SERPINA3 ELISA Kit for Human(Homo sapiens) | EIAab.comSERPINA3 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SERPINA3(Gene name) > Human

SERPINA3 (Gene name),

Alpha-1-antichymotrypsin (Protein name ), AACT_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

SERPINA3(GIG24;GIG25;AACT);

Protein name:

Alpha-1-antichymotrypsin(ACT);

Alternative:

Serpin A3;Cell growth-inhibiting gene 24/25 protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with DNAJC1.

Function:

Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

423

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

423:

MIIVPTDTQN | IFFMSKVTNP | KQA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.534293

String:

P01011

SMR:

P01011

KEGG:

hsa:12

Pfam:

PF00079

MIM:

107280

Uniprot:

P01011

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ELISA Kit for Human ACT

Cat.:

E1015h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human ACT

Cat.:

U1015h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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Polyclonal Antibody for Human ACT

Cat.:

P1015Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human ACT

Protein for Human ACT

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Characterisation of the tumour-associated carbohydrate epitope recognised by monoclonal antibody 4D3."
Pinczower G.D. , Williams R.P.W. , Gianello R.D. , Robinson H.C. , Preston B.N. , Linnane A.W.
Int. J. Cancer66:636-644(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 48-68 (ISOFORMS 1/2)
2.

"Cloning, expression, purification, and biological activity of recombinant native and variant human alpha 1-antichymotrypsins."
Rubin H. , Wang Z. , Nickbarg E.B. , McLarney S. , Naidoo N. , Schoenberger O.L. , Johnson J.L. , Cooperman B.S.
J. Biol. Chem.265:1199-1207(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 87-129 (ISOFORMS 1/2);FUNCTION
tissue: Liver.
3.

"Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions."
Hill R.E. , Shaw P.H. , Boyd P.A. , Baumann H. , Hastie N.D.
Nature311:175-177(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 205-423
4.

"Amino acid sequence at the reactive site of human alpha 1-antichymotrypsin."
Morii M. , Travis J.
J. Biol. Chem.258:12749-12752(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REACTIVE SITE
5.

"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-93 AND ASN-106
6.

"The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity."
Kroczynska B. , Evangelista C.M. , Samant S.S. , Elguindi E.C. , Blond S.Y.
J. Biol. Chem.279:11432-11443(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNAJC1
7.

"Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus."
Horvath A.J. , Forsyth S.L. , Coughlin P.B.
J. Mol. Evol.59:488-497(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REGION RCL
8.

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-93
tissue: Plasma.
9.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-33; ASN-93; ASN-106; ASN-127; ASN-186 AND ASN-271
tissue: Plasma.
10.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-93; ASN-106; ASN-127 AND ASN-271
tissue: Liver.
11.

"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
Halim A. , Ruetschi U. , Larson G. , Nilsson J.
J. Proteome Res.12:573-584(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;IDENTIFICATION BY MASS SPECTROMETRY
12.

"Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7-A resolution and its comparison with other serpins."
Baumann U. , Huber R. , Bode W. , Grosse D. , Lesjak M. , Laurell C.-B.
J. Mol. Biol.218:595-606(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 24-423
13.

"Arginine substitutions in the hinge region of antichymotrypsin affect serpin beta-sheet rearrangement."
Lukacs C.M. , Zhong J.Q. , Plotnick M.I. , Rubin H. , Cooperman B.S. , Christianson D.W.
Nat. Struct. Biol.3:888-893(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) OF 43-423 OF MUTANTS ARG-370 AND ARG-372
14.

"Engineering an anion-binding cavity in antichymotrypsin modulates the 'spring-loaded' serpin-protease interaction."
Lukacs C.M. , Rubin H. , Christianson D.W.
Biochemistry37:3297-3304(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 43-423 OF MUTANTS ARG-370; ARG-372 AND ARG-374
15.

"Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease."
Gooptu B. , Hazes B. , Chang W.-S.W. , Dafforn T.R. , Carrell R.W. , Read R.J. , Lomas D.A.
Proc. Natl. Acad. Sci. U.S.A.97:67-72(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS) OF 26-423
16.

"Detection of a new mutant alpha-1-antichymotrypsin in patients with occlusive-cerebrovascular disease."
Tsuda M. , Sei Y. , Yamamura M. , Yamamoto M. , Shinohara Y.
FEBS Lett.304:66-68(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ISEHARA-1 VAL-401
17.

"Mis-sense mutation of alpha 1-antichymotrypsin gene associated with chronic lung disease."
Poller W. , Faber J.-P. , Scholz S. , Weindinger S. , Bartholome K. , Olek K. , Eriksson S.
Lancet339:1538-1538(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BONN-1 ALA-252
18.

"Alpha-1-antichymotrypsin gene A1252G variant (ACT Isehara-1) is associated with a lacunar type of ischemic cerebrovascular disease."
Tachikawa H. , Tsuda M. , Onoe K. , Ueno M. , Takagi S. , Shinohara Y.
J. Hum. Genet.46:45-47(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-401
19.

"Sequence homology between human alpha 1-antichymotrypsin, alpha 1-antitrypsin, and antithrombin III."
Chandra T. , Stackhouse R. , Kidd V.J. , Robson K.J.H. , Woo S.L.C.
Biochemistry22:5055-5061(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
20.

"A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease."
Poller W. , Faber J.-P. , Weidinger S. , Tief K. , Scholz S. , Fischer M. , Olek K. , Kirchgesser M. , Heidtmann H.-H.
Genomics17:740-743(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS BOCHUM-1 PRO-78 AND BONN-1 ALA-252
21.

"Identification of a human cell growth inhibiting gene."
Kim J.W.
Submitted (2003-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT THR-9
22.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT THR-9
tissue: Urinary bladder.
23.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT THR-9
tissue: Brain.
24.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);VARIANTS THR-9 AND ARG-267
tissue: Brain.
tissue: Liver.
tissue: Skin.
25.

"Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease."
Abraham C.R. , Selkoe D.J. , Potter H.
Cell52:487-501(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-46;TISSUE SPECIFICITY
tissue: Liver.
26.

"Molecular studies define the primary structure of alpha1-antichymotrypsin (ACT) protease inhibitor in Alzheimer's disease brains. Comparison of act in hippocampus and liver."
Hwang S.-R. , Steineckert B. , Kohn A. , Palkovits M. , Hook V.Y.H.
J. Biol. Chem.274:1821-1827(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-423 (ISOFORM 1);TISSUE SPECIFICITY
tissue: Hippocampus.
27.

Rubin H.
Submitted (1989-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-86 AND 130-423 (ISOFORM 1)
28.

"The microheterogeneity of desialylated alpha 1-antichymotrypsin: the occurrence of two amino-terminal isoforms, one lacking a His-Pro dipeptide."
Lindmark B. , Hilja H. , Alan R. , Eriksson S.
Biochim. Biophys. Acta997:90-95(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 24-34
29.

"Interactions of alpha-1-antichymotrypsin, alpha-1-proteinase inhibitor, and alpha-2-macroglobulin with the fungal enzyme, seaprose."
Korzus E. , Luisetti M. , Travis J.
Biol. Chem. Hoppe-Seyler375:335-341(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-45
30.

"Structural alterations in alpha 1-antichymotrypsin from normal and acute phase human plasma."
Morii M. , Travis J.
Biochem. Biophys. Res. Commun.111:438-443(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 41-60

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