatrophin;
    Alternative:
    Angiopoietin-like protein 8;Lipasin;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with ANGPTL3.
    Function:
    Hormone that specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. Promotes pancreatic beta cell proliferation without insulin resistance. Also acts as a blood lipid regulator by regulating serum triglyceride levels; possibly by promoting ANGPTL3 cleavage.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    198
    Sequence:
    50:
    MPVPALCLLW | ALAMVTRPAS | AAPMGGPELA | QHEELTLLFH | GTLQLGQALN | 
    100:
    GVYRTTEGRL | TKARNSLGLY | GRTIELLGQE | VSRGRDAAQE | LRASLLETQM | 
    150:
    EEDILQLQAE | ATAEVLGEVA | QAQKVLRDSV | QRLEVQLRSA | WLGPAYREFE | 
    198:
    VLKAHADKQS | HILWALTGHV | QRQRREMVAQ | QHRLRQIQER | LHTAALPA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Betatrophin
    Cat.:
    E11644h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Betatrophin
    Cat.:
    U11644h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Betatrophin
    Cat.:
    P11644Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Betatrophin
    Protein for Human Betatrophin
    Cat.:
    R11644h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%

    R&D Technical Data

     12% SDS-PAGE analysis

             12% SDS-PAGE analysis

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Citations
    References
    1. 1.
      "Identification of genes differentially expressed in human hepatocellular carcinoma by a modified suppression subtractive hybridization method."
      Dong X.Y. , Pang X.W. , Yu S.T. , Su Y.R. , Wang H.C. , Yin Y.H. , Wang Y.D. , Chen W.F.
      Int. J. Cancer112:239-248(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism."
      Ren G. , Kim J.Y. , Smas C.M.
      Am. J. Physiol.303:E334-E351(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;INDUCTION;DEVELOPMENTAL STAGE
    6. 6.
      "Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels."
      Zhang R.
      Biochem. Biophys. Res. Commun.424:786-792(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INDUCTION;INTERACTION WITH ANGPTL3;VARIANT TRP-59;CHARACTERIZATION OF VARIANT TRP-59
    8. 8.
      "Betatrophin: a hormone that controls pancreatic beta cell proliferation."
      Yi P. , Park J.S. , Melton D.A.
      Cell153:747-758(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    9. 9.
      "Perspectives on the activities of ANGPTL8/betatrophin."
      Yi P. , Park J.S. , Melton D.A.
      Cell159:467-468(2014)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN PANCREATIC BETA-CELLS PROLIFERATION
    10. 10.
      "ANGPTL8/betatrophin does not control pancreatic beta cell expansion."
      Gusarova V. , Alexa C.A. , Na A. , Stevis P.E. , Xin Y. , Bonner-Weir S. , Cohen J.C. , Hobbs H.H. , Murphy A.J. , Yancopoulos G.D. , Gromada J.
      Cell159:691-696(2014)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN PANCREATIC BETA-CELLS PROLIFERATION
    11. 11.
      "Increased circulating levels of betatrophin in newly diagnosed type 2 diabetic patients."
      Hu H. , Sun W. , Yu S. , Hong X. , Qian W. , Tang B. , Wang D. , Yang L. , Wang J. , Mao C. , Zhou L. , Yuan G.
      Diabetes Care37:2718-2722(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN NIDDM
    12. 12.
      "Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes."
      Espes D. , Lau J. , Carlsson P.O.
      Diabetologia57:50-53(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN IDDM
    13. 13.
      "An explanation for recent discrepancies in levels of human circulating betatrophin."
      Fu Z. , Abou-Samra A.B. , Zhang R.
      Diabetologia57:2232-2234(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
    14. 14.
      "Increased circulating betatrophin concentrations in patients with type 2 diabetes."
      Espes D. , Martinell M. , Carlsson P.O.
      Int. J. Endocrinol.2014:323407-323407(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN NIDDM
    15. 15.
      "Circulating betatrophin concentrations are decreased in human obesity and type 2 diabetes."
      Gomez-Ambrosi J. , Pascual E. , Catalan V. , Rodriguez A. , Ramirez B. , Silva C. , Gil M.J. , Salvador J. , Fruehbeck G.
      J. Clin. Endocrinol. Metab.99:E2004-E2004(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN NIDDM
    16. 16.
      "Circulating betatrophin levels are increased in patients with type 2 diabetes and associated with insulin resistance."
      Chen X. , Lu P. , He W. , Zhang J. , Liu L. , Yang Y. , Liu Z. , Xie J. , Shao S. , Du T. , Su X. , Zhou X. , Hu S. , Yuan G. , Zhang M. , Zhang H. , Liu L. , Wang D. , more...
      J. Clin. Endocrinol. Metab.0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN NIDDM
    17. 17.
      "Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity."
      Fu Z. , Berhane F. , Fite A. , Seyoum B. , Abou-Samra A.B. , Zhang R.
      Sci. Rep.4:5013-5013(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN NIDDM
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