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Index > Protein center > AADAC(Gene name) > Human
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  • AADAC (Gene name),
  • Arylacetamide deacetylase (Protein name ),  AAAD_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    AADAC(DAC);
    Protein name:
    Arylacetamide deacetylase;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass type II membrane protein Microsome membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    399
    Sequence:
    50:
    MGRKSLYLLI | VGILIAYYIY | TPLPDNVEEP | WRMMWINAHL | KTIQNLATFV | 
    100:
    ELLGLHHFMD | SFKVVGSFDE | VPPTSDENVT | VTETKFNNIL | VRVYVPKRKS | 
    150:
    EALRRGLFYI | HGGGWCVGSA | ALSGYDLLSR | WTADRLDAVV | VSTNYRLAPK | 
    200:
    YHFPIQFEDV | YNALRWFLRK | KVLAKYGVNP | ERIGISGDSA | GGNLAAAVTQ | 
    250:
    QLLDDPDVKI | KLKIQSLIYP | ALQPLDVDLP | SYQENSNFLF | LSKSLMVRFW | 
    300:
    SEYFTTDRSL | EKAMLSRQHV | PVESSHLFKF | VNWSSLLPER | FIKGHVYNNP | 
    350:
    NYGSSELAKK | YPGFLDVRAA | PLLADDNKLR | GLPLTYVITC | QYDLLRDDGL | 
    399:
    MYVTRLRNTG | VQVTHNHVED | GFHGAFSFLG | LKISHRLINQ | YIEWLKENL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    UniGene:
    Pfam:
    SMR:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Arylacetamide deacetylase
    ELISA Kit for Human Arylacetamide deacetylase
    ELISA Kit for Human Arylacetamide deacetylase
    ELISA Kit for Human Arylacetamide deacetylase
    ELISA Kit for Human Arylacetamide deacetylase
    CLIA Kit for Human Arylacetamide deacetylase
    CLIA Kit for Human Arylacetamide deacetylase
    CLIA Kit for Human Arylacetamide deacetylase
    CLIA Kit for Human Arylacetamide deacetylase
    CLIA Kit for Human Arylacetamide deacetylase
    Polyclonal Antibody for Human Arylacetamide deacetylase
    Polyclonal Antibody for Human Arylacetamide deacetylase
    Polyclonal Antibody for Human Arylacetamide deacetylase
    Polyclonal Antibody for Human Arylacetamide deacetylase
    Polyclonal Antibody for Human Arylacetamide deacetylase
    Monoclonal Antibody for Human Arylacetamide deacetylase
    Monoclonal Antibody for Human Arylacetamide deacetylase
    Monoclonal Antibody for Human Arylacetamide deacetylase
    Monoclonal Antibody for Human Arylacetamide deacetylase
    Monoclonal Antibody for Human Arylacetamide deacetylase
    Protein for Human Arylacetamide deacetylase
    Protein for Human Arylacetamide deacetylase
    Protein for Human Arylacetamide deacetylase
    Protein for Human Arylacetamide deacetylase
    Protein for Human Arylacetamide deacetylase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase."
      Probst M.R. , Beer M. , Beer D. , Jenoe P. , Meyer U.A. , Gasser R.
      J. Biol. Chem.269:21650-21656(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;VARIANT ILE-281
      tissue: Liver.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ILE-281
      tissue: Heart.
    3. 3.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ILE-281
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Colon.
    6. 6.
      "Purification and characterization of a human liver arylacetamide deacetylase."
      Probst M.R. , Jenoe P. , Meyer U.A.
      Biochem. Biophys. Res. Commun.177:453-459(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;CHARACTERIZATION
      tissue: Liver.
    7. 7.
      "Human carboxylesterases and their role in xenobiotic and endobiotic metabolism."
      Ross M.K. , Crow J.A.
      J. Biochem. Mol. Toxicol.21:187-196(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis."
      Watanabe A. , Fukami T. , Nakajima M. , Takamiya M. , Aoki Y. , Yokoi T.
      Drug Metab. Dispos.37:1513-1520(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;BIOPHYSICOCHEMICAL PROPERTIES
    9. 9.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-78 AND ASN-282
      tissue: Liver.
    10. 10.
      "Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse."
      Kobayashi Y. , Fukami T. , Nakajima A. , Watanabe A. , Nakajima M. , Yokoi T.
      Drug Metab. Dispos.40:671-679(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES;FUNCTION;TISSUE SPECIFICITY
    11. 11.
      "A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity."
      Shimizu M. , Fukami T. , Kobayashi Y. , Takamiya M. , Aoki Y. , Nakajima M. , Yokoi T.
      Drug Metab. Dispos.40:1183-1190(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;BIOPHYSICOCHEMICAL PROPERTIES;VARIANTS ILE-281 AND GLN-399 EXT;CHARACTERIZATION OF VARIANTS ILE-281 AND GLN-399 EXT
    12. 12.
      "N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity."
      Muta K. , Fukami T. , Nakajima M. , Yokoi T.
      Biochem. Pharmacol.87:352-359(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES;GLYCOSYLATION AT ASN-78 AND ASN-282;MUTAGENESIS OF ASN-78 AND ASN-282
    13. 13.
      "Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production."
      Nourbakhsh M. , Douglas D.N. , Pu C.H. , Lewis J.T. , Kawahara T. , Lisboa L.F. , Wei E. , Asthana S. , Quiroga A.D. , Law L.M. , Chen C. , Addison W.R. , Nelson R. , Houghton M. , Lehner R. , Kneteman N.M.
      J. Hepatol.59:336-343(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    14. 14.
      "Catalog of 680 variations among eight cytochrome p450 (CYP) genes, nine esterase genes, and two other genes in the Japanese population."
      Saito S. , Iida A. , Sekine A. , Kawauchi S. , Higuchi S. , Ogawa C. , Nakamura Y.
      J. Hum. Genet.48:249-270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ILE-281
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