SERPINA1 ELISA Kit for Human(Homo sapiens) | EIAab.comSERPINA1 ELISA Kit for Human(Homo sapiens)

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SERPINA1 (Gene name),

Alpha-1-antitrypsin (Protein name ), A1AT_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SERPINA1(PRO0684;PRO2209;AAT;PI);

Protein name:

Alpha-1-antitrypsin;

Alternative:

Alpha-1-antiproteinase;Alpha-1 protease inhibitor;Serpin A1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Short peptide from AAT (SPAAT) is a reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).

Subcellular Location:

Short peptide from AAT Secreted extracellular space extracellular matrix

Protein Attributes:

Sequence length:

418

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

418:

QNTKSPLFMG | KVVNPTQK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P01009

MIM:

107400

UniGene:

Hs.525557

KEGG:

hsa:5265

String:

P01009

Pfam:

PF00079

Uniprot:

P01009

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ELISA Kit for Human Alpha-1-antitrypsin

Cat.:

E1697r

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96T

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ELISA Kit for Human Alpha-1-antitrypsin

Cat.:

E1697b

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96T

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ELISA Kit for Human Alpha-1-antitrypsin

Cat.:

E1697p

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96T

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ELISA Kit for Human Alpha-1-antitrypsin

Cat.:

E1697h

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96T

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CLIA Kit for Human Alpha-1-antitrypsin

Cat.:

U1697h

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96T

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CLIA Kit for Human Alpha-1-antitrypsin

Cat.:

U1697p

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MSDS:

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Packing:

96T

CLIA Kit for Human Alpha-1-antitrypsin

Cat.:

U1697b

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MSDS:

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Packing:

96T

CLIA Kit for Human Alpha-1-antitrypsin

Cat.:

U1697r

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96T

Polyclonal Antibody for Human Alpha-1-antitrypsin

Cat.:

P1697Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Alpha-1-antitrypsin

Cat.:

P1697Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Alpha-1-antitrypsin

Protein for Human Alpha-1-antitrypsin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Cloning and expression in Escherichia coli of full-length complementary DNA coding for human alpha 1-antitrypsin."
Bollen A. , Herzog A. , Cravador A. , Herion P. , Chuchana P. , van der Straten A. , Loriau R. , Jacobs P. , van Elsen A.
DNA2:255-264(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Complete sequence of the cDNA for human alpha 1-antitrypsin and the gene for the S variant."
Long G.L. , Chandra T. , Woo S.L.C. , Davie E.W. , Kurachi K.
Biochemistry23:4828-4837(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Synthesis in yeast of a functional oxidation-resistant mutant of human alpha-antitrypsin."
Rosenberg S. , Barr P.J. , Najarian R.C. , Hallewell R.A.
Nature312:77-80(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);MUTAGENESIS OF MET-382
4.

"Cell-specific expression of a transfected human alpha 1-antitrypsin gene."
Ciliberto G. , Dente L. , Cortese R.
Cell41:531-540(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
5.

"Identification of a second mutation in the protein-coding sequence of the Z type alpha 1-antitrypsin gene."
Nukiwa T. , Satoh K. , Brantly M.L. , Ogushi F. , Fells G.A. , Courtney M. , Crystal R.G.
J. Biol. Chem.261:15989-15994(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];CHARACTERIZATION OF VARIANT Z
6.

Nukiwa T. , Satoh K. , Brantly M.L. , Ogushi F. , Fells G.A. , Courtney M. , Crystal R.G.
J. Biol. Chem.262:10412-10412(1987)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
7.

"An alpha-1 antitrypsin genetic variant from India."
Shasany A.K. , Shukla A.K. , Darokar M.P. , Saraiya M. , Chaturvedi N. , Tewari L. , Khanuja S.P.
Indian J. Biochem. Biophys.44:176-178(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ALA-237 AND ASP-400
tissue: Liver.
8.

"Characterization of a new variant of alpha1 antitrypsin M Lille (p.Gly148Trp)."
Balduyck M. , Porchet N. , Aubert J.-P. , Zerimech F. , Douchain F. , Verchain S.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS TRP-172; ALA-237 AND LYS-366
tissue: Lymphocyte.
9.

"Functional prediction of the coding sequences of 32 new genes deduced by analysis of cDNA clones from human fetal liver."
Zhang C. , Yu Y. , Zhang S. , Ouyang S. , Luo L. , Wei H. , Zhou G. , Zhou W. , Bi J. , Zhang Y. , Liu M. , He F.
Submitted (1998-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Fetal liver.
10.

"Full-length cDNA libraries and normalization."
Li W.B. , Gruber C. , Jessee J. , Polayes D.
Submitted (2003-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
tissue: Fetal liver.
tissue: Placenta.
11.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Synovium.
12.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-237
13.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Colon.
tissue: Ovary.
14.

"Sequence homology and structural comparison between the chromosomal human alpha 1-antitrypsin and chicken ovalbumin genes."
Leicht M. , Long G.L. , Chandra T. , Kurachi K. , Kidd V.J. , Mace M. Jr. , Davie E.W. , Woo S.L.C.
Nature297:655-659(1982) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-67; 196-255 AND 387-418
15.

"The covalent structure of human alpha1-protease inhibitor."
Chan S.K.
Fed. Proc.41:1016-1016(1982)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRELIMINARY PROTEIN SEQUENCE OF 25-418 (ISOFORM 1)
16.

"Structure and variation of human alpha 1-antitrypsin."
Carrell R.W. , Jeppsson J.-O. , Laurell C.-B. , Brennan S.O. , Owen M.C. , Vaughan L. , Boswell D.R.
Nature298:329-334(1982) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-418 (ISOFORM 1)
17.

"Appearance of an aberrant form of alpha-antitrypsin in the circulation of chronic cigarette smokers and its effect on the insulin induced NO synthesis in blood platelets."
Sinha A.K. , Girish G.V.
Submitted (2007-08) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-418 (ISOFORM 1);VARIANTS ABERRANT FORM 190-GLY--ARG-198 AND VAL-288;FUNCTION
tissue: Blood.
18.

"Characterization of a 54 kDa, alpha 1-antitrypsin-like protein isolated from ascitic fluid of an endometrial cancer patient."
Tanaka N. , Sekiya S. , Takamizawa H. , Kato N. , Moriyama Y. , Fujimura S.
Jpn. J. Cancer Res.82:693-700(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-39;FUNCTION
tissue: Ascites.
19.

"Comprehensive glyco-proteomic analysis of human alpha1-antitrypsin and its charge isoforms."
Kolarich D. , Weber A. , Turecek P.L. , Schwarz H.P. , Altmann F.
Proteomics6:3369-3380(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-48 AND 248-257 (ISOFORMS 1/2/3);GLYCOSYLATION AT ASN-70; ASN-107 AND ASN-271;STRUCTURE OF CARBOHYDRATES;CYSTEINE-BINDING;IDENTIFICATION BY MASS SPECTROMETRY
20.

"Sequencing of a urinary stone protein, identical to alpha-one antitrypsin, which lacks 22 amino acids."
Umekawa T. , Kohri K. , Amasaki N. , Yamate T. , Yoshida K. , Yamamoto K. , Suzuki Y. , Sinohara H. , Kurita T.
Biochem. Biophys. Res. Commun.193:1049-1053(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 47-66
tissue: Urine.
21.

Lubec G. , Afjehi-Sadat L.
Submitted (2007-03) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 50-63 AND 161-178 (ISOFORMS 1/2/3);IDENTIFICATION BY MASS SPECTROMETRY
tissue: Brain.
tissue: Cajal-Retzius cell.
22.

"Alpha 1-antitrypsin and serum albumin mRNA accumulation in normal, acute phase and ZZ human liver."
Riley J.H. , Bathurst I.C. , Edbrooke M.R. , Carrell R.W. , Craig R.K.
FEBS Lett.189:361-366(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 292-418 (ISOFORM 1)
23.

"Cloning and sequence of cDNA coding for alpha 1-antitrypsin."
Kurachi K. , Chandra T. , Friezner Degen S.J. , White T.T. , Marchioro T.L. , Woo S.L.C. , Davie E.W.
Proc. Natl. Acad. Sci. U.S.A.78:6826-6830(1981) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 350-418 (ISOFORM 1)
24.

"Isolation and serine protease inhibitory activity of the 44-residue, C-terminal fragment of alpha 1-antitrypsin from human placenta."
Niemann M.A. , Narkates A.J. , Miller E.J.
Matrix12:233-241(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 375-414;IDENTIFICATION OF SPAAT;FUNCTION;SUBCELLULAR LOCATION
tissue: Placenta.
25.

"Construction and partial characterization of a human liver cDNA library."
Coutelle C. , Speer A. , Rogers J. , Kalsheker N. , Humphries S. , Williamson R.
Biomed. Biochim. Acta44:421-431(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 387-418 (ISOFORM 1)
26.

"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-70 AND ASN-271
27.

"A proteomic analysis of human bile."
Kristiansen T.Z. , Bunkenborg J. , Gronborg M. , Molina H. , Thuluvath P.J. , Argani P. , Goggins M.G. , Maitra A. , Pandey A.
Mol. Cell. Proteomics3:715-728(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-70 AND ASN-271
tissue: Bile.
28.

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-70 AND ASN-271
tissue: Plasma.
29.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-70; ASN-107 AND ASN-271
tissue: Plasma.
30.

"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-70
tissue: Platelet.
31.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-70; ASN-107 AND ASN-271
tissue: Liver.
32.

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-107 AND ASN-271
33.

"Enrichment of glycopeptides for glycan structure and attachment site identification."
Nilsson J. , Rueetschi U. , Halim A. , Hesse C. , Carlsohn E. , Brinkmalm G. , Larson G.
Nat. Methods6:809-811(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-70; ASN-107 AND ASN-271;STRUCTURE OF CARBOHYDRATES
tissue: Cerebrospinal fluid.
34.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
35.

"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Halim A. , Nilsson J. , Ruetschi U. , Hesse C. , Larson G.
Mol. Cell. Proteomics0:0-0(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-70 AND ASN-271;STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY
36.

"Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function."
Loebermann H. , Tokuoka R. , Deisenhofer J. , Huber R.
J. Mol. Biol.177:531-556(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS)
37.

"The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism."
Engh R. , Loebermann H. , Schneider M. , Wiegand G. , Huber R. , Laurell C.-B.
Protein Eng.2:407-415(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS)
38.

"Crystal structure of an uncleaved alpha 1-antitrypsin reveals the conformation of its inhibitory reactive loop."
Song H.K. , Lee K.N. , Kwon K.-S. , Yu M.-H. , Suh S.W.
FEBS Lett.377:150-154(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.46 ANGSTROMS) OF 25-418
39.

"Inhibitory conformation of the reactive loop of alpha 1-antitrypsin."
Elliott P.R. , Lomas D.A. , Carrell R.W. , Abrahams J.P.
Nat. Struct. Biol.3:676-681(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 26-418
40.

"The native strains in the hydrophobic core and flexible reactive loop of a serine protease inhibitor: crystal structure of an uncleaved alpha1-antitrypsin at 2.7 A."
Ryu S.-E. , Choi H.-J. , Kwon K.-S. , Lee K.N. , Yu M.-H.
Structure4:1181-1192(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 45-418
41.

"Wild-type alpha 1-antitrypsin is in the canonical inhibitory conformation."
Elliott P.R. , Abrahams J.P. , Lomas D.A.
J. Mol. Biol.275:419-425(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 26-418
42.

"Structure of a serpin-protease complex shows inhibition by deformation."
Huntington J.A. , Read R.J. , Carrell R.W.
Nature407:923-926(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 48-418 IN COMPLEX WITH BOVINE TRYPSIN
43.

"Cleaved antitrypsin polymers at atomic resolution."
Dunstone M.A. , Dai W. , Whisstock J.C. , Rossjohn J. , Pike R.N. , Feil S.C. , Le Bonniec B.F. , Parker M.W. , Bottomley S.P.
Protein Sci.9:417-420(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 44-418
44.

"Topography of a 2.0 A structure of alpha1-antitrypsin reveals targets for rational drug design to prevent conformational disease."
Elliott P.R. , Pei X.Y. , Dafforn T.R. , Lomas D.A.
Protein Sci.9:1274-1281(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS)
45.

"A 2.1 A resolution structure of an uncleaved alpha(1)-antitrypsin shows variability of the reactive center and other loops."
Kim S.-J. , Woo J.-R. , Seo E.J. , Yu M.-H. , Ryu S.-E.
J. Mol. Biol.306:109-119(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 25-418
46.

"Interactions causing the kinetic trap in serpin protein folding."
Im H. , Woo M.-S. , Hwang K.Y. , Yu M.-H.
J. Biol. Chem.277:46347-46354(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 25-418
47.

"Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases."
Dementiev A. , Simonovic M. , Volz K. , Gettins P.G.
J. Biol. Chem.278:37881-37887(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 26-418 OF VARIANT PITTSBURGH ARG-382
48.

"Alpha 1-antitrypsin: structure, function and molecular biology of the gene."
Kalsheker N.
Biosci. Rep.9:129-138(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
49.

"The molecular genetics of alpha 1 antitrypsin deficiency."
Wu Y. , Foreman R.C.
Bioessays13:163-169(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
50.

"Characterization of the gene and protein of the common alpha 1-antitrypsin normal M2 allele."
Nukiwa T. , Brantly M.L. , Ogushi F. , Fells G.A. , Crystal R.G.
Am. J. Hum. Genet.43:322-330(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT M2
51.

"Characterisation of the alpha-1-antitrypsin M3 gene, a normal variant."
Graham A. , Hayes K. , Weidinger S. , Newton C.R. , Markham A.F. , Kalsheker N.A.
Hum. Genet.85:381-382(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT M3 ASP-400
52.

"Characterization of the molecular basis of the alpha 1-antitrypsin F allele."
Okayama H. , Brantly M. , Holmes M. , Crystal R.G.
Am. J. Hum. Genet.48:1154-1158(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT F CYS-247
53.

"A Pro-->Leu substitution in codon 369 of the alpha-1-antitrypsin deficiency variant PI M-Heerlen."
Hofker M.H. , Nukiwa T. , van Paassen H.M.B. , Nelen M. , Kramps J.A. , Klasen E.C. , Frants R.R. , Crystal R.G.
Hum. Genet.81:264-268(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT M-HEERLEN LEU-393
54.

"In-frame single codon deletion in the M-Malton deficiency allele of alpha 1-antitrypsin."
Fraizer G.C. , Harrold T.R. , Hofker M.H. , Cox D.W.
Am. J. Hum. Genet.44:894-902(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT M-MALTON PHE-75 DEL
55.

"Molecular basis of alpha 1-antitrypsin deficiency and emphysema associated with the alpha 1-antitrypsin M-Mineral springs allele."
Curiel D.T. , Vogelmeier C. , Hubbard R.C. , Stier L.E. , Crystal R.G.
Mol. Cell. Biol.10:47-56(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT M-MINERAL SPRINGS GLU-91
56.

"Molecular analysis of the gene of the alpha 1-antitrypsin deficiency variant, M-Nichinan."
Matsunaga E. , Shiokawa S. , Nakamura H. , Maruyama T. , Tsuda K. , Fukumaki Y.
Am. J. Hum. Genet.46:602-612(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT M-NICHINAN PHE-75 DEL
57.

"Characterization of the gene and protein of the alpha 1-antitrypsin 'deficiency' allele M-Procida."
Takahashi H. , Nukiwa T. , Satoh K. , Ogushi F. , Brantly M. , Fells G. , Stier L. , Courtney M. , Crystal R.G.
J. Biol. Chem.263:15528-15534(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT M-PROCIDA PRO-65
58.

"Genetic diversity from a limited repertoire of mutations on different common allelic backgrounds: alpha 1-antitrypsin deficiency variant P-Duarte."
Hildesheim J. , Kinsley G. , Bissell M. , Pierce J. , Brantly M.
Hum. Mutat.2:221-228(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT P-DUARTE VAL-280
59.

"Mutation of antitrypsin to antithrombin. Alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder."
Owen M.C. , Brennan S.O. , Lewis J.H. , Carrell R.W.
N. Engl. J. Med.309:694-698(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT OF VARIANT PITTSBURGH ARG-382 IN BLEEDING DIATHESIS
60.

"Siiyama (serine 53 (TCC) to phenylalanine 53 (TTC)). A new alpha 1-antitrypsin-deficient variant with mutation on a predicted conserved residue of the serpin backbone."
Seyama K. , Nukiwa T. , Takabe K. , Takahashi H. , Miyake K. , Kira S.
J. Biol. Chem.266:12627-12632(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN A1ATD;VARIANT S-IIYAMA PHE-77
61.

"Characterization of the normal alpha 1-antitrypsin allele V-Munich: a variant associated with a unique protein isoelectric focusing pattern."
Holmes M.D. , Brantly M.L. , Curiel D.T. , Weidinger S. , Crystal R.G.
Am. J. Hum. Genet.46:810-816(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT V-MUNICH ALA-26
62.

"Alpha 1-antitrypsin W-Bethesda: molecular basis of an unusual alpha 1-antitrypsin deficiency variant."
Holmes M.D. , Brantly M.L. , Fells G.A. , Crystal R.G.
Biochem. Biophys. Res. Commun.170:1013-1020(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN A1ATD;VARIANT W-BETHESDA THR-360
63.

"Sequence data of the rare deficient alpha 1-antitrypsin variant PI Zaugsburg."
Faber J.-P. , Weidinger S. , Olek K.
Am. J. Hum. Genet.46:1158-1162(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT Z-AUGSBURG LYS-366
64.

"Molecular characterisation of two alpha-1-antitrypsin deficiency variants: proteinase inhibitor (Pi) Null(Newport) (Gly115-->Ser) and (Pi) Z Wrexham (Ser-19-->Leu)."
Graham A. , Kalsheker N.A. , Bamforth F.J. , Newton C.R. , Markham A.F.
Hum. Genet.85:537-540(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN A1ATD;VARIANTS Z-WREXHAM LEU-4 AND Q0-NEWPORT SER-139
65.

"Molecular characterisation of three alpha-1-antitrypsin deficiency variants: proteinase inhibitor (Pi) nullcardiff (Asp256-->Val); PiM-Malton (Phe51-->deletion) and PiI (Arg39-->Cys)."
Graham A. , Kalsheker N.A. , Newton C.R. , Bamforth F.J. , Powell S.J. , Markham A.F.
Hum. Genet.84:55-58(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS P-CARDIFF VAL-280; I CYS-63 AND M-MALTON PHE-75 DEL
66.

"A null deficiency allele of alpha 1-antitrypsin, QO-Ludwigshafen, with altered tertiary structure."
Fraizer G.C. , Siewertsen M.A. , Hofker M.H. , Brubacher M.G. , Cox D.W.
J. Clin. Invest.86:1878-1884(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT QO-LUDWIGSHAFEN ASN-116
67.

"Identification and DNA sequence analysis of 15 new alpha 1-antitrypsin variants, including two PI*Q0 alleles and one deficient PI*M allele."
Faber J.-P. , Poller W. , Weidinger S. , Kirchgesser M. , Schwaab R. , Bidlingmaier F. , Olek K.
Am. J. Hum. Genet.55:1113-1121(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS
68.

"A new alpha 1-antitrypsin mutation, Thr-Met 85, (PI ZBristol) associated with novel electrophoretic properties."
Lovegrove J.U. , Jeremiah S. , Gillett G.T. , Temple I.K. , Povey S. , Whitehouse D.B.
Ann. Hum. Genet.61:385-391(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT Z-BRISTOL MET-109
69.

"Identification and molecular characterization of the new alpha-1-antitrypsin deficient allele PI YBarcelona (Asp256Val and Pro391His)."
Jardi R. , Rodriguez F. , Miravitlles M. , Vidal R. , Cotrina M. , Quer J. , Pascual C. , Weidinger S.
Hum. Mutat.12:213-213(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS Y-BARCELONA VAL-280 AND HIS-415
70.

"A novel alpha-1-antitrypsin P362H variant found in a population sample from Sao Tome e Principe (Gulf of Guinea, West Africa)."
Seixas S. , Trovoada M.J. , Santos M.T. , Rocha J.
Hum. Mutat.13:414-414(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SAO TOME HIS-386
71.

"A novel alpha-1-antitrypsin r281del variant found in a population sample from the Basque country."
Seixas S. , Garcia O. , Amorim A. , Rocha J.
Hum. Mutat.15:121-122(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BASQUE ARG-305 DEL
72.

"SERPINA2 is a novel gene with a divergent function from SERPINA1."
Marques P.I. , Ferreira Z. , Martins M. , Figueiredo J. , Silva D.I. , Castro P. , Morales-Hojas R. , Simoes-Correia J. , Seixas S.
PLoS ONE8:E66889-E66889(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS Z ALA-237 AND LYS-366;VARIANT S VAL-288;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;GLYCOSYLATION;INTERACTION WITH CANX AND PDIA3

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