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Index > Protein center > ACE(Gene name) > Human
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  • ACE (Gene name),
  • Angiotensin-converting enzyme (Protein name ),  ACE_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    ACE(DCP;DCP1);
    Protein name:
    Angiotensin-converting enzyme(ACE);
    Alternative:
    Dipeptidyl carboxypeptidase I;Kininase II;
    CD:
    CD143;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1306
    Sequence:
    50:
    MGAASGRRGP | GLLLPLPLLL | LLPPQPALAL | DPGLQPGNFS | ADEAGAQLFA | 
    100:
    QSYNSSAEQV | LFQSVAASWA | HDTNITAENA | RRQEEAALLS | QEFAEAWGQK | 
    150:
    AKELYEPIWQ | NFTDPQLRRI | IGAVRTLGSA | NLPLAKRQQY | NALLSNMSRI | 
    200:
    YSTAKVCLPN | KTATCWSLDP | DLTNILASSR | SYAMLLFAWE | GWHNAAGIPL | 
    250:
    KPLYEDFTAL | SNEAYKQDGF | TDTGAYWRSW | YNSPTFEDDL | EHLYQQLEPL | 
    300:
    YLNLHAFVRR | ALHRRYGDRY | INLRGPIPAH | LLGDMWAQSW | ENIYDMVVPF | 
    350:
    PDKPNLDVTS | TMLQQGWNAT | HMFRVAEEFF | TSLELSPMPP | EFWEGSMLEK | 
    400:
    PADGREVVCH | ASAWDFYNRK | DFRIKQCTRV | TMDQLSTVHH | EMGHIQYYLQ | 
    450:
    YKDLPVSLRR | GANPGFHEAI | GDVLALSVST | PEHLHKIGLL | DRVTNDTESD | 
    500:
    INYLLKMALE | KIAFLPFGYL | VDQWRWGVFS | GRTPPSRYNF | DWWYLRTKYQ | 
    550:
    GICPPVTRNE | THFDAGAKFH | VPNVTPYIRY | FVSFVLQFQF | HEALCKEAGY | 
    600:
    EGPLHQCDIY | RSTKAGAKLR | KVLQAGSSRP | WQEVLKDMVG | LDALDAQPLL | 
    650:
    KYFQPVTQWL | QEQNQQNGEV | LGWPEYQWHP | PLPDNYPEGI | DLVTDEAEAS | 
    700:
    KFVEEYDRTS | QVVWNEYAEA | NWNYNTNITT | ETSKILLQKN | MQIANHTLKY | 
    750:
    GTQARKFDVN | QLQNTTIKRI | IKKVQDLERA | ALPAQELEEY | NKILLDMETT | 
    800:
    YSVATVCHPN | GSCLQLEPDL | TNVMATSRKY | EDLLWAWEGW | RDKAGRAILQ | 
    850:
    FYPKYVELIN | QAARLNGYVD | AGDSWRSMYE | TPSLEQDLER | LFQELQPLYL | 
    900:
    NLHAYVRRAL | HRHYGAQHIN | LEGPIPAHLL | GNMWAQTWSN | IYDLVVPFPS | 
    950:
    APSMDTTEAM | LKQGWTPRRM | FKEADDFFTS | LGLLPVPPEF | WNKSMLEKPT | 
    1000:
    DGREVVCHAS | AWDFYNGKDF | RIKQCTTVNL | EDLVVAHHEM | GHIQYFMQYK | 
    1050:
    DLPVALREGA | NPGFHEAIGD | VLALSVSTPK | HLHSLNLLSS | EGGSDEHDIN | 
    1100:
    FLMKMALDKI | AFIPFSYLVD | QWRWRVFDGS | ITKENYNQEW | WSLRLKYQGL | 
    1150:
    CPPVPRTQGD | FDPGAKFHIP | SSVPYIRYFV | SFIIQFQFHE | ALCQAAGHTG | 
    1200:
    PLHKCDIYQS | KEAGQRLATA | MKLGFSRPWP | EAMQLITGQP | NMSASAMLSY | 
    1250:
    FKPLLDWLRT | ENELHGEKLG | WPQYNWTPNS | ARSEGPLPDS | GRVSFLGLDL | 
    1300:
    DAQQARVGQW | LLLFLGIALL | VATLGLSQRL | FSIRHRSLHR | HSHGPQFGSE | 
    1306:
    VELRHS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    SMR:
    KEGG:
    UniGene:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human ACE
    Cat.:
    E0004h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human ACE
    Cat.:
    E0004m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human ACE
    Cat.:
    E0004r
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    96T
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    ELISA Kit for Human ACE
    Cat.:
    E0004b
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    Packing:
    96T
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    ELISA Kit for Human ACE
    MSDS:
    Please sign in first.
    ELISA Kit for Human ACE
    Cat.:
    E0004c
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ACE
    MSDS:
    Please sign in first.
    CLIA Kit for Human ACE
    Cat.:
    U0004h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ACE
    Cat.:
    U0004m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ACE
    Cat.:
    U0004r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ACE
    Cat.:
    U0004c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ACE
    Cat.:
    U0004b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human ACE
    Polyclonal Antibody for Human ACE
    Cat.:
    P0004Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ACE
    Polyclonal Antibody for Human ACE
    Cat.:
    P0004Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ACE
    Cat.:
    P0004Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ACE
    Monoclonal Antibody for Human ACE
    Monoclonal Antibody for Human ACE
    Monoclonal Antibody for Human ACE
    Monoclonal Antibody for Human ACE
    Monoclonal Antibody for Human ACE
    Monoclonal Antibody for Human ACE
    Protein for Human ACE
    Protein for Human ACE
    Protein for Human ACE
    Protein for Human ACE
    Protein for Human ACE
    Protein for Human ACE

    R&D Technical Data
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    s

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    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤4.0%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.9%



     

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    Recovery

    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery  Range (%)

    Serum

    101

    95-107

    Plasma

    99

    93-102

     

     

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    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    Saliva(n=3)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    93-104%

    91-101%

    95-102%

    96-109%

    Saliva(n=3)

    90-99%

    93- 99%

    89-97%

    92-106%

    heparin plasma(n=5)

    94-103%

     

    96-110%

    99-111%

    94-110%

     

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    References
    1. 1.
      "Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning."
      Soubrier F. , Alhenc-Gelas F. , Hubert C. , Allegrini J. , John M. , Tregear G. , Corbol P.
      Proc. Natl. Acad. Sci. U.S.A.85:9386-9390(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SOMATIC-1)
    2. 2.
      "The testicular transcript of the angiotensin I-converting enzyme encodes for the ancestral, non-duplicated form of the enzyme."
      Lattion A.L. , Soubrier F. , Allegrini J. , Hubert C. , Corvol P. , Alhenc-Gelas F.
      FEBS Lett.252:99-104(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TESTIS-SPECIFIC)
    3. 3.
      "Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme."
      Ehlers M.R.W. , Fox E.A. , Strydom D.J. , Riordan J.F.
      Proc. Natl. Acad. Sci. U.S.A.86:7741-7745(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TESTIS-SPECIFIC)
    4. 4.
      "Sequence variation in the human angiotensin converting enzyme."
      Rieder M.J. , Taylor S.L. , Clark A.G. , Nickerson D.A.
      Nat. Genet.22:59-62(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-261; TRP-561 AND SER-1286
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Testis.
    6. 6.
      NHLBI resequencing and genotyping service (RS&G)
      Submitted (2007-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1239 (ISOFORM SOMATIC-1)
      tissue: Brain.
    8. 9.
      "Purification of human lung angiotensin-converting enzyme by high-performance liquid chromatography: properties and N-terminal amino acid sequence."
      Takeuchi K. , Shimizu T. , Ohishi N. , Seyama Y. , Takaku F. , Yotsumoto H.
      J. Biochem.106:442-445(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-46
      tissue: Lung.
    9. 10.
      "Alternative splicing of the mRNA coding for the human endothelial angiotensin-converting enzyme: a new mechanism for solubilization."
      Sugimura K. , Tian X.-L. , Hoffmann S. , Ganten D. , Bader M.
      Biochem. Biophys. Res. Commun.247:466-472(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1114-1306 (ISOFORM SOMATIC-2);ALTERNATIVE SPLICING
      tissue: Umbilical vein endothelial cell.
    10. 11.
      "Angiotensin-converting enzyme: zinc- and inhibitor-binding stoichiometries of the somatic and testis isozymes."
      Ehlers M.R.W. , Riordan J.F.
      Biochemistry30:7118-7126(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ZINC-BINDING
    11. 12.
      "Assignment of free and disulfide-bonded cysteine residues in testis angiotensin-converting enzyme: functional implications."
      Sturrock E.D. , Yu X.C. , Wu Z. , Biemann K. , Riordan J.F.
      Biochemistry35:9560-9566(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    12. 13.
      "Identification of N-linked glycosylation sites in human testis angiotensin-converting enzyme and expression of an active deglycosylated form."
      Yu X.C. , Sturrock E.D. , Wu Z. , Biemann K. , Ehlers M.R.W. , Riordan J.F.
      J. Biol. Chem.272:3511-3519(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-38; ASN-54; ASN-111; ASN-146; ASN-509; ASN-695; ASN-714; ASN-760; ASN-942 AND ASN-1191;IDENTIFICATION BY MASS SPECTROMETRY
    13. 14.
      "Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites."
      Woodman Z.L. , Oppong S.Y. , Cook S. , Hooper N.M. , Schwager S.L.U. , Brandt W.F. , Ehlers M.R.W. , Sturrock E.D.
      Biochem. J.347:711-718(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE SITE;IDENTIFICATION BY MASS SPECTROMETRY
    14. 15.
      "A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9."
      Donoghue M. , Hsieh F. , Baronas E. , Godbout K. , Gosselin M. , Stagliano N. , Donovan M. , Woolf B. , Robison K. , Jeyaseelan R. , Breitbart R.E. , Acton S.
      Circ. Res.87:E1-E9(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    15. 16.
      "A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase."
      Tipnis S.R. , Hooper N.M. , Hyde R. , Karran E. , Christie G. , Turner A.J.
      J. Biol. Chem.275:33238-33243(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    16. 17.
      "Increased shedding of angiotensin-converting enzyme by a mutation identified in the stalk region."
      Eyries M. , Michaud A. , Deinum J. , Agrapart M. , Chomilier J. , Kramers C. , Soubrier F.
      J. Biol. Chem.276:5525-5532(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES;CHARACTERIZATION OF VARIANT LEU-1228
    17. 18.
      "CK2 phosphorylates the angiotensin-converting enzyme and regulates its retention in the endothelial cell plasma membrane."
      Kohlstedt K. , Shoghi F. , Mueller-Esterl W. , Busse R. , Fleming I.
      Circ. Res.91:749-756(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-1299;MUTAGENESIS OF SER-1299
    18. 19.
      "Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme."
      Harmer D. , Gilbert M. , Borman R. , Clark K.L.
      FEBS Lett.532:107-110(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    19. 20.
      "Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme."
      Gordon K. , Redelinghuys P. , Schwager S.L.U. , Ehlers M.R.W. , Papageorgiou A.C. , Natesh R. , Acharya K.R. , Sturrock E.D.
      Biochem. J.371:437-442(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES;CLEAVAGE SITE
    20. 21.
      "ACE2 gene expression is up-regulated in the human failing heart."
      Goulter A.B. , Goddard M.J. , Allen J.C. , Clark K.L.
      BMC Med.2:19-19(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    21. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
    22. 23.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-509; ASN-695 AND ASN-714
      tissue: Plasma.
    23. 24.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-111; ASN-445 AND ASN-714
      tissue: Liver.
    24. 25.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    25. 26.
      "Crystal structure of the human angiotensin-converting enzyme-lisinopril complex."
      Natesh R. , Schwager S.L.U. , Sturrock E.D. , Acharya K.R.
      Nature421:551-554(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 642-1230;X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 642-1230 IN COMPLEX WITH LISINOPRIL
    26. 27.
      "Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme."
      Natesh R. , Schwager S.L.U. , Evans H.R. , Sturrock E.D. , Acharya K.R.
      Biochemistry43:8718-8724(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 642-1230 IN COMPLEX WITH ENALAPRILAT;X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 642-1230 IN COMPLEX WITH CAPTOPRIL
    27. 28.
      "Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design."
      Corradi H.R. , Schwager S.L.U. , Nchinda A.T. , Sturrock E.D. , Acharya K.R.
      J. Mol. Biol.357:964-974(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 30-641 IN COMPLEX WITH LISINOPRIL; ZINC AND CHLORIDE IONS;GLYCOSYLATION AT ASN-54; ASN-74; ASN-146; ASN-318 AND ASN-509
    28. 29.
      "The DD genotype of the ACE gene polymorphism is associated with progression of diabetic nephropathy to end stage renal failure in IDDM."
      Vleming L.J. , van der Pijl J.W. , Lemkes H.H.P.J. , Westendorp R.G.J. , Maassen J.A. , Daha M.R. , van Es L.A. , van Kooten C.
      Clin. Nephrol.51:133-140(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN DIABETIC NEPHROPATHY SUSCEPTIBILITY
    29. 30.
      "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
      Halushka M.K. , Fan J.-B. , Bentley K. , Hsie L. , Shen N. , Weder A. , Cooper R. , Lipshutz R. , Chakravarti A.
      Nat. Genet.22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-1018; VAL-1051; GLN-1279; SER-1286 AND PRO-1296
    30. 31.
      "Point mutation in the stalk of angiotensin-converting enzyme causes a dramatic increase in serum angiotensin-converting enzyme but no cardiovascular disease."
      Kramers C. , Danilov S.M. , Deinum J. , Balyasnikova I.V. , Scharenborg N. , Looman M. , Boomsma F. , de Keijzer M.H. , van Duijn C. , Martin S. , Soubrier F. , Adema G.J.
      Circulation104:1236-1240(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-1228;ASSOCIATION WITH BENIGN SERUM INCREASE OF ANGIOTENSIN-CONVERTING ENZYME
    31. 32.
      "Hereditary elevation of angiotensin converting enzyme suggesting neurosarcoidosis."
      Linnebank M. , Kesper K. , Jeub M. , Urbach H. , Wuellner U. , Klockgether T. , Schmidt S.
      Neurology61:1819-1820(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-1228;ASSOCIATION WITH BENIGN SERUM INCREASE OF ANGIOTENSIN-CONVERTING ENZYME
    32. 33.
      "Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls."
      Casas J.P. , Hingorani A.D. , Bautista L.E. , Sharma P.
      Arch. Neurol.61:1652-1661(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ISCHSTR
    33. 34.
      "DD genotype of ACE gene is a risk factor for intracerebral hemorrhage."
      Slowik A. , Turaj W. , Dziedzic T. , Haefele A. , Pera J. , Malecki M.T. , Glodzik-Sobanska L. , Szermer P. , Figlewicz D.A. , Szczudlik A.
      Neurology63:359-361(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ICH
    34. 35.
      "Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis."
      Gribouval O. , Gonzales M. , Neuhaus T. , Aziza J. , Bieth E. , Laurent N. , Bouton J.M. , Feuillet F. , Makni S. , Ben Amar H. , Laube G. , Delezoide A.-L. , Bouvier R. , Dijoud F. , Ollagnon-Roman E. , Roume J. , Joubert M. , Antignac C. , more...
      Nat. Genet.37:964-968(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN RTD;VARIANT ARG-354
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