Protein name:
    Arylacetamide deacetylase ;
    
    Alternative:
    
    
    
 
    Organism:
        
        
        
        
        
        
    
        Human  (Homo sapiens).  
    
 
General Annotation
    Function:
    Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores.
    
 
    
        
        Subcellular Location:
        
    
     
     
      Endoplasmic reticulum membrane  
      Single-pass type II membrane protein 
      
     
      Microsome membrane  
      Single-pass type II membrane protein 
     
  
    
 
    
    Protein Attributes:
    
    50:
    MGRKSLYLLI |  VGILIAYYIY |  TPLPDNVEEP |  WRMMWINAHL |  KTIQNLATFV |  
    
 
    100:
    ELLGLHHFMD |  SFKVVGSFDE |  VPPTSDENVT |  VTETKFNNIL |  VRVYVPKRKS |  
    
 
    150:
    EALRRGLFYI |  HGGGWCVGSA |  ALSGYDLLSR |  WTADRLDAVV |  VSTNYRLAPK |  
    
 
    200:
    YHFPIQFEDV |  YNALRWFLRK |  KVLAKYGVNP |  ERIGISGDSA |  GGNLAAAVTQ |  
    
 
    250:
    QLLDDPDVKI |  KLKIQSLIYP |  ALQPLDVDLP |  SYQENSNFLF |  LSKSLMVRFW |  
    
 
    300:
    SEYFTTDRSL |  EKAMLSRQHV |  PVESSHLFKF |  VNWSSLLPER |  FIKGHVYNNP |  
    
 
    350:
    NYGSSELAKK |  YPGFLDVRAA |  PLLADDNKLR |  GLPLTYVITC |  QYDLLRDDGL |  
    
 
    399:
    MYVTRLRNTG |  VQVTHNHVED |  GFHGAFSFLG |  LKISHRLINQ |  YIEWLKENL
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Rabbit
         
        
        Human
         
        
        Mouse
         
        
        Bovine
         
        
        Rat
         
        
     
    
        ELISA Kit for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        ELISA Kit for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        ELISA Kit for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        ELISA Kit for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        ELISA Kit for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        Protein for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        Protein for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        Protein for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        Protein for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
    
        Protein for Human Arylacetamide deacetylase
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
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    Precision
    
    
    
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    Linearity
    
    
    
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    References
    
    
        
            
        
            
                1.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;VARIANT ILE-281 
                    
                    
                    tissue :
                    
Liver .  
             
         
            
        
            
                2.
                
                    
                        
                            "Complete sequencing and characterization of 21,243 full-length human cDNAs." 
                        
                        
                            Ota T. 
                        ,
                            
Suzuki Y. 
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                              more...   
                             
                        
                        
                        
                            Nat. Genet.36:40-45(2004)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ILE-281 
                    
                    
                    tissue :
                    
Heart .  
             
         
            
        
            
                3.
                
                    
                        
                            "The DNA sequence, annotation and analysis of human chromosome 3." 
                        
                        
                            Muzny D.M. 
                        ,
                            
Scherer S.E. 
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Kaul R. 
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Wang J. 
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Yu J. 
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Chen R. 
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Ding Y. 
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Gill R. 
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Harris R.A. 
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Hawes A.C. 
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Hernandez J. 
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Hodgson A.V. 
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Hume J. 
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                            Jackson A. 
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                        ,
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                        ,
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                        ,
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                            Yuan Y. 
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                            Zhang Z. 
                        ,
                            Adams C.Q. 
                        ,
                            Ansari-Lari M.A. 
                        ,
                            Ayele M. 
                        ,
                            Brown M.J. 
                        ,
                            Chen G. 
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                            Chen Z. 
                        ,
                            Clendenning J. 
                        ,
                            Clerc-Blankenburg K.P. 
                        ,
                            Chen R. 
                        ,
                            Chen Z. 
                        ,
                            Davis C. 
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                            Delgado O. 
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                            Dinh H.H. 
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                            Dong W. 
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                            Ernst S. 
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                            Fu G. 
                        ,
                            Gonzalez-Garay M.L. 
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                            Garcia D.K. 
                        ,
                            Gillett W. 
                        ,
                            Gu J. 
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                            Hao B. 
                        ,
                            Haugen E. 
                        ,
                            Havlak P. 
                        ,
                            He X. 
                        ,
                            Hennig S. 
                        ,
                            Hu S. 
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                            Huang W. 
                        ,
                            Jackson L.R. 
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                            Jacob L.S. 
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                            Kelly S.H. 
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                            Kube M. 
                        ,
                            Levy R. 
                        ,
                            Li Z. 
                        ,
                            Liu B. 
                        ,
                            Liu J. 
                        ,
                            Liu W. 
                        ,
                            Lu J. 
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                            Maheshwari M. 
                        ,
                            Nguyen B.-V. 
                        ,
                            Okwuonu G.O. 
                        ,
                            Palmeiri A. 
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                            Pasternak S. 
                        ,
                            Perez L.M. 
                        ,
                            Phelps K.A. 
                        ,
                            Plopper F.J. 
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                            Qiang B. 
                        ,
                            Raymond C. 
                        ,
                            Rodriguez R. 
                        ,
                            Saenphimmachak C. 
                        ,
                            Santibanez J. 
                        ,
                            Shen H. 
                        ,
                            Shen Y. 
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                            Subramanian S. 
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                            Tabor P.E. 
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                            Verduzco D. 
                        ,
                            Waldron L. 
                        ,
                            Wang J. 
                        ,
                            Wang J. 
                        ,
                            Wang Q. 
                        ,
                            Williams G.A. 
                        ,
                            Wong G.K.-S. 
                        ,
                            Yao Z. 
                        ,
                            Zhang J. 
                        ,
                            Zhang X. 
                        ,
                            Zhao G. 
                        ,
                            Zhou J. 
                        ,
                            Zhou Y. 
                        ,
                            Nelson D. 
                        ,
                            Lehrach H. 
                        ,
                            Reinhardt R. 
                        ,
                            Naylor S.L. 
                        ,
                            Yang H. 
                        ,
                            Olson M. 
                        ,
                            Weinstock G. 
                        ,
                            Gibbs R.A. 
                        
                             
                              more...   
                             
                        
                        
                        
                            Nature440:1194-1198(2006)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                4.
                
                    
                        
                        
                            Mural R.J. 
                        ,
                            
Istrail S. 
                        ,
                            
Sutton G.G. 
                        ,
                            
Florea L. 
                        ,
                            
Halpern A.L. 
                        ,
                            
Mobarry C.M. 
                        ,
                            
Lippert R. 
                        ,
                            
Walenz B. 
                        ,
                            
Shatkay H. 
                        ,
                            
Dew I. 
                        ,
                            
Miller J.R. 
                        ,
                            
Flanigan M.J. 
                        ,
                            
Edwards N.J. 
                        ,
                            
Bolanos R. 
                        ,
                            
Fasulo D. 
                        ,
                            
Halldorsson B.V. 
                        ,
                            
Hannenhalli S. 
                        ,
                            
Turner R. 
                        ,
                        
                        
                            Yooseph S. 
                        ,
                            Lu F. 
                        ,
                            Nusskern D.R. 
                        ,
                            Shue B.C. 
                        ,
                            Zheng X.H. 
                        ,
                            Zhong F. 
                        ,
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                        ,
                            Huson D.H. 
                        ,
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                        ,
                            Mouchard L. 
                        ,
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                        ,
                            Remington K.A. 
                        ,
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                        ,
                            Waterman M.S. 
                        ,
                            Eichler E.E. 
                        ,
                            Adams M.D. 
                        ,
                            Hunkapiller M.W. 
                        ,
                            Myers E.W. 
                        ,
                            Venter J.C. 
                        
                             
                              more...   
                             
                        
                        
                            Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
                        
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ILE-281 
                    
                    
                 
             
         
            
        
            
                5.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] 
                    
                    
                    tissue :
                    
Colon .  
             
         
            
        
            
                6.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for PARTIAL PROTEIN SEQUENCE;CHARACTERIZATION 
                    
                    
                    tissue :
                    
Liver .  
             
         
            
        
            
                7.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for FUNCTION 
                    
                    
                 
             
         
            
        
            
                8.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;BIOPHYSICOCHEMICAL PROPERTIES 
                    
                    
                 
             
         
            
        
            
                9.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-78 AND ASN-282 
                    
                    
                    tissue :
                    
Liver .  
             
         
            
        
            
                10.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for BIOPHYSICOCHEMICAL PROPERTIES;FUNCTION;TISSUE SPECIFICITY 
                    
                    
                 
             
         
            
        
            
                11.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;BIOPHYSICOCHEMICAL PROPERTIES;VARIANTS ILE-281 AND GLN-399 EXT;CHARACTERIZATION OF VARIANTS ILE-281 AND GLN-399 EXT 
                    
                    
                 
             
         
            
        
            
                12.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for BIOPHYSICOCHEMICAL PROPERTIES;GLYCOSYLATION AT ASN-78 AND ASN-282;MUTAGENESIS OF ASN-78 AND ASN-282 
                    
                    
                 
             
         
            
        
            
                13.
                
                    
                        
                            "Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production." 
                        
                        
                            Nourbakhsh M. 
                        ,
                            
Douglas D.N. 
                        ,
                            
Pu C.H. 
                        ,
                            
Lewis J.T. 
                        ,
                            
Kawahara T. 
                        ,
                            
Lisboa L.F. 
                        ,
                            
Wei E. 
                        ,
                            
Asthana S. 
                        ,
                            
Quiroga A.D. 
                        ,
                            
Law L.M. 
                        ,
                            
Chen C. 
                        ,
                            
Addison W.R. 
                        ,
                            
Nelson R. 
                        ,
                            
Houghton M. 
                        ,
                            
Lehner R. 
                        ,
                            
Kneteman N.M. 
                        
                        
                        
                        
                            J. Hepatol.59:336-343(2013)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for FUNCTION;INDUCTION 
                    
                    
                 
             
         
            
        
            
                14.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for VARIANT ILE-281