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Index > Protein center > ABCA7(Gene name) > Human
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  • ABCA7 (Gene name),
  • ATP-binding cassette sub-family A member 7 (Protein name ),  ABCA7_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ABCA7;
    Protein name:
    ATP-binding cassette sub-family A member 7;
    Alternative:
    Macrophage ABC transporter;ABCA-SSN;Autoantigen SS-N;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Golgi apparatus membrane Multi-pass membrane protein Endosome membrane Multi-pass membrane protein Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney. Isoform 2 may localize to the endoplasmic reticulum.
    Protein Attributes:
    Sequence length:
    2146
    Sequence:
    50:
    MAFWTQLMLL | LWKNFMYRRR | QPVQLLVELL | WPLFLFFILV | AVRHSHPPLE | 
    100:
    HHECHFPNKP | LPSAGTVPWL | QGLICNVNNT | CFPQLTPGEE | PGRLSNFNDS | 
    150:
    LVSRLLADAR | TVLGGASAHR | TLAGLGKLIA | TLRAARSTAQ | PQPTKQSPLE | 
    200:
    PPMLDVAELL | TSLLRTESLG | LALGQAQEPL | HSLLEAAEDL | AQELLALRSL | 
    250:
    VELRALLQRP | RGTSGPLELL | SEALCSVRGP | SSTVGPSLNW | YEASDLMELV | 
    300:
    GQEPESALPD | SSLSPACSEL | IGALDSHPLS | RLLWRRLKPL | ILGKLLFAPD | 
    350:
    TPFTRKLMAQ | VNRTFEELTL | LRDVREVWEM | LGPRIFTFMN | DSSNVAMLQR | 
    400:
    LLQMQDEGRR | QPRPGGRDHM | EALRSFLDPG | SGGYSWQDAH | ADVGHLVGTL | 
    450:
    GRVTECLSLD | KLEAAPSEAA | LVSRALQLLA | EHRFWAGVVF | LGPEDSSDPT | 
    500:
    EHPTPDLGPG | HVRIKIRMDI | DVVTRTNKIR | DRFWDPGPAA | DPLTDLRYVW | 
    550:
    GGFVYLQDLV | ERAAVRVLSG | ANPRAGLYLQ | QMPYPCYVDD | VFLRVLSRSL | 
    600:
    PLFLTLAWIY | SVTLTVKAVV | REKETRLRDT | MRAMGLSRAV | LWLGWFLSCL | 
    650:
    GPFLLSAALL | VLVLKLGDIL | PYSHPGVVFL | FLAAFAVATV | TQSFLLSAFF | 
    700:
    SRANLAAACG | GLAYFSLYLP | YVLCVAWRDR | LPAGGRVAAS | LLSPVAFGFG | 
    750:
    CESLALLEEQ | GEGAQWHNVG | TRPTADVFSL | AQVSGLLLLD | AALYGLATWY | 
    800:
    LEAVCPGQYG | IPEPWNFPFR | RSYWCGPRPP | KSPAPCPTPL | DPKVLVEEAP | 
    850:
    PGLSPGVSVR | SLEKRFPGSP | QPALRGLSLD | FYQGHITAFL | GHNGAGKTTT | 
    900:
    LSILSGLFPP | SGGSAFILGH | DVRSSMAAIR | PHLGVCPQYN | VLFDMLTVDE | 
    950:
    HVWFYGRLKG | LSAAVVGPEQ | DRLLQDVGLV | SKQSVQTRHL | SGGMQRKLSV | 
    1000:
    AIAFVGGSQV | VILDEPTAGV | DPASRRGIWE | LLLKYREGRT | LILSTHHLDE | 
    1050:
    AELLGDRVAV | VAGGRLCCCG | SPLFLRRHLG | SGYYLTLVKA | RLPLTTNEKA | 
    1100:
    DTDMEGSVDT | RQEKKNGSQG | SRVGTPQLLA | LVQHWVPGAR | LVEELPHELV | 
    1150:
    LVLPYTGAHD | GSFATLFREL | DTRLAELRLT | GYGISDTSLE | EIFLKVVEEC | 
    1200:
    AADTDMEDGS | CGQHLCTGIA | GLDVTLRLKM | PPQETALENG | EPAGSAPETD | 
    1250:
    QGSGPDAVGR | VQGWALTRQQ | LQALLLKRFL | LARRSRRGLF | AQIVLPALFV | 
    1300:
    GLALVFSLIV | PPFGHYPALR | LSPTMYGAQV | SFFSEDAPGD | PGRARLLEAL | 
    1350:
    LQEAGLEEPP | VQHSSHRFSA | PEVPAEVAKV | LASGNWTPES | PSPACQCSRP | 
    1400:
    GARRLLPDCP | AAAGGPPPPQ | AVTGSGEVVQ | NLTGRNLSDF | LVKTYPRLVR | 
    1450:
    QGLKTKKWVN | EVRYGGFSLG | GRDPGLPSGQ | ELGRSVEELW | ALLSPLPGGA | 
    1500:
    LDRVLKNLTA | WAHSLDAQDS | LKIWFNNKGW | HSMVAFVNRA | SNAILRAHLP | 
    1550:
    PGPARHAHSI | TTLNHPLNLT | KEQLSEGALM | ASSVDVLVSI | CVVFAMSFVP | 
    1600:
    ASFTLVLIEE | RVTRAKHLQL | MGGLSPTLYW | LGNFLWDMCN | YLVPACIVVL | 
    1650:
    IFLAFQQRAY | VAPANLPALL | LLLLLYGWSI | TPLMYPASFF | FSVPSTAYVV | 
    1700:
    LTCINLFIGI | NGSMATFVLE | LFSDQKLQEV | SRILKQVFLI | FPHFCLGRGL | 
    1750:
    IDMVRNQAMA | DAFERLGDRQ | FQSPLRWEVV | GKNLLAMVIQ | GPLFLLFTLL | 
    1800:
    LQHRSQLLPQ | PRVRSLPLLG | EEDEDVARER | ERVVQGATQG | DVLVLRNLTK | 
    1850:
    VYRGQRMPAV | DRLCLGIPPG | ECFGLLGVNG | AGKTSTFRMV | TGDTLASRGE | 
    1900:
    AVLAGHSVAR | EPSAAHLSMG | YCPQSDAIFE | LLTGREHLEL | LARLRGVPEA | 
    1950:
    QVAQTAGSGL | ARLGLSWYAD | RPAGTYSGGN | KRKLATALAL | VGDPAVVFLD | 
    2000:
    EPTTGMDPSA | RRFLWNSLLA | VVREGRSVML | TSHSMEECEA | LCSRLAIMVN | 
    2050:
    GRFRCLGSPQ | HLKGRFAAGH | TLTLRVPAAR | SQPAAAFVAA | EFPGAELREA | 
    2100:
    HGGRLRFQLP | PGGRCALARV | FGELAVHGAE | HGVEDFSVSQ | TMLEEVFLYF | 
    2146:
    SKDQGKDEDT | EEQKEAGVGV | DPAPGLQHPK | RVSQFLDDPS | TAETVL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    SMR:
    MIM:
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human ATP-binding cassette sub-family A member 7
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    E15004h
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    ELISA Kit for Human ATP-binding cassette sub-family A member 7
    Cat.:
    E15004m
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    Packing:
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    ELISA Kit for Human ATP-binding cassette sub-family A member 7
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    CLIA Kit for Human ATP-binding cassette sub-family A member 7
    MSDS:
    Please sign in first.
    CLIA Kit for Human ATP-binding cassette sub-family A member 7
    Cat.:
    U15004h
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human ATP-binding cassette sub-family A member 7
    Cat.:
    U15004m
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human ATP-binding cassette sub-family A member 7
    Polyclonal Antibody for Human ATP-binding cassette sub-family A member 7
    Polyclonal Antibody for Human ATP-binding cassette sub-family A member 7
    Monoclonal Antibody for Human ATP-binding cassette sub-family A member 7
    Monoclonal Antibody for Human ATP-binding cassette sub-family A member 7
    Monoclonal Antibody for Human ATP-binding cassette sub-family A member 7
    Protein for Human ATP-binding cassette sub-family A member 7
    Protein for Human ATP-binding cassette sub-family A member 7
    Protein for Human ATP-binding cassette sub-family A member 7

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7)."
      Kaminski W.E. , Orso E. , Diederich W. , Klucken J. , Drobnik W. , Schmitz G.
      Biochem. Biophys. Res. Commun.273:532-538(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS GLN-1349; ALA-1527 AND SER-2045;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INDUCTION
      tissue: Macrophage.
    2. 2.
      "Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene."
      Kaminski W.E. , Piehler A. , Schmitz G.
      Biochem. Biophys. Res. Commun.278:782-789(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ALA-1527
    3. 3.
      "Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjogren's Syndrome."
      Tanaka A.R. , Ikeda Y. , Abe-Dohmae S. , Arakawa R. , Sadanami K. , Kidera A. , Nakagawa S. , Nagase T. , Aoki R. , Kioka N. , Amachi T. , Yokoyama S. , Ueda K.
      Biochem. Biophys. Res. Commun.283:1019-1025(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANTS GLN-1349; ALA-1527 AND SER-2045
      tissue: Thymus.
    4. 4.
      "Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter."
      Broccardo C. , Osorio J. , Luciani M.-F. , Schriml L.M. , Prades C. , Shulenin S. , Arnould I. , Naudin L. , Lafargue C. , Rosier M. , Jordan B. , Mattei M.-G. , Dean M. , Denefle P. , Chimini G.
      Cytogenet. Cell Genet.92:264-270(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS GLY-188; ALA-1527 AND SER-2045;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
      tissue: Spleen.
    5. 5.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "Isolation of autoantigen cDNAs by lambda phage surface display."
      Niwa M. , Maruyama M. , Fujimoto T. , Dohi K. , Maruyama I.N.
      Submitted (1999-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 195-352 (ISOFORMS 1/2)
      tissue: Cervix carcinoma.
    7. 7.
      "Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release."
      Ikeda Y. , Abe-Dohmae S. , Munehira Y. , Aoki R. , Kawamoto S. , Furuya A. , Shitara K. , Amachi T. , Kioka N. , Matsuo M. , Yokoyama S. , Ueda K.
      Biochem. Biophys. Res. Commun.311:313-318(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    8. 8.
      "ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux."
      Wang N. , Lan D. , Gerbod-Giannone M. , Linsel-Nitschke P. , Jehle A.W. , Chen W. , Martinez L.O. , Tall A.R.
      J. Biol. Chem.278:42906-42912(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    9. 9.
      "Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization."
      Kielar D. , Kaminski W.E. , Liebisch G. , Piehler A. , Wenzel J.J. , Moehle C. , Heimerl S. , Langmann T. , Friedrich S.O. , Boettcher A. , Barlage S. , Drobnik W. , Schmitz G.
      J. Invest. Dermatol.121:465-474(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    10. 10.
      "Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein."
      Abe-Dohmae S. , Ikeda Y. , Matsuo M. , Hayashi M. , Okuhira K. , Ueda K. , Yokoyama S.
      J. Biol. Chem.279:604-611(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    11. 11.
      "Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8."
      Iida A. , Saito S. , Sekine A. , Mishima C. , Kitamura Y. , Kondo K. , Harigae S. , Osawa S. , Nakamura Y.
      J. Hum. Genet.47:285-310(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLY-188; ALA-319; ARG-395; HIS-463; THR-718; GLN-1349; ARG-1686 AND SER-2045
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