PPP2R5B ELISA Kit for Human(Homo sapiens) | EIAab.comPPP2R5B ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PPP2R5B(Gene name) > Human

PPP2R5B (Gene name),

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (Protein name ), 2A5B_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PPP2R5B;

Protein name:

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform;

Alternative:

PP2A B subunit isoform B56-beta;PP2A B subunit isoform B'-beta;PP2A B subunit isoform R5-beta;PP2A B subunit isoform PR61-beta;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1. Interacts with AKT1.

Function:

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the 'Thr-308' and 'Ser-373' residues.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

497

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

497:

QQKAQERQEL | WQGLEELRLR | RLQGTQGAKE | APLQRLTPQV | AASGGQS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF01603

String:

Q15173

STRING:

9606.ENSP00000164133

SMR:

Q15173

MIM:

601644

KEGG:

hsa:5526

UniGene:

Hs.75199

Uniprot:

Q15173

FOR

ELISA Kit for Human Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

CLIA Kit for Human Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

Polyclonal Antibody for Human Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

Monoclonal Antibody for Human Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

Protein for Human Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification of a new family of protein phosphatase 2A regulatory subunits."
McCright B. , Virshup D.M.
J. Biol. Chem.270:26123-26128(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-1)
tissue: Fetal brain.
2.

"The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits."
Zolnierowicz S. , van Hoof C. , Andjelkovic N. , Cron P. , Stevens I. , Merlevede W. , Goris J. , Hemmings B.A.
Biochem. J.317:187-194(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA-2);PARTIAL PROTEIN SEQUENCE
tissue: Brain.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA-1)
tissue: Brain.
4.

"The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm."
McCright B. , Rivers A.M. , Audlin S. , Virshup D.M.
J. Biol. Chem.271:22081-22089(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;SUBCELLULAR LOCATION
5.

"Shugoshin collaborates with protein phosphatase 2A to protect cohesin."
Kitajima T.S. , Sakuno T. , Ishiguro K. , Iemura S. , Natsume T. , Kawashima S.A. , Watanabe Y.
Nature441:46-52(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SGOL1
6.

"Clk2 and B56-beta mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt."
Rodgers J.T. , Vogel R.O. , Puigserver P.
Mol. Cell41:471-479(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-32; SER-35; SER-44; SER-46; SER-47 AND SER-48;INTERACTION WITH AKT1

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