NUDT1 ELISA Kit for Human(Homo sapiens) | EIAab.comNUDT1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > NUDT1(Gene name) > Human

NUDT1 (Gene name),

7,8-dihydro-8-oxoguanine triphosphatase (Protein name ), 8ODP_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

NUDT1(MTH1);

Protein name:

7,8-dihydro-8-oxoguanine triphosphatase;

Alternative:

Nucleoside diphosphate-linked moiety X motif 1(Nudix motif 1);3.6.1.56;8-oxo-dGTPase);Nucleoside diphosphate-linked moiety X motif 1(Nudix motif 1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer.

Function:

Antimutagenic. Responsible for preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

197

Sequence:

50:

100:

150:

197:

QIPFKDMWPD | DSYWFPLLLQ | KKKFHGYFKF | QGQDTILDYT | LREVDTV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P36639

KEGG:

hsa:4521

MIM:

600312

STRING:

9606.ENSP00000339503

UniGene:

Hs.534331

Pfam:

PF00293

SMR:

P36639

Uniprot:

P36639

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ELISA Kit for Human 7,8-dihydro-8-oxoguanine triphosphatase

Cat.:

E3104h

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Manual:

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Packing:

96T

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ELISA Kit for Human 7,8-dihydro-8-oxoguanine triphosphatase

Cat.:

E3104m

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Manual:

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96T

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ELISA Kit for Human 7,8-dihydro-8-oxoguanine triphosphatase

Cat.:

E3104r

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Packing:

96T

CLIA Kit for Human 7,8-dihydro-8-oxoguanine triphosphatase

Cat.:

U3104h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human 7,8-dihydro-8-oxoguanine triphosphatase

Cat.:

U3104m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human 7,8-dihydro-8-oxoguanine triphosphatase

Cat.:

U3104r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human 7,8-dihydro-8-oxoguanine triphosphatase

Cat.:

P3104Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human 7,8-dihydro-8-oxoguanine triphosphatase

Cat.:

P3104Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human 7,8-dihydro-8-oxoguanine triphosphatase

Monoclonal Antibody for Human 7,8-dihydro-8-oxoguanine triphosphatase

Protein for Human 7,8-dihydro-8-oxoguanine triphosphatase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis."
Sakumi K. , Furuichi M. , Tsuzuki T. , Kakuma T. , Kawabata S. , Maki H. , Sekiguchi M.
J. Biol. Chem.268:23524-23530(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM P18);PARTIAL PROTEIN SEQUENCE;CATALYTIC ACTIVITY
2.

"Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion."
Furuichi M. , Yoshida M.C. , Oda H. , Tajiri T. , Nakabeppu Y. , Tsuzuki T. , Sekiguchi M.
Genomics24:485-490(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Regulation of expression of the human MTH1 gene encoding 8-oxo-dGTPase. Alternative splicing of transcription products."
Oda H. , Nakabeppu Y. , Furuichi M. , Sekiguchi M.
J. Biol. Chem.272:17843-17850(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM P18);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;VARIANT MET-124
4.

"Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism."
Oda H. , Taketomi A. , Maruyama R. , Itoh R. , Nishioka K. , Yakushiji H. , Suzuki T. , Sekiguchi M. , Nakabeppu Y.
Nucleic Acids Res.27:4335-4343(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS P18/P21/P22/P26);ALTERNATIVE INITIATION
5.

NIEHS SNPs program
Submitted (2005-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

"Human chromosome 7: DNA sequence and biology."
Scherer S.W. , Cheung J. , MacDonald J.R. , Osborne L.R. , Nakabayashi K. , Herbrick J.-A. , Carson A.R. , Parker-Katiraee L. , Skaug J. , Khaja R. , Zhang J. , Hudek A.K. , Li M. , Haddad M. , Duggan G.E. , Fernandez B.A. , Kanematsu E. , Gentles S. , more...
Science300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM P18)
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The DNA sequence of human chromosome 7."
Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS P18 AND P22);VARIANT MET-124
tissue: Bone.
tissue: Lymph.
tissue: Mammary gland.
tissue: Muscle.
11.

"Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria."
Kang D. , Nishida J. , Iyama A. , Nakabeppu Y. , Furuichi M. , Fujiwara T. , Sekiguchi M. , Takeshige K.
J. Biol. Chem.270:14659-14665(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
12.

"The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein."
Fujikawa K. , Kamiya H. , Yakushiji H. , Fujii Y. , Nakabeppu Y. , Kasai H.
J. Biol. Chem.274:18201-18205(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
13.

"Functional significance of the conserved residues for the 23-residue module among MTH1 and MutT family proteins."
Fujii Y. , Shimokawa H. , Sekiguchi M. , Nakabeppu Y.
J. Biol. Chem.274:38251-38259(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF GLY-77; GLY-78; VAL-80; GLN-81; GLY-83; ILE-86; ASP-88; GLY-89; ALA-90; LEU-94; GLN-95; GLU-96; GLU-97 AND SER-98;FUNCTION;CATALYTIC ACTIVITY
14.

"Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP."
Fujikawa K. , Kamiya H. , Yakushiji H. , Nakabeppu Y. , Kasai H.
Nucleic Acids Res.29:449-454(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES
15.

"A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1."
Sakai Y. , Furuichi M. , Takahashi M. , Mishima M. , Iwai S. , Shirakawa M. , Nakabeppu Y.
J. Biol. Chem.277:8579-8587(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;MUTAGENESIS OF PHE-68; TRP-158; ASP-160; LEU-191; ARG-192; GLU-193; VAL-194; ASP-195; THR-196; VAL-197; 192-ARG--VAL-197; 193-GLU--VAL-197; 194-VAL-VAL-197 AND 195-ASP--VAL-197
16.

"An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress."
Yoshimura D. , Sakumi K. , Ohno M. , Sakai Y. , Furuichi M. , Iwai S. , Nakabeppu Y.
J. Biol. Chem.278:37965-37973(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
17.

"The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal."
Sakai Y. , Oda H. , Yoshimura D. , Furuichi M. , Kang D. , Iwai S. , Hara T. , Nakabeppu Y.
J. Mol. Med.84:660-670(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;SUBCELLULAR LOCATION
18.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2."
Takagi Y. , Setoyama D. , Ito R. , Kamiya H. , Yamagata Y. , Sekiguchi M.
J. Biol. Chem.287:21541-21549(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY
20.

"Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates."
Mishima M. , Sakai Y. , Itoh N. , Kamiya H. , Furuichi M. , Takahashi M. , Yamagata Y. , Iwai S. , Nakabeppu Y. , Shirakawa M.
J. Biol. Chem.279:33806-33815(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 42-197;SUBUNIT;COFACTOR;SUBSTRATE BINDING SITE
21.

"Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP."
Nakamura T. , Kitaguchi Y. , Miyazawa M. , Kamiya H. , Toma S. , Ikemizu S. , Shirakawa M. , Nakabeppu Y. , Yamagata Y.
Acta Crystallogr. F62:1283-1285(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CRYSTALLIZATION;PRELIMINARY X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS)
22.

"Crystal structure of human MTH1 and the 8-oxo-dGMP product complex."
Svensson L.M. , Jemth A.S. , Desroses M. , Loseva O. , Helleday T. , Hogbom M. , Stenmark P.
FEBS Lett.585:2617-2621(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 42-197 IN COMPLEX WITH 8-OXO-DGMP;BIOPHYSICOCHEMICAL PROPERTIES
23.

"Crystal Structure of Human 8-oxo-dGTPase (MTH1)."
Structural genomics consortium (SGC) , Tresaugues L. , Siponen M.I. , Arrowsmith C.H. , Berglund H. , Bountra C. , Collins R. , Edwards A.M. , Ekblad T. , Flodin S. , Flores A. , Graslund S. , Hammarstrom M. , Johansson I. , Karlberg T. , Kol S. , Kotenyova T. , Kouznetsova E. , more...
Submitted (2011-01) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 42-197
24.

"Association study of human MTH1 gene polymorphisms with type 1 diabetes mellitus."
Miyako K. , Kohno H. , Ihara K. , Kuromaru R. , Matsuura N. , Hara T.
Endocr. J.51:493-498(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-124
25.

"Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk."
Kohno T. , Sakiyama T. , Kunitoh H. , Goto K. , Nishiwaki Y. , Saito D. , Hirose H. , Eguchi T. , Yanagitani N. , Saito R. , Sasaki-Matsumura R. , Mimaki S. , Toyama K. , Yamamoto S. , Kuchiba A. , Sobue T. , Ohta T. , Ohki M. , more...
Carcinogenesis27:2448-2454(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-124

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