Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > SERPINA3(Gene name) > Human
  • Add your favorite
  • SERPINA3 (Gene name),
  • Alpha-1-antichymotrypsin (Protein name ),  AACT_HUMAN from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Feedback
  • Gene name:
    SERPINA3(GIG24;GIG25;AACT);
    Protein name:
    Alpha-1-antichymotrypsin(ACT);
    Alternative:
    Cell growth-inhibiting gene 24/25 protein;Serpin A3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with DNAJC1.
    Function:
    Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    423
    Sequence:
    50:
    MERMLPLLAL | GLLAAGFCPA | VLCHPNSPLD | EENLTQENQD | RGTHVDLGLA | 
    100:
    SANVDFAFSL | YKQLVLKAPD | KNVIFSPLSI | STALAFLSLG | AHNTTLTEIL | 
    150:
    KGLKFNLTET | SEAEIHQSFQ | HLLRTLNQSS | DELQLSMGNA | MFVKEQLSLL | 
    200:
    DRFTEDAKRL | YGSEAFATDF | QDSAAAKKLI | NDYVKNGTRG | KITDLIKDLD | 
    250:
    SQTMMVLVNY | IFFKAKWEMP | FDPQDTHQSR | FYLSKKKWVM | VPMMSLHHLT | 
    300:
    IPYFRDEELS | CTVVELKYTG | NASALFILPD | QDKMEEVEAM | LLPETLKRWR | 
    350:
    DSLEFREIGE | LYLPKFSISR | DYNLNDILLQ | LGIEEAFTSK | ADLSGITGAR | 
    400:
    NLAVSQVVHK | AVLDVFEEGT | EASAATAVKI | TLLSALVETR | TIVRFNRPFL | 
    423:
    MIIVPTDTQN | IFFMSKVTNP | KQA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    UniGene:
    MIM:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human ACT
    Cat.:
    E1015h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ACT
    Cat.:
    U1015h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human ACT
    Cat.:
    P1015Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human ACT
    Protein for Human ACT

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Characterisation of the tumour-associated carbohydrate epitope recognised by monoclonal antibody 4D3."
      Pinczower G.D. , Williams R.P.W. , Gianello R.D. , Robinson H.C. , Preston B.N. , Linnane A.W.
      Int. J. Cancer66:636-644(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 48-68 (ISOFORMS 1/2)
    2. 2.
      "Cloning, expression, purification, and biological activity of recombinant native and variant human alpha 1-antichymotrypsins."
      Rubin H. , Wang Z. , Nickbarg E.B. , McLarney S. , Naidoo N. , Schoenberger O.L. , Johnson J.L. , Cooperman B.S.
      J. Biol. Chem.265:1199-1207(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 87-129 (ISOFORMS 1/2);FUNCTION
      tissue: Liver.
    3. 3.
      "Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions."
      Hill R.E. , Shaw P.H. , Boyd P.A. , Baumann H. , Hastie N.D.
      Nature311:175-177(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 205-423
    4. 4.
      "Amino acid sequence at the reactive site of human alpha 1-antichymotrypsin."
      Morii M. , Travis J.
      J. Biol. Chem.258:12749-12752(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REACTIVE SITE
    5. 5.
      "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
      Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-93 AND ASN-106
    6. 6.
      "The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity."
      Kroczynska B. , Evangelista C.M. , Samant S.S. , Elguindi E.C. , Blond S.Y.
      J. Biol. Chem.279:11432-11443(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNAJC1
    7. 7.
      "Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus."
      Horvath A.J. , Forsyth S.L. , Coughlin P.B.
      J. Mol. Evol.59:488-497(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REGION RCL
    8. 8.
      "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
      Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
      Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-93
      tissue: Plasma.
    9. 9.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-33; ASN-93; ASN-106; ASN-127; ASN-186 AND ASN-271
      tissue: Plasma.
    10. 10.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-93; ASN-106; ASN-127 AND ASN-271
      tissue: Liver.
    11. 11.
      "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
      Halim A. , Ruetschi U. , Larson G. , Nilsson J.
      J. Proteome Res.12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;IDENTIFICATION BY MASS SPECTROMETRY
    12. 12.
      "Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7-A resolution and its comparison with other serpins."
      Baumann U. , Huber R. , Bode W. , Grosse D. , Lesjak M. , Laurell C.-B.
      J. Mol. Biol.218:595-606(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 24-423
    13. 13.
      "Arginine substitutions in the hinge region of antichymotrypsin affect serpin beta-sheet rearrangement."
      Lukacs C.M. , Zhong J.Q. , Plotnick M.I. , Rubin H. , Cooperman B.S. , Christianson D.W.
      Nat. Struct. Biol.3:888-893(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) OF 43-423 OF MUTANTS ARG-370 AND ARG-372
    14. 14.
      "Engineering an anion-binding cavity in antichymotrypsin modulates the 'spring-loaded' serpin-protease interaction."
      Lukacs C.M. , Rubin H. , Christianson D.W.
      Biochemistry37:3297-3304(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 43-423 OF MUTANTS ARG-370; ARG-372 AND ARG-374
    15. 15.
      "Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease."
      Gooptu B. , Hazes B. , Chang W.-S.W. , Dafforn T.R. , Carrell R.W. , Read R.J. , Lomas D.A.
      Proc. Natl. Acad. Sci. U.S.A.97:67-72(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS) OF 26-423
    16. 16.
      "Detection of a new mutant alpha-1-antichymotrypsin in patients with occlusive-cerebrovascular disease."
      Tsuda M. , Sei Y. , Yamamura M. , Yamamoto M. , Shinohara Y.
      FEBS Lett.304:66-68(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ISEHARA-1 VAL-401
    17. 17.
      "Mis-sense mutation of alpha 1-antichymotrypsin gene associated with chronic lung disease."
      Poller W. , Faber J.-P. , Scholz S. , Weindinger S. , Bartholome K. , Olek K. , Eriksson S.
      Lancet339:1538-1538(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BONN-1 ALA-252
    18. 18.
      "Alpha-1-antichymotrypsin gene A1252G variant (ACT Isehara-1) is associated with a lacunar type of ischemic cerebrovascular disease."
      Tachikawa H. , Tsuda M. , Onoe K. , Ueno M. , Takagi S. , Shinohara Y.
      J. Hum. Genet.46:45-47(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-401
    19. 19.
      "Sequence homology between human alpha 1-antichymotrypsin, alpha 1-antitrypsin, and antithrombin III."
      Chandra T. , Stackhouse R. , Kidd V.J. , Robson K.J.H. , Woo S.L.C.
      Biochemistry22:5055-5061(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Liver.
    20. 20.
      "A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease."
      Poller W. , Faber J.-P. , Weidinger S. , Tief K. , Scholz S. , Fischer M. , Olek K. , Kirchgesser M. , Heidtmann H.-H.
      Genomics17:740-743(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS BOCHUM-1 PRO-78 AND BONN-1 ALA-252
    21. 21.
      "Identification of a human cell growth inhibiting gene."
      Kim J.W.
      Submitted (2003-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT THR-9
    22. 22.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT THR-9
      tissue: Urinary bladder.
    23. 23.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT THR-9
      tissue: Brain.
    24. 24.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);VARIANTS THR-9 AND ARG-267
      tissue: Brain.
      tissue: Liver.
      tissue: Skin.
    25. 25.
      "Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease."
      Abraham C.R. , Selkoe D.J. , Potter H.
      Cell52:487-501(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-46;TISSUE SPECIFICITY
      tissue: Liver.
    26. 26.
      "Molecular studies define the primary structure of alpha1-antichymotrypsin (ACT) protease inhibitor in Alzheimer's disease brains. Comparison of act in hippocampus and liver."
      Hwang S.-R. , Steineckert B. , Kohn A. , Palkovits M. , Hook V.Y.H.
      J. Biol. Chem.274:1821-1827(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-423 (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Hippocampus.
    27. 27.
      Rubin H.
      Submitted (1989-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-86 AND 130-423 (ISOFORM 1)
    28. 28.
      "The microheterogeneity of desialylated alpha 1-antichymotrypsin: the occurrence of two amino-terminal isoforms, one lacking a His-Pro dipeptide."
      Lindmark B. , Hilja H. , Alan R. , Eriksson S.
      Biochim. Biophys. Acta997:90-95(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 24-34
    29. 29.
      "Interactions of alpha-1-antichymotrypsin, alpha-1-proteinase inhibitor, and alpha-2-macroglobulin with the fungal enzyme, seaprose."
      Korzus E. , Luisetti M. , Travis J.
      Biol. Chem. Hoppe-Seyler375:335-341(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-45
    30. 30.
      "Structural alterations in alpha 1-antichymotrypsin from normal and acute phase human plasma."
      Morii M. , Travis J.
      Biochem. Biophys. Res. Commun.111:438-443(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 41-60
    Product Feedback Wall
    Hot Genes
    ALCAM ACE KSR2 ASPRO C19orf80 Gdf5 Trap1a Atf2
    Top Searches
    Ubiquitin ELISA Asprosin Ubiquitin-protein ligase metalloproteinase TRAP1A Tumor necrosis vitamin d
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.cn

    Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    Twitter