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Index > Protein center > A2ML1(Gene name) > Human
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  • A2ML1 (Gene name),
  • Alpha-2-macroglobulin-like protein 1 (Protein name ),  A2ML1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    A2ML1(CPAMD9);
    Protein name:
    Alpha-2-macroglobulin-like protein 1;
    Alternative:
    C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    1454
    Sequence:
    50:
    MWAQLLLGML | ALSPAIAEEL | PNYLVTLPAR | LNFPSVQKVC | LDLSPGYSDV | 
    100:
    KFTVTLETKD | KTQKLLEYSG | LKKRHLHCIS | FLVPPPAGGT | EEVATIRVSG | 
    150:
    VGNNISFEEK | KKVLIQRQGN | GTFVQTDKPL | YTPGQQVYFR | IVTMDSNFVP | 
    200:
    VNDKYSMVEL | QDPNSNRIAQ | WLEVVPEQGI | VDLSFQLAPE | AMLGTYTVAV | 
    250:
    AEGKTFGTFS | VEEYVLPKFK | VEVVEPKELS | TVQESFLVKI | CCRYTYGKPM | 
    300:
    LGAVQVSVCQ | KANTYWYREV | EREQLPDKCR | NLSGQTDKTG | CFSAPVDMAT | 
    350:
    FDLIGYAYSH | QINIVATVVE | EGTGVEANAT | QNIYISPQMG | SMTFEDTSNF | 
    400:
    YHPNFPFSGK | IRVRGHDDSF | LKNHLVFLVI | YGTNGTFNQT | LVTDNNGLAP | 
    450:
    FTLETSGWNG | TDVSLEGKFQ | MEDLVYNPEQ | VPRYYQNAYL | HLRPFYSTTR | 
    500:
    SFLGIHRLNG | PLKCGQPQEV | LVDYYIDPAD | ASPDQEISFS | YYLIGKGSLV | 
    550:
    MEGQKHLNSK | KKGLKASFSL | SLTFTSRLAP | DPSLVIYAIF | PSGGVVADKI | 
    600:
    QFSVEMCFDN | QVSLGFSPSQ | QLPGAEVELQ | LQAAPGSLCA | LRAVDESVLL | 
    650:
    LRPDRELSNR | SVYGMFPFWY | GHYPYQVAEY | DQCPVSGPWD | FPQPLIDPMP | 
    700:
    QGHSSQRSII | WRPSFSEGTD | LFSFFRDVGL | KILSNAKIKK | PVDCSHRSPE | 
    750:
    YSTAMGAGGG | HPEAFESSTP | LHQAEDSQVR | QYFPETWLWD | LFPIGNSGKE | 
    800:
    AVHVTVPDAI | TEWKAMSFCT | SQSRGFGLSP | TVGLTAFKPF | FVDLTLPYSV | 
    850:
    VRGESFRLTA | TIFNYLKDCI | RVQTDLAKSH | EYQLESWADS | QTSSCLCADD | 
    900:
    AKTHHWNITA | VKLGHINFTI | STKILDSNEP | CGGQKGFVPQ | KGRSDTLIKP | 
    950:
    VLVKPEGVLV | EKTHSSLLCP | KGKVASESVS | LELPVDIVPD | STKAYVTVLG | 
    1000:
    DIMGTALQNL | DGLVQMPSGC | GEQNMVLFAP | IIYVLQYLEK | AGLLTEEIRS | 
    1050:
    RAVGFLEIGY | QKELMYKHSN | GSYSAFGERD | GNGNTWLTAF | VTKCFGQAQK | 
    1100:
    FIFIDPKNIQ | DALKWMAGNQ | LPSGCYANVG | NLLHTAMKGG | VDDEVSLTAY | 
    1150:
    VTAALLEMGK | DVDDPMVSQG | LRCLKNSATS | TTNLYTQALL | AYIFSLAGEM | 
    1200:
    DIRNILLKQL | DQQAIISGES | IYWSQKPTPS | SNASPWSEPA | AVDVELTAYA | 
    1250:
    LLAQLTKPSL | TQKEIAKATS | IVAWLAKQHN | AYGGFSSTQD | TVVALQALAK | 
    1300:
    YATTAYMPSE | EINLVVKSTE | NFQRTFNIQS | VNRLVFQQDT | LPNVPGMYTL | 
    1350:
    EASGQGCVYV | QTVLRYNILP | PTNMKTFSLS | VEIGKARCEQ | PTSPRSLTLT | 
    1400:
    IHTSYVGSRS | SSNMAIVEVK | MLSGFSPMEG | TNQLLLQQPL | VKKVEFGTDT | 
    1450:
    LNIYLDELIK | NTQTYTFTIS | QSVLVTNLKP | ATIKVYDYYL | PDEQATIQYS | 
    1454:
    DPCE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    MIM:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Alpha-2-macroglobulin-like protein 1
    CLIA Kit for Human Alpha-2-macroglobulin-like protein 1
    Polyclonal Antibody for Human Alpha-2-macroglobulin-like protein 1
    Monoclonal Antibody for Human Alpha-2-macroglobulin-like protein 1
    Protein for Human Alpha-2-macroglobulin-like protein 1

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS GLU-850; TRP-1122; ARG-1229; VAL-1257 AND MET-1312
      tissue: Brain.
      tissue: Testis.
      tissue: Tongue.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS GLU-850; TRP-1122; ARG-1229 AND VAL-1257
      tissue: Cervix.
    3. 3.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS GLU-850; TRP-1122; ARG-1229 AND VAL-1257
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1290-1454
      tissue: Brain.
    6. 6.
      "A novel protease inhibitor of the alpha2-macroglobulin family expressed in the human epidermis."
      Galliano M.-F. , Toulza E. , Gallinaro H. , Jonca N. , Ishida-Yamamoto A. , Serre G. , Guerrin M.
      J. Biol. Chem.281:5780-5789(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
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