ABCB5 ELISA Kit for Human(Homo sapiens) | EIAab.comABCB5 ELISA Kit for Human(Homo sapiens)

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ABCB5 (Gene name),

ATP-binding cassette sub-family B member 5 (Protein name ), ABCB5_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ABCB5;

Protein name:

ATP-binding cassette sub-family B member 5;

Alternative:

P-glycoprotein ABCB5;ABCB5 P-gp;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas.

Subcellular Location:

Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

812

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

812:

IYFKLVNAQS | VQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q2M3G0

UniGene:

Hs.404102

Pfam:

PF00664

KEGG:

hsa:340273

SMR:

Q2M3G0

MIM:

611785

Uniprot:

Q2M3G0

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ELISA Kit for Human ATP-binding cassette sub-family B member 5

Cat.:

E10410h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human ATP-binding cassette sub-family B member 5

Cat.:

U10410h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human ATP-binding cassette sub-family B member 5

Cat.:

P10410Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human ATP-binding cassette sub-family B member 5

Protein for Human ATP-binding cassette sub-family B member 5

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter."
Frank N.Y. , Pendse S.S. , Lapchak P.H. , Margaryan A. , Shlain D. , Doeing C. , Sayegh M.H. , Frank M.H.
J. Biol. Chem.278:47156-47165(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;VARIANT LYS-970
tissue: Melanocyte.
tissue: Melanoma.
2.

"Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes."
Chen K.G. , Szakacs G. , Annereau J.-P. , Rouzaud F. , Liang X.-J. , Valencia J.C. , Nagineni C.N. , Hooks J.J. , Hearing V.J. , Gottesman M.M.
Pigment Cell Res.18:102-112(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANTS GLU-560 AND LYS-970;TISSUE SPECIFICITY
tissue: Melanoma.
3.

"ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients."
Wilson B.J. , Schatton T. , Zhan Q. , Gasser M. , Ma J. , Saab K.R. , Schanche R. , Waaga-Gasser A.M. , Gold J.S. , Huang Q. , Murphy G.F. , Frank M.H. , Frank N.Y.
Cancer Res.71:5307-5316(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Colon adenocarcinoma.
4.

"Expression of human ABCB5 confers resistance to taxanes and anthracyclines."
Kawanobe T. , Kogure S. , Nakamura S. , Sato M. , Katayama K. , Mitsuhashi J. , Noguchi K. , Sugimoto Y.
Biochem. Biophys. Res. Commun.418:736-741(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);FUNCTION;VARIANT LYS-970
tissue: Prostate.
tissue: Testis.
5.

Meij I.C. , van Aubel R. , Tammur J. , Dean M. , Russel F.G. , Allikmets R. , Cremers F.P.M.
Submitted (2003-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);VARIANT LYS-970
6.

"The DNA sequence of human chromosome 7."
Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"Human chromosome 7: DNA sequence and biology."
Scherer S.W. , Cheung J. , MacDonald J.R. , Osborne L.R. , Nakabayashi K. , Herbrick J.-A. , Carson A.R. , Parker-Katiraee L. , Skaug J. , Khaja R. , Zhang J. , Hudek A.K. , Li M. , Haddad M. , Duggan G.E. , Fernandez B.A. , Kanematsu E. , Gentles S. , more...
Science300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT LYS-970
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
tissue: Melanoma.
10.

"Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance."
Huang Y. , Anderle P. , Bussey K.J. , Barbacioru C. , Shankavaram U. , Dai Z. , Reinhold W.C. , Papp A. , Weinstein J.N. , Sadee W.
Cancer Res.64:4294-4301(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma."
Frank N.Y. , Margaryan A. , Huang Y. , Schatton T. , Waaga-Gasser A.M. , Gasser M. , Sayegh M.H. , Sadee W. , Frank M.H.
Cancer Res.65:4320-4333(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"ABCB5 expression and cancer stem cell hypothesis in oral squamous cell carcinoma."
Grimm M. , Krimmel M. , Polligkeit J. , Alexander D. , Munz A. , Kluba S. , Keutel C. , Hoffmann J. , Reinert S. , Hoefert S.
Eur. J. Cancer48:3186-3197(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
13.

"Expression of ABCB5 gene in hematological malignances and its significance."
Yang M. , Li W. , Fan D. , Yan Y. , Zhang X. , Zhang Y. , Xiong D.
Leuk. Lymphoma53:1211-1215(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
14.

"Melanoma chemotherapy leads to the selection of ABCB5-expressing cells."
Chartrain M. , Riond J. , Stennevin A. , Vandenberghe I. , Gomes B. , Lamant L. , Meyer N. , Gairin J.E. , Guilbaud N. , Annereau J.P.
PLoS ONE7:E36762-E36762(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
15.

"Genetically determined ABCB5 functionality correlates with pigmentation phenotype and melanoma risk."
Lin J.Y. , Zhang M. , Schatton T. , Wilson B.J. , Alloo A. , Ma J. , Qureshi A.A. , Frank N.Y. , Han J. , Frank M.H.
Biochem. Biophys. Res. Commun.436:536-542(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
16.

"ABCB5 maintains melanoma-initiating cells through a pro-inflammatory cytokine signaling circuit."
Wilson B.J. , Saab K.R. , Ma J. , Schatton T. , Putz P. , Zhan Q. , Murphy G.F. , Gasser M. , Waaga-Gasser A.M. , Frank N.Y. , Frank M.H.
Cancer Res.74:4196-4207(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
17.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-675
18.

"Core signaling pathways in human pancreatic cancers revealed by global genomic analyses."
Jones S. , Zhang X. , Parsons D.W. , Lin J.C. , Leary R.J. , Angenendt P. , Mankoo P. , Carter H. , Kamiyama H. , Jimeno A. , Hong S.M. , Fu B. , Lin M.T. , Calhoun E.S. , Kamiyama M. , Walter K. , Nikolskaya T. , Nikolsky Y. , more...
Science321:1801-1806(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-880
19.

"ABCB5 is a limbal stem cell gene required for corneal development and repair."
Ksander B.R. , Kolovou P.E. , Wilson B.J. , Saab K.R. , Guo Q. , Ma J. , McGuire S.P. , Gregory M.S. , Vincent W.J. , Perez V.L. , Cruz-Guilloty F. , Kao W.W. , Call M.K. , Tucker B.A. , Zhan Q. , Murphy G.F. , Lathrop K.L. , Alt C. , more...
Nature511:353-357(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY

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